
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Metabolic Regulation of Redox Status in Stem Cells - PMC
Description:
Significance: Metabolism-dependent generation of reactive oxygen species (ROS) and associated oxidative damage have been traditionally linked to impaired homeostasis and cellular death. Beyond the adverse effects of ROS accumulation, increasing ...
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Keywords {🔍}
stem, cells, cell, pubmed, google, scholar, doi, ros, differentiation, pmc, free, mitochondrial, article, oxygen, generation, metabolic, oxidative, embryonic, pluripotent, superoxide, production, metabolism, antioxidant, cellular, dna, reactive, complex, redox, damage, reprogramming, stress, regulation, species, including, reduced, human, glycolysis, electron, mitochondria, low, energy, pathway, repair, levels, mechanisms, fate, high, glutathione, phosphate, expression,
Topics {✒️}
nicotinamide adenine dinucleotide hif-1α promotes reprogramming factor-induced fibroblasts hif-1α thioredoxin-glutathione reductase mitochondrial transcription factor gpx glutathione reductase mitochondrial-targeted antioxidants mitocp/mitoctpo glutathione peroxidase glutathione peroxidase 2 support ipsc formation mitochondrial-specific glutathione nuclear pore complex cytosolic gr uv-induced dna damage nadh/nadp+ transhydrogenation mitochondrial-dependent metabolic pathways glutathione-s-transferase reprogramming-initiation events mediated glycolysis/pentose phosphate pathway pentose-phosphate pathway results ipsc glutamine-dependent reductive carboxylation oxidative stress-induced mutations gr amino-acid side chains lt-hematopoietic stem cells pmc beta search mgsh de souza-pinto nc hydrogen peroxide mitochondrial matrix mn-sod nadh-linked substrates lkb1-deficient cells display long-chain fatty acids mptp opening/closing mitochondrial glutathione mitochondrial-dependent oxidative processes exogenous diet-procured molecules long-term reconstitution activity enables lineage-specific differentiation cristae-poor mitochondria characteristic early mptp closure transition pentose phosphate pathway induce ros-dependent signaling substrate-rich environment supported glucose-6-phosphate dehydrogenase oxygen-sensitive transcriptional programs
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- https://github.com/ncbi income
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