We are analyzing https://link.springer.com/article/10.1007/s00253-021-11314-x.

Title:
The pentose phosphate pathway in industrially relevant fungi: crucial insights for bioprocessing | Applied Microbiology and Biotechnology
Description:
Abstract The pentose phosphate pathway (PPP) is one of the most targeted pathways in metabolic engineering. This pathway is the primary source of NADPH, and it contributes in fungi to the production of many compounds of interest such as polyols, biofuels, carotenoids, or antibiotics. However, the regulatory mechanisms of the PPP are still not fully known. This review provides an insight into the current comprehension of the PPP in fungi and the limitations of this current understanding. It highlights how this knowledge contributes to targeted engineering of the PPP and thus to better performance of industrially used fungal strains. Key points • Type of carbon and nitrogen source as well as oxidative stress influence the PPP. • A complex network of transcription factors regulates the PPP. • Improved understanding of the PPP will allow to increase yields of bioprocesses.
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Keywords {🔍}

ppp, article, google, scholar, strain, pubmed, deletion, cas, nadph, nitrate, enzymes, pathway, phosphate, genes, metabolism, regulation, stress, activity, pentose, increased, expression, production, van, strains, nitrogen, gene, oxidative, increase, carbon, aspergillus, fungi, source, transcription, growth, dxylose, yeast, tps, response, tkl, hankinson, glucose, central, cerevisiae, cove, metabolic, glycolysis, rtg, zwf, involved, cell,

Topics {✒️}

/biorender-templates/t-5ed8278771111200ab35257a-glycolysis unraveling condition-dependent networks article download pdf de magalhães-rocha nm nano lc-ms/ms stre-mediated transcription control nitrate permease-encoding gene xlnr dna-binding site industrially relevant fungi relevant issues related nicotinamide adenine dinucleotide central metabolic fluxes article masi van den berg rpi-encoding gene rpia nitrate reductase-encoding genes trehalose-6-phosphate synthase tps1 review article addresses wild-type strain treated van peij nnme rich d-xylose medium privacy choices/manage cookies d-xylose catabolic genes central carbon metabolism genome-wide transcription data de groot pwj related subjects van kuyk pa d-xylulose kinase activity l-arabinose catabolic system pentose phosphate pathway pentose-phosphate pathway hydrogen peroxide reveal full size image called glucose-6-phosphate dehydrogenase van den dool h2o2-treated wild type pentose phosphate isomerase lc-ms/ms tandem mass spectrometry pentose catabolic pathway 10 nmol·ml−1·od600−1 350 nmol·ml−1·od600−1 van de vondervoort increased d-xylose consumption obtained strain showed mach-aigner contributions van boxtel aj financial support provided transcription factor involved

Questions {❓}

Thevelein JM, Hohmann S (1995) Trehalose synthase: guard to the gate of glycolysis in yeast?
Winderickx J, de Winde JH, Crauwels M, Hino A, Hohmann S, van Dijck P, Thevelein JM (1996) Regulation of genes encoding subunits of the trehalose synthase complex in Saccharomyces cerevisiae: novel variations of STRE-mediated transcription control?

Schema {🗺️}

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         description:The pentose phosphate pathway (PPP) is one of the most targeted pathways in metabolic engineering. This pathway is the primary source of NADPH, and it contributes in fungi to the production of many compounds of interest such as polyols, biofuels, carotenoids, or antibiotics. However, the regulatory mechanisms of the PPP are still not fully known. This review provides an insight into the current comprehension of the PPP in fungi and the limitations of this current understanding. It highlights how this knowledge contributes to targeted engineering of the PPP and thus to better performance of industrially used fungal strains. • Type of carbon and nitrogen source as well as oxidative stress influence the PPP. • A complex network of transcription factors regulates the PPP. • Improved understanding of the PPP will allow to increase yields of bioprocesses.
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         Industrially relevant fungi
         Yeast
         Filamentous fungi
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