We are analyzing https://link.springer.com/article/10.1007/s43032-020-00430-0.

Title:
Gut Microbiota in Patients with Polycystic Ovary Syndrome: a Systematic Review | Reproductive Sciences
Description:
Polycystic ovary Syndrome (PCOS) is one of the most popular diseases that cause menstrual dysfunction and infertility in women. Recently, the relationships between the gastrointestinal microbiome and metabolic disorders such as obesity, type 2 diabetes and PCOS have been discovered. However, the association between the gut microbiome and PCOS symptoms has not been well established. We systematically reviewed existing studies comparing gut microbial composition in PCOS and healthy volunteers to explore evidence for this association. A systematic search was carried out in PubMed, Embase, Cochrane Library, and Web of Science from inception to May 26, 2020, for all original cross-sectional, cohort, or case-control studies comparing the fecal microbiomes of patients with PCOS with microbiomes of healthy volunteers (controls). The primary outcomes were differences in specific gut microbes between patients with PCOS and controls. The search identified 256 citations; 10 studies were included. The total population study of these articles consists of 611 participants (including PCOS group and healthy controls group). Among the included 10 studies, nine studies compared α-diversity, and six studies demonstrated that α-diversity has a significant reduction in PCOS patients. Seven of them reported that there was a significant difference of β-diversity composition between healthy controls groups and PCOS patients. The most common bacterial alterations in PCOS patients included Bacteroidaceae, Coprococcus, Bacteroides, Prevotella, Lactobacillus, Parabacteroides, Escherichia/Shigella, and Faecalibacterium prausnitzii. No consensus has emerged from existing human studies of PCOS and gut microbiome concerning which bacterial taxa are most relevant to it. In this systematic review, we identified specific bacteria associated with microbiomes of patients with PCOS vs controls. Higher level of evidence is needed to determine whether these microbes are a product or cause of PCOS.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Health & Fitness
Non-Profit & Charity

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,603,474 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't tell how the site generates income.

Earning money isn't the goal of every website; some are designed to offer support or promote social causes. People have different reasons for creating websites. This might be one such reason. Link.springer.com might be plotting its profit, but the way they're doing it isn't detectable yet.

Keywords {🔍}

pubmed, article, google, scholar, gut, cas, syndrome, polycystic, ovary, pcos, microbiota, central, insulin, microbiome, patients, women, studies, review, resistance, endocrinol, systematic, zhang, human, clin, nature, metabolic, controls, metab, search, healthy, dysbiosis, ovarian, receptor, sex, privacy, cookies, content, research, reproductive, yang, obesity, microbial, composition, microbes, study, access, microbiol, cell, data, information,

Topics {✒️}

month download article/chapter tumor necrosis factor-alpha shuaitong li & junping hu short-chain fatty acids sequencing-based microbiome research case-control studies comparing letrozole-induced mouse model dihydrotestosterone-induced pcos rats prevent low-grade inflammation gut microbial community gut microbial diversity studies compared α-diversity full article pdf existing human studies related subjects polycystic ovary syndrome gut microbiota dysbiosis privacy choices/manage cookies prenatal androgen exposure polycystic ovarian syndrome including pcos group gut-brain axis brain-gut axis made considerable contributions gut microbiota composition gut microbiome composition article guo permutational multivariate analysis human gut microbiota polycystic ovarian morphology human colonic microbiota human gut microbiome glp-1-based therapies junping hu healthy controls group β-diversity composition characteristic gut microbiota linking gut microbiota protein-coupled receptor reporting systematic reviews understanding human health european economic area original cross-sectional molecular genetics bulk rna-seq martínez-garcía má ghrelin induces adiposity tight junction proteins meta-analysis obese pcos individuals

