
NCBI . NLM . NIH . GOV {
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Title[redir]:
Mitochondrial biogenesis and proteome remodeling promotes one carbon metabolism for T cell activation - PMC
Description:
Naïve T cell stimulation activates anabolic metabolism to fuel the transition from quiescence to growth and proliferation. Here we show that naïve CD4+ T cell activation induces a unique program of mitochondrial biogenesis and remodeling. Using mass ...
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Keywords {🔍}
cells, cell, mitochondrial, figure, activation, doi, carbon, metabolism, metabolic, shmt, mitochondria, proteins, pubmed, google, scholar, pmc, pathway, analysis, article, naïve, free, biogenesis, induced, pathways, purine, proliferation, mice, enzymes, activated, biosynthesis, postactivation, proteome, levels, induction, protein, serine, early, data, cancer, vivo, increased, compared, survival, units, gfp, fold, expression, labeled, control, remodeling,
Topics {✒️}
supplementary material nihms843012-supplement-supplement_1 plate-bound anti-cd3/anti-cd28 supplementary materials nihms843012-supplement-supplement_1 anti-cd3/anti-cd28 antibodies specific pathogen-free conditions anti-cd3/anti-cd28 van der windt t-test comparing wild-type pmc beta search c57bl/6 wild-type recipients uniformly labeled 13c6-glucose p53-dependent metabolic remodelling uniformly labeled 13c3-serine aicar-5-aminoimidazole carboxamide ribonucleotide foxp3 fix/perm kit de-novo purine biosynthesis c57bl/6 wild-type mice tnf-related immunoregulatory proteins double-stranded dna breaks wild-type recipient mice de-novo serine biosynthesis uniformly labeled 13c-serine treating immune-mediated diseases enzyme converts 5-formyl-thf assessed gfp+ antigen-specific references anderson dd wild-type c57bl/6 supplementary materials included 13c-labeled 10-formyl-thf fatty acid catabolism 2d2 tcr transgenic tcr-transgenic 2d2 quantitative pcr analysis cell receptor-mediated signal org/gsea/msigdb/annotate utilized live-cell microscopy target folate-related enzymes fatty acid oxidation idh1 mediates lipogenesis de novo biosynthesis direct d3-serine metabolism phosphatidylinositol-3 kinase/akt regulation 13c 10-formyl-thf molecules spare respiratory capacity martin-montalvo representative flow-cytometry plots proteome remodeling promotes incomplete molecular understanding cd28 costimulatory signal supplemental experimental procedures
Questions {❓}
- However, the role of mitochondrial proliferation in T cell activation and survival has not been well defined, and highlights a fundamental question: Do cells replicate mitochondria solely to increase their existing metabolic and energetic function, or does mitochondrial proliferation allow development of a new population of organelles with distinct and specialized function?
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Analytics and Tracking {📊}
- Google Analytics
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- jQuery
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Emails and Hosting {✉️}
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