We are analyzing https://link.springer.com/article/10.1186/s12967-020-02356-2.

Title:
A systematic review of metabolomic dysregulation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis/Systemic Exertion Intolerance Disease (CFS/ME/SEID) | Journal of Translational Medicine
Description:
Background Chronic Fatigue Syndrome/Myalgic Encephalomyelitis/Systemic Exertion Intolerance Disease (CFS/ME/SEID) is a complex illness that has an unknown aetiology. It has been proposed that metabolomics may contribute to the illness pathogenesis of CFS/ME/SEID. In metabolomics, the systematic identification of measurable changes in small molecule metabolite products have been identified in cases of both monogenic and heterogenic diseases. Therefore, the aim of this systematic review was to evaluate if there is any evidence of metabolomics contributing to the pathogenesis of CFS/ME/SEID. Methods PubMed, Scopus, EBSCOHost (Medline) and EMBASE were searched using medical subject headings terms for Chronic Fatigue Syndrome, metabolomics and metabolome to source papers published from 1994 to 2020. Inclusion and exclusion criteria were used to identify studies reporting on metabolites measured in blood and urine samples from CFS/ME/SEID patients compared with healthy controls. The Joanna Briggs Institute Checklist was used to complete a quality assessment for all the studies included in this review. Results 11 observational case control studies met the inclusion criteria for this review. The primary outcome of metabolite measurement in blood samples of CFS/ME/SEID patients was reported in ten studies. The secondary outcome of urine metabolites was measured in three of the included studies. No studies were excluded from this review based on a low-quality assessment score, however there was inconsistency in the scientific research design of the included studies. Metabolites associated with the amino acid pathway were the most commonly impaired with significant results in seven out of the 10 studies. However, no specific metabolite was consistently impaired across all of the studies. Urine metabolite results were also inconsistent. Conclusion The findings of this systematic review reports that a lack of consistency with scientific research design provides little evidence for metabolomics to be clearly defined as a contributing factor to the pathogenesis of CFS/ME/SEID. Further research using the same CFS/ME/SEID diagnostic criteria, metabolite analysis method and control of the confounding factors that influence metabolite levels are required.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Health & Fitness
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,642,828 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure how the site profits.

Earning money isn't the goal of every website; some are designed to offer support or promote social causes. People have different reasons for creating websites. This might be one such reason. Link.springer.com has a revenue plan, but it's either invisible or we haven't found it.

Keywords {🔍}

cfsmeseid, studies, patients, metabolites, pubmed, article, metabolite, fatigue, review, criteria, metabolomics, google, scholar, chronic, included, syndrome, results, study, samples, systematic, research, analysis, urine, search, blood, identified, cas, quality, data, metabolism, central, assessment, table, pathogenesis, papers, case, including, compared, control, confounding, fukuda, metabolic, total, serum, syndromemyalgic, disease, number, myalgic, plasma, institute,

Topics {✒️}

chronic fatigue syndrome major biochemical pathways myalgic encephalomyelitis energy metabolism pathway article download pdf nuclear magnetic resonance chronic fatigue syndr intra-cellular signal transduction dysfunctional energy metabolism databases including pubmed major biochemical pathway relapsing–remitting symptom pattern amino acid metabolism teilah kathryn huth disease symptomatology perform metabolite analyses australian cross-sectional study low-quality assessment score full-text terms irritable bowel syndrome energy metabolism full access medical subject headings dysregulated metabolomic profile privacy choices/manage cookies marshall-gradisnik case definitions including oxidative stress pathways joanna briggs institute critical appraisal checklist genito-urinary impairment urinary excretion patterns blood metabolites—primary outcome disease pathogenesis health-related quality natalie eaton-fitch low-grade fever body mass index biochem mol med creative commons licence metabolite profiles article huth /seid participant selection international consensus criteria methods pubmed related subjects canadian consensus criteria revised criteria including sample size amino acid pathway