Questions {❓}

What is new and relevant for sequencing-based microbiome research?
Will gut microbiota help design the next generation of GLP-1-based therapies for type 2 diabetes?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Gut Microbiota in Patients with Polycystic Ovary Syndrome: a Systematic Review
         description:Polycystic ovary Syndrome (PCOS) is one of the most popular diseases that cause menstrual dysfunction and infertility in women. Recently, the relationships between the gastrointestinal microbiome and metabolic disorders such as obesity, type 2 diabetes and PCOS have been discovered. However, the association between the gut microbiome and PCOS symptoms has not been well established. We systematically reviewed existing studies comparing gut microbial composition in PCOS and healthy volunteers to explore evidence for this association. A systematic search was carried out in PubMed, Embase, Cochrane Library, and Web of Science from inception to May 26, 2020, for all original cross-sectional, cohort, or case-control studies comparing the fecal microbiomes of patients with PCOS with microbiomes of healthy volunteers (controls). The primary outcomes were differences in specific gut microbes between patients with PCOS and controls. The search identified 256 citations; 10 studies were included. The total population study of these articles consists of 611 participants (including PCOS group and healthy controls group). Among the included 10 studies, nine studies compared α-diversity, and six studies demonstrated that α-diversity has a significant reduction in PCOS patients. Seven of them reported that there was a significant difference of β-diversity composition between healthy controls groups and PCOS patients. The most common bacterial alterations in PCOS patients included Bacteroidaceae, Coprococcus, Bacteroides, Prevotella, Lactobacillus, Parabacteroides, Escherichia/Shigella, and Faecalibacterium prausnitzii. No consensus has emerged from existing human studies of PCOS and gut microbiome concerning which bacterial taxa are most relevant to it. In this systematic review, we identified specific bacteria associated with microbiomes of patients with PCOS vs controls. Higher level of evidence is needed to determine whether these microbes are a product or cause of PCOS.
         datePublished:2021-01-06T00:00:00Z
         dateModified:2021-01-06T00:00:00Z
         pageStart:69
         pageEnd:83
         sameAs:https://doi.org/10.1007/s43032-020-00430-0
         keywords:
            Microbiota
            Polycystic ovary syndrome
            Comparison
            Dysbiosis
            Systematic review
            Reproductive Medicine
            Embryology
            Obstetrics/Perinatology/Midwifery
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs43032-020-00430-0/MediaObjects/43032_2020_430_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs43032-020-00430-0/MediaObjects/43032_2020_430_Fig2_HTML.png
         isPartOf:
            name:Reproductive Sciences
            issn:
               1933-7205
               1933-7191
            volumeNumber:29
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer International Publishing
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Jingbo Guo
               affiliation:
                     name:Lanzhou University
                     address:
                        name:School of Nursing, Lanzhou University, Lanzhou, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jie Shao
               affiliation:
                     name:Lanzhou University
                     address:
                        name:School of Nursing, Lanzhou University, Lanzhou, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yuan Yang
               affiliation:
                     name:Key Laboratory for Reproductive Medicine and Embryo
                     address:
                        name:The Reproductive Medicine Special Hospital of the 1st Hospital of Lanzhou University, Key Laboratory for Reproductive Medicine and Embryo, Lanzhou, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Xiaodan Niu
               affiliation:
                     name:Lanzhou University
                     address:
                        name:School of Nursing, Lanzhou University, Lanzhou, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Juan Liao
               affiliation:
                     name:Lanzhou University
                     address:
                        name:School of Nursing, Lanzhou University, Lanzhou, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Qing Zhao
               affiliation:
                     name:Lanzhou University
                     address:
                        name:School of Nursing, Lanzhou University, Lanzhou, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Donghui Wang
               affiliation:
                     name:Lanzhou University
                     address:
                        name:School of Nursing, Lanzhou University, Lanzhou, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Shuaitong Li
               affiliation:
                     name:Lanzhou University
                     address:
                        name:School of Nursing, Lanzhou University, Lanzhou, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Junping Hu
               url:http://orcid.org/0000-0003-1412-6950
               affiliation:
                     name:Lanzhou University
                     address:
                        name:School of Nursing, Lanzhou University, Lanzhou, China
                        type:PostalAddress
                     type:Organization
