Here's how NATURE.COM makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

NATURE . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Nature.com Make Money
  6. How Much Does Nature.com Make
  7. Keywords
  8. Topics
  9. Questions
  10. Schema
  11. Social Networks
  12. External Links
  13. Analytics And Tracking
  14. Libraries
  15. Hosting Providers
  16. CDN Services

We are analyzing https://www.nature.com/articles/nrc.2015.17.

Title:
Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies | Nature Reviews Cancer
Description:
Research on the BCL-2-regulated apoptotic pathway has led to the development of small molecules called BH3-mimetics that bind to pro-survival BCL-2 proteins to induce apoptosis of malignant cells. This Timeline article describes the history of research on the BCL-2 family of proteins and their roles in cancer. The
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Education
  • Science
  • Telecommunications

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌆 Monumental Traffic: 20M - 50M visitors per month


Based on our best estimate, this website will receive around 42,554,915 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}


Display Ads {🎯}


The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

Ads are managed by yourbow.com. Particular relationships are as follows:

Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.com

Reseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.com

How Much Does Nature.com Make? {💰}


Display Ads {🎯}

$536,300 per month
Our calculations suggest that Nature.com earns between $357,503 and $983,134 monthly online from display advertisements.

Keywords {🔍}

pubmed, google, scholar, cas, article, cell, bcl, central, apoptosis, cancer, nature, death, family, strasser, cells, protein, science, mcl, bim, proteins, gene, bax, sci, human, proc, natl, acad, usa, mice, biol, survival, bclxl, bhonly, abt, mitochondrial, apoptotic, development, mol, lymphoma, oncogene, expression, lymphoid, proapoptotic, inhibitor, research, nat, cory, dev, leukemia, bak,

Topics {✒️}

permissions reprints nature portfolio privacy policy mammalian interleukin-1b-converting enzyme bcr-abl-expressing hematopoietic progenitor genome-wide array-based cgh author information authors advertising myc-driven b-cell lymphomagenesis bcl-2high/mcl-1low profile hemopoietic-specific early-response gene bcl-xl/bim fragment complex medical research council bcl-xl-bak peptide complex timeline article focuses partially bis-cpg-dependent bcr/abl+ leukemic cells medical research social media bcl-2-expressing breast tumors peri-implantation embryonic lethality somatic copy-number alteration targeted high-affinity inhibitor selective bcl-xl inhibitor anti-apoptotic context md organ-specific autoimmune disease death-inducing protein shares pro-survival bcl-2 proteins pre-b-cell leukemia potentiates sorafenib-induced apoptosis acute myeloid leukemia survival-promoting proteins bcl-2 human b-lymphoblastoid cells cellular survival-promoting proteins drug-treated cells die mammalian proto-oncogene bcl-2 p53-independent mechanisms inhibitable research microrna-125b promotes apoptosis hormone-resistant prostate cancer bcl-2-specific bh3 mimetic fas-induced hepatocellular apoptosis personal data bax channel-forming activity pro-apoptotic bcl-2 protein mir-193b regulates mcl-1 tyrosine kinase inhibitors p53-mediated apoptotic response bcl-2-related gene outer mitochondrial membrane

