
NCBI . NLM . NIH . GOV {
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Title[redir]:
A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway - PMC
Description:
Glucose is catabolized by two fundamental pathways, glycolysis to make ATP and the oxidative pentose phosphate pathway to make NADPH. The first step of the oxidative pentose phosphate pathway is catalyzed by the enzyme glucose-6-phosphate ...
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Keywords {๐}
cells, gpd, doi, cell, figure, gpdi, nadph, google, scholar, supplementary, pubmed, pmc, article, free, human, activity, oxppp, dhea, mouse, cellular, active, media, activation, inhibitor, levels, experiments, dehydrogenase, inhibition, nadp, oxidative, neutrophils, mice, naรฏve, hglucose, min, production, hct, labeling, journal, assay, data, proliferation, protein, function, clone, glucose, enzyme, glucosephosphate, cytokine, analysis,
Topics {โ๏ธ}
reversed-phase ion-pairing chromatography n-terminal his6-tagged protein general antioxidant n-acetyl-cysteine plate-bound ฮฑcd3/ฮฑcd28 poor progression-free survival severe-glucose-6-phosphate dehydrogenase free palmitic acid plate-bound anti-cd3 bone marrow cells glucose-6-phosphate dehydrogenase deficiency mammalian glucose-6-phosphate dehydrogenase pmc beta search enzyme glucose-6-phosphate dehydrogenase pentose phosphate pathway glucose-6-phosphate dehydrogenase inhibition nat chem biol antioxidant n-acetyl-cysteine exhibit anti-proliferative effects monitor nadph-producing reactions clonal g6pd-null line oxppp diverts glucose-6-phospate estrogen-receptor independent mechanism c-digit scanner quadrupole-orbitrap mass spectrometer g6pd-tg mouse line michaelis-menten experiments nadp+ cd3ฮต/cd28 mab beads cell lines derived [google scholar] 2 designated g6pdi-neg-ctrl phorbol 12-myristate 13-acetate cell-active g6pd inhibitors small molecule inhibitors [u-13c]-glutamine revealed primary breast carcinoma glucose 6-phosphate dehydrogenase glucose-6-phosphate dehydrogenase develop metabolite reporter n-acetyl cysteine cellular target engagement undergoing thrombin cleavage g6pd-tg mouse studies paired guide rnas cell-active g6pd inhibitor cell cytokine production thermal shift assay small molecule inhibitor negative ion mode neutrophil oxidative burst hypomorphic cell line
Questions {โ}
- If T cells are most sensitive to acute G6PD inhibition, why are clinical manifestations of G6PD deficiency most apparent in RBCs?
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Analytics and Tracking {๐}
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- jQuery
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