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cells, cell, doi, slca, ferroptosis, erastin, death, fig, pubmed, google, scholar, pmc, data, rsl, cancer, article, melanoma, lipid, experiments, free, levels, gln, treated, overexpression, independent, mda, accumulation, expression, assay, targeting, glutaminolysis, glutamine, transfected, shown, regulates, ros, uptake, apoptosis, increased, important, measured, rslinduced, knockdown, akg, kit, figs, zhang, suppressed, inhibits, level,

Topics {✒️}

pcdh-cmv-mcs-ef1-puro lentiviral vector pcdh-cmv-mcs-ef1-puro vector ras–raf–mek–mapk pathway beckman-coulter ultracentrifuge xl-100k sided mann–whitney u-test glutamine-free dmem/f-12 medium oncogenic-ras-harboring cancer cells ice-cold phosphate-buffered saline l-g-glutamyl-p-nitroanilide quantitative real-time pcrs water-soluble formazan dye kras-regulated metabolic pathway real-time rt-pcr ngamma-aryl glutamine analogues [3h]-l-glutamine uptake iron-dependent cell death classical small-molecule inducers pmc beta search site-directed mutagenesis kit quantitative rt-pcr showing genotype-selective antitumor agents 200 nm [3h]-l-glutamine rsl3-induced cell death cell death-inducing activity quantitative reverse transcriptase-pcr ferroptotic cell death bio-rad ecl machine slc1 high-affinity glutamate glutaminolysis pathway blocked potential mir-137-binding sites cell death differ bodipy-c11 dye purchased ethical standards conflict rsl3-induced lipid formation fluorescent probes c11-bodipy cell death induced induced cell death reported mirna-mediated regulation supplementary materials included cell death inhibitor apoptosis inhibitor zvad-fmk targeting glutamine transport high-throughput screening beckman-coulter dtx880 nonapoptotic cell death full-length cdna cell surface transporter mirna-mediated downregulation anti-mir-137 increased pan-transaminases inhibitor aoa

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• https://doi.org/10.1038/emboj.2011.331 income
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