
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Targeting oxidative pentose phosphate pathway prevents recurrence in mutant Kras colorectal carcinomas - PMC
Description:
Recurrent tumors originate from cancer stem cells (CSCs) that survive conventional treatments. CSCs consist of heterogeneous subpopulations that display distinct sensitivity to anticancer drugs. Such a heterogeneity presents a significant challenge ...
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Keywords {π}
cdcp, cells, tpi, fig, mukras, data, crc, cell, kras, cscs, crcs, ppp, tumor, mice, protein, expression, activity, cancer, mutant, treatment, tumors, epub, pubmed, google, scholar, sirt, doi, folfox, time, colorectal, recurrence, phosphate, homolog, determined, malonylation, stem, wtkras, analysis, flux, oxidative, pmc, enzyme, experiments, test, oncogene, demalonylation, dehydrogenase, weeks, usa, tif,
Topics {βοΈ}
reverse tetracycline-controlled transactivator small interfering rna protein kinase c-delta phosphoinositide 3-kinase /shi-scid il2rgnull /rac-alpha serine/threonine-protein kinase rac-alpha serine/threonine-protein kinase rosa26 cag-loxp-stop-loxp-tdtomato mice rosa26 cag-loxp-stop-loxp-tdtomato short hairpin rna reactive oxygen species si-kras phosphoglycerate kinase [pgk] liver-type fatty-acidβbinding protein rosa-cag-lsl-tdtomato mitogen-activated protein kinase src sirna targeting kras human embryonic kidney phosphoenolpyruvate r5p pgi succ rfs pi3k srm pga reverse-phase ion-pairing chromatography kras sirna ribose 5-phosphate pyruvate kinase [pk] phosphoglycerate kinase sirna hypoxia-inducible factor 2alpha residual cancer burden complement c1r/c1s erythrose 4-phosphate [e4p] balb/c-nu/nu mice lc-esi/ms/ms pyruvate kinase m2 posttranslational modifications hypoxia-inducible factor fluorescence-activated cell sorting magnetic-activated cell sorting female balb/c-nu mice rosa phosphoglucomutase [pgm] pyruvate kinase glyceraldehyde-3-phosphate dehydrogenase [gapdh] ribose
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