                     name:Key Laboratory for Reproductive Medicine and Embryo
                     address:
                        name:The Reproductive Medicine Special Hospital of the 1st Hospital of Lanzhou University, Key Laboratory for Reproductive Medicine and Embryo, Lanzhou, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Gut Microbiota in Patients with Polycystic Ovary Syndrome: a Systematic Review
      description:Polycystic ovary Syndrome (PCOS) is one of the most popular diseases that cause menstrual dysfunction and infertility in women. Recently, the relationships between the gastrointestinal microbiome and metabolic disorders such as obesity, type 2 diabetes and PCOS have been discovered. However, the association between the gut microbiome and PCOS symptoms has not been well established. We systematically reviewed existing studies comparing gut microbial composition in PCOS and healthy volunteers to explore evidence for this association. A systematic search was carried out in PubMed, Embase, Cochrane Library, and Web of Science from inception to May 26, 2020, for all original cross-sectional, cohort, or case-control studies comparing the fecal microbiomes of patients with PCOS with microbiomes of healthy volunteers (controls). The primary outcomes were differences in specific gut microbes between patients with PCOS and controls. The search identified 256 citations; 10 studies were included. The total population study of these articles consists of 611 participants (including PCOS group and healthy controls group). Among the included 10 studies, nine studies compared α-diversity, and six studies demonstrated that α-diversity has a significant reduction in PCOS patients. Seven of them reported that there was a significant difference of β-diversity composition between healthy controls groups and PCOS patients. The most common bacterial alterations in PCOS patients included Bacteroidaceae, Coprococcus, Bacteroides, Prevotella, Lactobacillus, Parabacteroides, Escherichia/Shigella, and Faecalibacterium prausnitzii. No consensus has emerged from existing human studies of PCOS and gut microbiome concerning which bacterial taxa are most relevant to it. In this systematic review, we identified specific bacteria associated with microbiomes of patients with PCOS vs controls. Higher level of evidence is needed to determine whether these microbes are a product or cause of PCOS.
      datePublished:2021-01-06T00:00:00Z
      dateModified:2021-01-06T00:00:00Z
      pageStart:69
      pageEnd:83
      sameAs:https://doi.org/10.1007/s43032-020-00430-0
      keywords:
         Microbiota
         Polycystic ovary syndrome
         Comparison
         Dysbiosis
         Systematic review
         Reproductive Medicine
         Embryology
         Obstetrics/Perinatology/Midwifery
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs43032-020-00430-0/MediaObjects/43032_2020_430_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs43032-020-00430-0/MediaObjects/43032_2020_430_Fig2_HTML.png
      isPartOf:
         name:Reproductive Sciences
         issn:
            1933-7205
            1933-7191
         volumeNumber:29
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Jingbo Guo
            affiliation:
                  name:Lanzhou University
                  address:
                     name:School of Nursing, Lanzhou University, Lanzhou, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jie Shao
            affiliation:
                  name:Lanzhou University
                  address:
                     name:School of Nursing, Lanzhou University, Lanzhou, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yuan Yang
            affiliation:
                  name:Key Laboratory for Reproductive Medicine and Embryo
                  address:
                     name:The Reproductive Medicine Special Hospital of the 1st Hospital of Lanzhou University, Key Laboratory for Reproductive Medicine and Embryo, Lanzhou, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xiaodan Niu
            affiliation:
                  name:Lanzhou University
                  address:
                     name:School of Nursing, Lanzhou University, Lanzhou, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Juan Liao
            affiliation:
                  name:Lanzhou University
                  address:
                     name:School of Nursing, Lanzhou University, Lanzhou, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Qing Zhao
            affiliation:
                  name:Lanzhou University
                  address:
                     name:School of Nursing, Lanzhou University, Lanzhou, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Donghui Wang
            affiliation:
                  name:Lanzhou University
                  address:
                     name:School of Nursing, Lanzhou University, Lanzhou, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Shuaitong Li
            affiliation:
                  name:Lanzhou University
                  address:
                     name:School of Nursing, Lanzhou University, Lanzhou, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Junping Hu
            url:http://orcid.org/0000-0003-1412-6950
            affiliation:
                  name:Lanzhou University
                  address:
                     name:School of Nursing, Lanzhou University, Lanzhou, China
                     type:PostalAddress
                  type:Organization
                  name:Key Laboratory for Reproductive Medicine and Embryo
                  address:
