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Keywords {🔍}

carkl, doi, cells, figure, activation, google, scholar, pubmed, lps, metabolic, macrophages, macrophage, cell, kinase, figures, expression, pcarkl, metabolism, pmc, sedoheptulose, polarization, article, kinases, tnfα, control, free, glucose, ngml, data, supplemental, protein, mlike, cellular, ppp, raw, ecar, levels, activity, pctrl, experimental, procedures, immune, flux, response, observed, ocr, redox, primary, function, regulation,

Topics {✒️}

glucose-6p/fructose-6p [g6p/f6p] full-length open-reading-frame cis-reporting luciferase construct luciferase reporter assay revealed vivo site-directed biotinylation gsh/gssg-glo assay provided lps-induced tnfα-secretory response explored nfκb/socs/stat3 signaling mitochondrial iron-sulfur enzymes pmc beta search 13c-labeled molecules irrespective lps-stimulation increased glycolytic-flux continuous anti-inflammatory treatment defective nf-kappab activation transcription factor nf-kappa liquid chromatography-mass spectrometry coiled open-chain structure [google scholar] schnyder [google scholar] wassenberg �anti-inflammatory” signals activated pyridine nucleotides—small molecules l-arginine-dependent inhibition steady-state metabolomic time direct activation phases/fates anti-inflammatory gene expression rotenone-resistant oxygen consumption recombinant murine m-csf generate recombinant wild-type ikk-nf-kappab pathway activation-inducing kinases mapkapk3 subsequent q-rt-pcrs male c57bl/6j mice aged c57bl/6j mice lps-activated hepatic endothelial cell-free supernatant sedoheptulose-dependent atpase activity 1h/13c hsqc spectrum bone marrow-derived macrophages similar nad/nadh ratio macrophages expressing carkl_egfp lps-induced socs3 expression anti-inflammatory immune responses surface accessibility sites nf-κb activity measured mouse tnf-α/tnfsf1a il-10-regulated antiinflammatory response nad/nadh peak ratio lps-induced macrophage activation ethical animal license protocol carkl-dependent metabolic reprogramming

Questions {❓}

• And what of clinical relevance?
• Approaching the asymptote?

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