We are analyzing https://link.springer.com/article/10.1007/s12035-018-1403-3.

Title:
Ferroptosis and Its Role in Diverse Brain Diseases | Molecular Neurobiology
Description:
Ferroptosis is a recently identified, iron-regulated, non-apoptotic form of cell death. It is characterized by cellular accumulation of lipid reactive oxygen species that ultimately leads to oxidative stress and cell death. Although first identified in cancer cells, ferroptosis has been shown to have significant implications in several neurologic diseases, such as ischemic and hemorrhagic stroke, Alzheimer’s disease, and Parkinson’s disease. This review summarizes current research on ferroptosis, its underlying mechanisms, and its role in the progression of different neurologic diseases. Understanding the role of ferroptosis could provide valuable information regarding treatment and prevention of these devastating diseases.
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Keywords {🔍}

pubmed, article, google, scholar, cas, central, ferroptosis, cell, disease, death, iron, brain, wang, biol, oxidative, cells, httpsdoiorgs, chen, parkinsons, cancer, res, sci, stress, stroke, mol, med, zhang, diseases, yang, neurol, role, lipid, liu, alzheimers, neurodegenerative, glutathione, neuronal, lee, human, sun, ischemic, chem, redox, mitochondrial, blood, peroxidation, kang, neurosci, intracerebral, hemorrhage,

Topics {✒️}

oncogenic-ras-harboring cancer cells month download article/chapter p62-keap1-nrf2 pathway protects glioma-induced brain edema mid-gestation fetal sheep central nervous system calcium-dependent glutamate cytotoxicity xct/slc7a11 dependent manner cystathionine-gamma-lyase function p53-independent tumor suppression nitric oxide-induced loss late-onset iron deposition nutrient-deprived cancer cells beta-amyloid precursor protein american heart association rotenone-induced oxidative stress genotype-selective antitumor agents de ferranti sd severe ischemic-anoxic insults bdnf-mediated nrf2 activation age-related neurodegenerative diseases full article pdf late-onset lipid peroxidation collagenase-induced intracerebral hemorrhage atf4-dependent upregulation atf4 promotes angiogenesis ferroptotic cell death dopaminergic neuroblastoma cells oxidative stress-dependent p53-mediated activity glutamate-induced cytotoxicity xct-dependent manner glutamate oxidative damage privacy choices/manage cookies cell death caused amyotrophic lateral sclerosis maturation-dependent vulnerability dixon sj del signore sj iron-dependent form enabling lipoxygenase generation nigral cell death scientific research program advancing accm research erastin-induced ferroptosis acute ischemic stroke hepatocellular carcinoma cells breast cancer cells increased oxidative damage diverse brain diseases

Questions {❓}

Armstrong JS, Khdour O, Hecht SM (2010) Does oxidative stress contribute to the pathology of Friedreich's ataxia?
Dixon SJ (2017) Ferroptosis: bug or feature?
Kang R, Tang D (2017) Autophagy and ferroptosis—what’s the connection?
Sfera A, Bullock K, Price A, Inderias L, Osorio C (2017) Ferrosenescence: the iron age of neurodegeneration?

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