We are analyzing https://link.springer.com/article/10.1186/s40168-021-01101-1.

Title:
Review: microbial transformations of human bile acids | Microbiome
Description:
Bile acids play key roles in gut metabolism, cell signaling, and microbiome composition. While the liver is responsible for the production of primary bile acids, microbes in the gut modify these compounds into myriad forms that greatly increase their diversity and biological function. Since the early 1960s, microbes have been known to transform human bile acids in four distinct ways: deconjugation of the amino acids glycine or taurine, and dehydroxylation, dehydrogenation, and epimerization of the cholesterol core. Alterations in the chemistry of these secondary bile acids have been linked to several diseases, such as cirrhosis, inflammatory bowel disease, and cancer. In addition to the previously known transformations, a recent study has shown that members of our gut microbiota are also able to conjugate amino acids to bile acids, representing a new set of “microbially conjugated bile acids.” This new finding greatly influences the diversity of bile acids in the mammalian gut, but the effects on host physiology and microbial dynamics are mostly unknown. This review focuses on recent discoveries investigating microbial mechanisms of human bile acids and explores the chemical diversity that may exist in bile acid structures in light of the new discovery of microbial conjugations. Video Abstract
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Keywords {🔍}

bile, acid, bas, pubmed, article, acids, google, scholar, gut, cas, human, conjugated, microbial, cdca, amino, host, activity, salt, microbiota, hydrolase, microbiome, primary, clostridium, diversity, central, metabolism, microbes, glycine, capable, epimerization, disease, pool, conjugation, bsh, udca, accessed, taurine, dca, fig, bacteria, secondary, intestinal, oxidation, characterization, liver, deconjugation, fxr, potential, microbiol, research,

Topics {✒️}

12α-dihydroxy-5β-cholan-24-oic acid 12α-trihydroxy-5β-cholan-24-oic acid 7α-dihydroxy-5β-cholan-24-oic acid 7α-trihydroxy-5β-cholan-24-oic acid 7β-trihydroxy-5β-cholan-24-oic acid 3α-hydroxy-5β-cholan-24-oic acid 12β-trihydroxy-5β-cholan-24-oic acid /jfp/article-pdf/67/12/2772/1676188/0362-028x-67_12_2772 /science/article/abs/pii/s1388198107002156 /science/article/abs/pii/s0039128x05002308 /science/article/abs/pii/s0168165614008050 /science/article/abs/pii/s1383574204000560 /science/article/abs/pii/s0163725819301391 uplc-mrm-ms-validated method bacterium enterocloster bolteae nadph-dependent 7β-hydroxysteroid dehydrogenase yield 3-oxo-δ4-cholyl-coa bile acid profiles /science/article/pii/s0039128x97000433 /science/article/abs/pii/0263785596000185 /science/article/abs/pii/0005274476900681 /science/article/pii/s0039128x08002031 /science/article/abs/pii/0005276088902664 nadp-dependent 12β-hydroxysteroid dehydrogenase yielding 3-oxo-δ4-ca amino acid n-acyltransferase full size image 7-alpha-dehydroxylating bile acids 3-oxo-δ4-cholyl-coa /nar/article/47/d1/d614/5146204 12α-hydroxysteroid dehydrogenase activities amino acid-specific mechanisms position-specific hydroxysteroid dehydrogenase human conjugated ba pool increases /femsle/article-lookup/doi/10 encode 12α-hsdhs [35 bile-acid 7-alpha dehydratase tauro-beta-muricholic acid article download pdf org/cgi-bin/paper org/jem/article-pdf/123/2/413/1082316/413 integrated chemo-enzymatic route putative 12β-hsdh genes genome-based taxonomic classification human bile acid-coa /science/article/pii/0005276077901679 g-protein coupled receptors ba-amino acid conjugates health-related ba research lc-esi-ms/ms

Questions {❓}

Bile Acids: A pH Dependent Antibacterial System in the Gut?
One may wonder then, why do gut microbiota conjugate our bile acids?
Com/action/showPdf?
Com/science/article/abs/pii/0005274476900681?
Com/science/article/abs/pii/0005276088902664?
Com/science/article/abs/pii/0263785596000185?
Com/science/article/abs/pii/S0039128X05002308?
Com/science/article/abs/pii/S0163725819301391?
Com/science/article/abs/pii/S0168165614008050?
Com/science/article/abs/pii/S1383574204000560?
Com/science/article/abs/pii/S1388198107002156?
Com/science/article/pii/S0039128X97000433?
Org/cgi-bin/paper?

Schema {🗺️}

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          Enterocloster bolteae
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