Questions {❓}

Metabolomics and metabolic diseases: where do we stand?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:A systematic review of metabolomic dysregulation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis/Systemic Exertion Intolerance Disease (CFS/ME/SEID)
         description:Chronic Fatigue Syndrome/Myalgic Encephalomyelitis/Systemic Exertion Intolerance Disease (CFS/ME/SEID) is a complex illness that has an unknown aetiology. It has been proposed that metabolomics may contribute to the illness pathogenesis of CFS/ME/SEID. In metabolomics, the systematic identification of measurable changes in small molecule metabolite products have been identified in cases of both monogenic and heterogenic diseases. Therefore, the aim of this systematic review was to evaluate if there is any evidence of metabolomics contributing to the pathogenesis of CFS/ME/SEID. PubMed, Scopus, EBSCOHost (Medline) and EMBASE were searched using medical subject headings terms for Chronic Fatigue Syndrome, metabolomics and metabolome to source papers published from 1994 to 2020. Inclusion and exclusion criteria were used to identify studies reporting on metabolites measured in blood and urine samples from CFS/ME/SEID patients compared with healthy controls. The Joanna Briggs Institute Checklist was used to complete a quality assessment for all the studies included in this review. 11 observational case control studies met the inclusion criteria for this review. The primary outcome of metabolite measurement in blood samples of CFS/ME/SEID patients was reported in ten studies. The secondary outcome of urine metabolites was measured in three of the included studies. No studies were excluded from this review based on a low-quality assessment score, however there was inconsistency in the scientific research design of the included studies. Metabolites associated with the amino acid pathway were the most commonly impaired with significant results in seven out of the 10 studies. However, no specific metabolite was consistently impaired across all of the studies. Urine metabolite results were also inconsistent. The findings of this systematic review reports that a lack of consistency with scientific research design provides little evidence for metabolomics to be clearly defined as a contributing factor to the pathogenesis of CFS/ME/SEID. Further research using the same CFS/ME/SEID diagnostic criteria, metabolite analysis method and control of the confounding factors that influence metabolite levels are required.
         datePublished:2020-05-13T00:00:00Z
         dateModified:2020-05-13T00:00:00Z
         pageStart:1
         pageEnd:14
         license:http://creativecommons.org/publicdomain/zero/1.0/
         sameAs:https://doi.org/10.1186/s12967-020-02356-2
         keywords:
            Chronic Fatigue Syndrome/Myalgic Encephalomyelitis/Systemic Exertion Intolerance Disease (CFS/ME/SEID)
            Metabolomics
            Metabolome
            Biomedicine
            general
            Medicine/Public Health
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12967-020-02356-2/MediaObjects/12967_2020_2356_Fig1_HTML.png
         isPartOf:
            name:Journal of Translational Medicine
            issn:
               1479-5876
            volumeNumber:18
            type:
               Periodical
               PublicationVolume
         publisher:
            name:BioMed Central
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Teilah Kathryn Huth
               url:http://orcid.org/0000-0002-3055-2290
               affiliation:
                     name:National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University
                     address:
                        name:National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University, Gold Coast, Australia
                        type:PostalAddress
                     type:Organization
                     name:University of Notre Dame
                     address:
                        name:School of Medicine, University of Notre Dame, Sydney, Australia
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Natalie Eaton-Fitch
               affiliation:
                     name:National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University
                     address:
                        name:National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University, Gold Coast, Australia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Donald Staines
               affiliation:
                     name:National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University
                     address:
                        name:National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University, Gold Coast, Australia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Sonya Marshall-Gradisnik
               affiliation:
                     name:National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University
                     address:
                        name:National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University, Gold Coast, Australia
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:A systematic review of metabolomic dysregulation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis/Systemic Exertion Intolerance Disease (CFS/ME/SEID)
      description:Chronic Fatigue Syndrome/Myalgic Encephalomyelitis/Systemic Exertion Intolerance Disease (CFS/ME/SEID) is a complex illness that has an unknown aetiology. It has been proposed that metabolomics may contribute to the illness pathogenesis of CFS/ME/SEID. In metabolomics, the systematic identification of measurable changes in small molecule metabolite products have been identified in cases of both monogenic and heterogenic diseases. Therefore, the aim of this systematic review was to evaluate if there is any evidence of metabolomics contributing to the pathogenesis of CFS/ME/SEID. PubMed, Scopus, EBSCOHost (Medline) and EMBASE were searched using medical subject headings terms for Chronic Fatigue Syndrome, metabolomics and metabolome to source papers published from 1994 to 2020. Inclusion and exclusion criteria were used to identify studies reporting on metabolites measured in blood and urine samples from CFS/ME/SEID patients compared with healthy controls. The Joanna Briggs Institute Checklist was used to complete a quality assessment for all the studies included in this review. 11 observational case control studies met the inclusion criteria for this review. The primary outcome of metabolite measurement in blood samples of CFS/ME/SEID patients was reported in ten studies. The secondary outcome of urine metabolites was measured in three of the included studies. No studies were excluded from this review based on a low-quality assessment score, however there was inconsistency in the scientific research design of the included studies. Metabolites associated with the amino acid pathway were the most commonly impaired with significant results in seven out of the 10 studies. However, no specific metabolite was consistently impaired across all of the studies. Urine metabolite results were also inconsistent. The findings of this systematic review reports that a lack of consistency with scientific research design provides little evidence for metabolomics to be clearly defined as a contributing factor to the pathogenesis of CFS/ME/SEID. Further research using the same CFS/ME/SEID diagnostic criteria, metabolite analysis method and control of the confounding factors that influence metabolite levels are required.
