
NCBI . NLM . NIH . GOV {
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Title[redir]:
Hematologic and systemic metabolic alterations due to Mediterranean class II G6PD deficiency in mice - PMC
Description:
Deficiency of glucose-6-phosphate dehydrogenase (G6PD) is the single most common enzymopathy, present in approximately 400 million humans (approximately 5%). Its prevalence is hypothesized to be due to conferring resistance to malaria. However, G6PD ...
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Keywords {๐}
doi, gpd, mice, rbcs, gpdmed, deficiency, pubmed, google, scholar, figure, pmc, article, free, human, blood, mouse, metabolic, activity, glucosephosphate, dehydrogenase, metabolism, humans, levels, rbc, decreased, ppp, data, organs, stress, phz, red, significant, storage, murine, oxidant, oxidative, analysis, metabolomics, metabolites, gpddeficient, differences, diamide, studies, cells, email, model, normal, analyses, posttransfusion, life,
Topics {โ๏ธ}
ultra-high-pressure liquid chromatography ubi-gfp [ubic-gfp c57bl/6-tg ice-cold methanol/acetonitrile/water glucose-6-phosphate dehydrogenase-derived nadph rna isolation/real-time pcr rabbit anti-human/mouse g6pd mass spectrometry-based metabolomics high-energy phosphate compounds human glucose-6-phosphate dehydrogenase glucose-6-phosphate dehydrogenase mouse ubic-gfp c57bl/6-tg glucose-6-phosphate dehydrogenase deficiency semi-targeted lipid analysis pmc beta search odd-numbered carbon atoms steady-state glucose-6-phosphate high-oxygen-consuming organs high-oxygen-demand organs g6pd-deficient red cells carnitine-conjugated fatty acids nadph-dependent lipid metabolism supplementary materials included data-dependent ms2 acquisition high-throughput quantitative metabolomics real-time quantitative pcr glucose-6-phosphate dehydrogenase glucose 6-phosphate dehydrogenase free fatty acids 13c2/13c3 lactate isotopologs vivo pulse-chase experiment nadph-dependent beta-oxidation g6pd-deficient humans encounter g6pd deficiencyโdependent alteration methods mol biol snap-frozen organ tissues full ms mode g6pd-deficient mouse model human g6pd-deficient subjects g6pd-deficient mouse rbcs rbc life span license information pmcid wt c57bl/6j mice adenosine triphosphate content mitochondrial redox sensing red blood cells including pls-da supplemental material cell signaling technology purkinje cell lineage exactive mass spectrometer
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