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Title[redir]:
Gut Microbiome-Linked Metabolites in the Pathobiology of Major Depression With or Without AnxietyโA Role for Bile Acids - PMC
Description:
The gut microbiome may play a role in the pathogenesis of neuropsychiatric diseases including major depressive disorder (MDD). Bile acids (BAs) are steroid acids that are synthesized in the liver from cholesterol and further processed by ...
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Keywords {๐}
acid, bas, google, scholar, pubmed, doi, bile, anxiety, gut, depression, pmc, article, secondary, cdca, participants, acids, free, primary, treatment, lca, hamilton, levels, hrsatotal, ratios, baseline, hrsd, rating, scale, severity, correlated, rho, synthesis, mdd, brain, study, microbiome, liver, metabolism, data, hrsasom, metabolites, pathway, fxr, symptoms, significantly, higher, item, human, analysis, figure,
Topics {โ๏ธ}
protein-coupled receptor responsive central nervous system gas chromatography/mass spectrometry hypothalamic-pituitary-adrenal system pmc beta search microbial-derived 7-keto-lca acts antibiotic-induced microbiota perturbation brain-derived neurotrophic factor hamilton anxiety scale amino acid n-acyltransferase [google scholar] foster nih grants p50-mh077083 pearson chi-squared test hypothalamic-pituitary-adrenal axis induce double-strand breaks medium-chain acyl-coenzyme data availability statement bacterially-derived secondary ba gut-bacteria-produced secondary bas bacterial 7ฮฑ-dehydroxylase removes steroid side-chain oxidation cdca-derived hyocholic acid post-mortem brain samples human bile acid-coa inborn errors article/supplementary material ethics statement rating scale lc/esi-ms/ms microbiota-deficient rodents resulted short-chain fatty acids microbiota-derived bile acids suggest gut-microbe composition involve gut-microbial dysbiosis license information pmcid secondary bacterially-produced bas secondary basโlithocholic acid gut-microbe-produced bas major depressive disorder mucosal immune system gut microbiome-linked metabolites microbiota-gut-brain axis brain-gut-microbiota axis continuous dependent variables produce enhanced toxicity hippocampal fxr plays data availability statements alter cns function severe depression-high anxiety hippocampal neuroglial reorganization
Questions {โ}
- BDNF expression in the hippocampus of maternally separated rats: does Bifidobacterium breve 6330 alter BDNF levels?
- Do Baseline BA Concentrations Distinguish Participants Who Reached Symptom Remission From Those Who Experienced Treatment Failure From 12 Weeks of Treatment?
- Do bacteria shape our development?
- Do baseline BA profiles distinguish MDD patients who achieved remission from those who failed to benefit after 12 weeks of treatment?
- Does symptom severity correlate with differential metabolism of BAs through the classical and alternate pathways?
- Is there a relationship between BA profiles and depressive and anxiety symptom severity?
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- Check the income stats for https://scholar.google.com/scholar_lookup?journal=JAMA%20Psychiatry&title=Baseline%20depression%20severity%20as%20moderator%20of%20depression%20outcomes%20between%20cognitive%20behavioral%20therapy%20vs%20pharmacotherapy:%20an%20individual%20patient%20data%20meta-analysis&author=E.%20S.%20Weitz&author=S.%20D.%20Hollon&author=J.%20Twisk&author=A.%20Van%20Straten&author=M.%20J.%20Huibers&volume=72&publication_year=2015&pages=1102-1109&pmid=26397232&doi=10.1001/jamapsychiatry.2015.1516&
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Analytics and Tracking {๐}
- Google Analytics
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Libraries {๐}
- jQuery
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Emails and Hosting {โ๏ธ}
Mail Servers:
- nihcesxway.hub.nih.gov
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- lhcns1.nlm.nih.gov
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CDN Services {๐ฆ}
- Ncbi