      datePublished:2020-05-13T00:00:00Z
      dateModified:2020-05-13T00:00:00Z
      pageStart:1
      pageEnd:14
      license:http://creativecommons.org/publicdomain/zero/1.0/
      sameAs:https://doi.org/10.1186/s12967-020-02356-2
      keywords:
         Chronic Fatigue Syndrome/Myalgic Encephalomyelitis/Systemic Exertion Intolerance Disease (CFS/ME/SEID)
         Metabolomics
         Metabolome
         Biomedicine
         general
         Medicine/Public Health
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12967-020-02356-2/MediaObjects/12967_2020_2356_Fig1_HTML.png
      isPartOf:
         name:Journal of Translational Medicine
         issn:
            1479-5876
         volumeNumber:18
         type:
            Periodical
            PublicationVolume
      publisher:
         name:BioMed Central
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Teilah Kathryn Huth
            url:http://orcid.org/0000-0002-3055-2290
            affiliation:
                  name:National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University
                  address:
                     name:National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University, Gold Coast, Australia
                     type:PostalAddress
                  type:Organization
                  name:University of Notre Dame
                  address:
                     name:School of Medicine, University of Notre Dame, Sydney, Australia
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Natalie Eaton-Fitch
            affiliation:
                  name:National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University
                  address:
                     name:National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University, Gold Coast, Australia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Donald Staines
            affiliation:
                  name:National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University
                  address:
                     name:National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University, Gold Coast, Australia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sonya Marshall-Gradisnik
            affiliation:
                  name:National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University
                  address:
                     name:National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University, Gold Coast, Australia
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Journal of Translational Medicine
      issn:
         1479-5876
      volumeNumber:18
Organization:
      name:BioMed Central
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University
      address:
         name:National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University, Gold Coast, Australia
         type:PostalAddress
      name:University of Notre Dame
      address:
         name:School of Medicine, University of Notre Dame, Sydney, Australia
         type:PostalAddress
      name:National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University
      address:
         name:National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University, Gold Coast, Australia
         type:PostalAddress
      name:National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University
      address:
         name:National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University, Gold Coast, Australia
         type:PostalAddress
      name:National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University
      address:
         name:National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University, Gold Coast, Australia
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Teilah Kathryn Huth
      url:http://orcid.org/0000-0002-3055-2290
      affiliation:
            name:National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University
            address:
               name:National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University, Gold Coast, Australia
               type:PostalAddress
            type:Organization
            name:University of Notre Dame
            address:
               name:School of Medicine, University of Notre Dame, Sydney, Australia
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Natalie Eaton-Fitch
      affiliation:
            name:National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University
            address:
               name:National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University, Gold Coast, Australia
               type:PostalAddress
            type:Organization
      name:Donald Staines
      affiliation:
            name:National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University
            address:
               name:National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University, Gold Coast, Australia
               type:PostalAddress
            type:Organization
      name:Sonya Marshall-Gradisnik
      affiliation:
            name:National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University
            address:
               name:National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University, Gold Coast, Australia
               type:PostalAddress
            type:Organization
PostalAddress:
      name:National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University, Gold Coast, Australia
      name:School of Medicine, University of Notre Dame, Sydney, Australia
      name:National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University, Gold Coast, Australia
      name:National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University, Gold Coast, Australia
      name:National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University, Gold Coast, Australia

External Links {🔗}(148)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

5.06s.

LINK . SPRINGER . COM {}