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Title:
The pentose phosphate pathway in health and disease | Nature Metabolism
Description:
The pentose phosphate pathway (PPP) is a glucose-oxidizing pathway that runs in parallel to upper glycolysis to produce ribose 5-phosphate and nicotinamide adenine dinucleotide phosphate (NADPH). Ribose 5-phosphate is used for nucleotide synthesis, while NADPH is involved in redox homoeostasis as well as in promoting biosynthetic processes, such as the synthesis of tetrahydrofolate, deoxyribonucleotides, proline, fatty acids and cholesterol. Through NADPH, the PPP plays a critical role in suppressing oxidative stress, including in certain cancers, in which PPP inhibition may be therapeutically useful. Conversely, PPP-derived NADPH also supports purposeful cellular generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) for signalling and pathogen killing. Genetic deficiencies in the PPP occur relatively commonly in the committed pathway enzyme glucose-6-phosphate dehydrogenase (G6PD). G6PD deficiency typically manifests as haemolytic anaemia due to red cell oxidative damage but, in severe cases, also results in infections due to lack of leucocyte oxidative burst, highlighting the dual redox roles of the pathway in free radical production and detoxification. This Review discusses the PPP in mammals, covering its roles in biochemistry, physiology and disease. In this Review, TeSlaa, Ralser, Fan and Rabinowitz comprehensively review the fundamental biochemical aspects of the pentose phosphate pathway and discuss its biological relevance in the context of physiology and pathology.
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nature portfolio journals privacy policy nature portfolio lncrna-encoded pep-ap attenuates hif-1α-induced metabolic reprograming high-rate pentose-phosphate pathways advertising nature metabolism team k-ras-driven tumor growth ludwig cancer research social media east africans colorado research partners glucose-6-phosphate dehydrogenase-deficient mice reprints leukocyte glucose-6-phosphate dehydrogenase glucose-6-phosphate dehydrogenase leads nad+/nadh redox state glucose-6-phosphate dehydrogenase deficiency glucose-6-phosphate dehydrogenase activity nitric oxide-mediated regulation africa development keap1–nrf2 regulatory axis long-range structural defects cancer research inhibits apoptosis-induced colitis α-ketoglutarate signaling pathway enhanced anti-tumor function hyperpolarized δ-[1-13c]gluconolactone author information authors publishing agreement de novo lipogenesis cellular energy metabolism nadph-dependent metabolic reprogramming differential site-based expression accepted manuscript version small-molecule g6pd activator nature+ nature 577 nature 614 nature 510 nature 376 nature 186 nature 527 nature kras-mutant lung adenocarcinoma personal data research mass isotopomer study
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