                     name:The Reproductive Medicine Special Hospital of the 1st Hospital of Lanzhou University, Key Laboratory for Reproductive Medicine and Embryo, Lanzhou, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Reproductive Sciences
      issn:
         1933-7205
         1933-7191
      volumeNumber:29
Organization:
      name:Springer International Publishing
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Lanzhou University
      address:
         name:School of Nursing, Lanzhou University, Lanzhou, China
         type:PostalAddress
      name:Lanzhou University
      address:
         name:School of Nursing, Lanzhou University, Lanzhou, China
         type:PostalAddress
      name:Key Laboratory for Reproductive Medicine and Embryo
      address:
         name:The Reproductive Medicine Special Hospital of the 1st Hospital of Lanzhou University, Key Laboratory for Reproductive Medicine and Embryo, Lanzhou, China
         type:PostalAddress
      name:Lanzhou University
      address:
         name:School of Nursing, Lanzhou University, Lanzhou, China
         type:PostalAddress
      name:Lanzhou University
      address:
         name:School of Nursing, Lanzhou University, Lanzhou, China
         type:PostalAddress
      name:Lanzhou University
      address:
         name:School of Nursing, Lanzhou University, Lanzhou, China
         type:PostalAddress
      name:Lanzhou University
      address:
         name:School of Nursing, Lanzhou University, Lanzhou, China
         type:PostalAddress
      name:Lanzhou University
      address:
         name:School of Nursing, Lanzhou University, Lanzhou, China
         type:PostalAddress
      name:Lanzhou University
      address:
         name:School of Nursing, Lanzhou University, Lanzhou, China
         type:PostalAddress
      name:Key Laboratory for Reproductive Medicine and Embryo
      address:
         name:The Reproductive Medicine Special Hospital of the 1st Hospital of Lanzhou University, Key Laboratory for Reproductive Medicine and Embryo, Lanzhou, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Jingbo Guo
      affiliation:
            name:Lanzhou University
            address:
               name:School of Nursing, Lanzhou University, Lanzhou, China
               type:PostalAddress
            type:Organization
      name:Jie Shao
      affiliation:
            name:Lanzhou University
            address:
               name:School of Nursing, Lanzhou University, Lanzhou, China
               type:PostalAddress
            type:Organization
      name:Yuan Yang
      affiliation:
            name:Key Laboratory for Reproductive Medicine and Embryo
            address:
               name:The Reproductive Medicine Special Hospital of the 1st Hospital of Lanzhou University, Key Laboratory for Reproductive Medicine and Embryo, Lanzhou, China
               type:PostalAddress
            type:Organization
      name:Xiaodan Niu
      affiliation:
            name:Lanzhou University
            address:
               name:School of Nursing, Lanzhou University, Lanzhou, China
               type:PostalAddress
            type:Organization
      name:Juan Liao
      affiliation:
            name:Lanzhou University
            address:
               name:School of Nursing, Lanzhou University, Lanzhou, China
               type:PostalAddress
            type:Organization
      name:Qing Zhao
      affiliation:
            name:Lanzhou University
            address:
               name:School of Nursing, Lanzhou University, Lanzhou, China
               type:PostalAddress
            type:Organization
      name:Donghui Wang
      affiliation:
            name:Lanzhou University
            address:
               name:School of Nursing, Lanzhou University, Lanzhou, China
               type:PostalAddress
            type:Organization
      name:Shuaitong Li
      affiliation:
            name:Lanzhou University
            address:
               name:School of Nursing, Lanzhou University, Lanzhou, China
               type:PostalAddress
            type:Organization
      name:Junping Hu
      url:http://orcid.org/0000-0003-1412-6950
      affiliation:
            name:Lanzhou University
            address:
               name:School of Nursing, Lanzhou University, Lanzhou, China
               type:PostalAddress
            type:Organization
            name:Key Laboratory for Reproductive Medicine and Embryo
            address:
               name:The Reproductive Medicine Special Hospital of the 1st Hospital of Lanzhou University, Key Laboratory for Reproductive Medicine and Embryo, Lanzhou, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:School of Nursing, Lanzhou University, Lanzhou, China
      name:School of Nursing, Lanzhou University, Lanzhou, China
      name:The Reproductive Medicine Special Hospital of the 1st Hospital of Lanzhou University, Key Laboratory for Reproductive Medicine and Embryo, Lanzhou, China
      name:School of Nursing, Lanzhou University, Lanzhou, China
      name:School of Nursing, Lanzhou University, Lanzhou, China
      name:School of Nursing, Lanzhou University, Lanzhou, China
      name:School of Nursing, Lanzhou University, Lanzhou, China
      name:School of Nursing, Lanzhou University, Lanzhou, China
      name:School of Nursing, Lanzhou University, Lanzhou, China
      name:The Reproductive Medicine Special Hospital of the 1st Hospital of Lanzhou University, Key Laboratory for Reproductive Medicine and Embryo, Lanzhou, China
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(220)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.79s.

LINK . SPRINGER . COM {}