Questions {❓}

  • How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies
         description:Research on the BCL-2-regulated apoptotic pathway has led to the development of small molecules called BH3-mimetics that bind to pro-survival BCL-2 proteins to induce apoptosis of malignant cells. This Timeline article describes the history of research on the BCL-2 family of proteins and their roles in cancer. The 'hallmarks of cancer' are generally accepted as a set of genetic and epigenetic alterations that a normal cell must accrue to transform into a fully malignant cancer. It follows that therapies designed to counter these alterations might be effective as anti-cancer strategies. Over the past 30 years, research on the BCL-2-regulated apoptotic pathway has led to the development of small-molecule compounds, known as 'BH3-mimetics', that bind to pro-survival BCL-2 proteins to directly activate apoptosis of malignant cells. This Timeline article focuses on the discovery and study of BCL-2, the wider BCL-2 protein family and, specifically, its roles in cancer development and therapy.
         datePublished:2016-01-29T00:00:00Z
         dateModified:2016-01-29T00:00:00Z
         pageStart:99
         pageEnd:109
         sameAs:https://doi.org/10.1038/nrc.2015.17
         keywords:
            Apoptosis
            Oncogenes
            Targeted therapies
            Biomedicine
            general
            Cancer Research
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrc.2015.17/MediaObjects/41568_2016_Article_BFnrc201517_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrc.2015.17/MediaObjects/41568_2016_Article_BFnrc201517_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrc.2015.17/MediaObjects/41568_2016_Article_BFnrc201517_Fig3_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrc.2015.17/MediaObjects/41568_2016_Article_BFnrc201517_Fig4_HTML.jpg
         isPartOf:
            name:Nature Reviews Cancer
            issn:
               1474-1768
               1474-175X
            volumeNumber:16
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Alex R. D. Delbridge
               affiliation:
                     name:University of Melbourne
                     address:
                        name:Walter and Eliza Hall Institute of Medical Research and the Department of Medical Biology, University of Melbourne, Victoria, Australia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Stephanie Grabow
               affiliation:
                     name:University of Melbourne
                     address:
                        name:Walter and Eliza Hall Institute of Medical Research and the Department of Medical Biology, University of Melbourne, Victoria, Australia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Andreas Strasser
               affiliation:
                     name:University of Melbourne
                     address:
                        name:Walter and Eliza Hall Institute of Medical Research and the Department of Medical Biology, University of Melbourne, Victoria, Australia
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:David L. Vaux
               affiliation:
                     name:University of Melbourne
                     address:
                        name:Walter and Eliza Hall Institute of Medical Research and the Department of Medical Biology, University of Melbourne, Victoria, Australia
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies
      description:Research on the BCL-2-regulated apoptotic pathway has led to the development of small molecules called BH3-mimetics that bind to pro-survival BCL-2 proteins to induce apoptosis of malignant cells. This Timeline article describes the history of research on the BCL-2 family of proteins and their roles in cancer. The 'hallmarks of cancer' are generally accepted as a set of genetic and epigenetic alterations that a normal cell must accrue to transform into a fully malignant cancer. It follows that therapies designed to counter these alterations might be effective as anti-cancer strategies. Over the past 30 years, research on the BCL-2-regulated apoptotic pathway has led to the development of small-molecule compounds, known as 'BH3-mimetics', that bind to pro-survival BCL-2 proteins to directly activate apoptosis of malignant cells. This Timeline article focuses on the discovery and study of BCL-2, the wider BCL-2 protein family and, specifically, its roles in cancer development and therapy.
      datePublished:2016-01-29T00:00:00Z
      dateModified:2016-01-29T00:00:00Z
      pageStart:99
      pageEnd:109
      sameAs:https://doi.org/10.1038/nrc.2015.17
      keywords:
         Apoptosis
         Oncogenes
         Targeted therapies
         Biomedicine
         general
         Cancer Research
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrc.2015.17/MediaObjects/41568_2016_Article_BFnrc201517_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrc.2015.17/MediaObjects/41568_2016_Article_BFnrc201517_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrc.2015.17/MediaObjects/41568_2016_Article_BFnrc201517_Fig3_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrc.2015.17/MediaObjects/41568_2016_Article_BFnrc201517_Fig4_HTML.jpg
      isPartOf:
         name:Nature Reviews Cancer
         issn:
            1474-1768
            1474-175X
         volumeNumber:16
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Alex R. D. Delbridge
            affiliation:
                  name:University of Melbourne
                  address:
                     name:Walter and Eliza Hall Institute of Medical Research and the Department of Medical Biology, University of Melbourne, Victoria, Australia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Stephanie Grabow
            affiliation:
                  name:University of Melbourne
                  address:
                     name:Walter and Eliza Hall Institute of Medical Research and the Department of Medical Biology, University of Melbourne, Victoria, Australia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Andreas Strasser
            affiliation:
                  name:University of Melbourne
                  address:
                     name:Walter and Eliza Hall Institute of Medical Research and the Department of Medical Biology, University of Melbourne, Victoria, Australia
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:David L. Vaux
            affiliation:
                  name:University of Melbourne
                  address:
                     name:Walter and Eliza Hall Institute of Medical Research and the Department of Medical Biology, University of Melbourne, Victoria, Australia
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Nature Reviews Cancer
      issn:
         1474-1768
         1474-175X
      volumeNumber:16
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Melbourne
      address:
         name:Walter and Eliza Hall Institute of Medical Research and the Department of Medical Biology, University of Melbourne, Victoria, Australia
         type:PostalAddress
      name:University of Melbourne
      address:
         name:Walter and Eliza Hall Institute of Medical Research and the Department of Medical Biology, University of Melbourne, Victoria, Australia
         type:PostalAddress
      name:University of Melbourne
      address:
         name:Walter and Eliza Hall Institute of Medical Research and the Department of Medical Biology, University of Melbourne, Victoria, Australia
         type:PostalAddress
      name:University of Melbourne
      address:
         name:Walter and Eliza Hall Institute of Medical Research and the Department of Medical Biology, University of Melbourne, Victoria, Australia
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Alex R. D. Delbridge
      affiliation:
            name:University of Melbourne
            address:
               name:Walter and Eliza Hall Institute of Medical Research and the Department of Medical Biology, University of Melbourne, Victoria, Australia
               type:PostalAddress
            type:Organization
      name:Stephanie Grabow
      affiliation:
            name:University of Melbourne
            address:
               name:Walter and Eliza Hall Institute of Medical Research and the Department of Medical Biology, University of Melbourne, Victoria, Australia
               type:PostalAddress
            type:Organization
      name:Andreas Strasser
      affiliation:
            name:University of Melbourne
            address:
               name:Walter and Eliza Hall Institute of Medical Research and the Department of Medical Biology, University of Melbourne, Victoria, Australia
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:David L. Vaux
      affiliation:
            name:University of Melbourne
            address:
               name:Walter and Eliza Hall Institute of Medical Research and the Department of Medical Biology, University of Melbourne, Victoria, Australia
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Walter and Eliza Hall Institute of Medical Research and the Department of Medical Biology, University of Melbourne, Victoria, Australia
      name:Walter and Eliza Hall Institute of Medical Research and the Department of Medical Biology, University of Melbourne, Victoria, Australia
      name:Walter and Eliza Hall Institute of Medical Research and the Department of Medical Biology, University of Melbourne, Victoria, Australia
      name:Walter and Eliza Hall Institute of Medical Research and the Department of Medical Biology, University of Melbourne, Victoria, Australia
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

Social Networks {👍}(2)

External Links {🔗}(650)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Prism.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mxa-002c5801.gslb.pphosted.com
  • mxb-002c5801.gslb.pphosted.com

Name Servers:

  • pdns1.ultradns.net
  • pdns2.ultradns.net
  • pdns3.ultradns.org
  • pdns4.ultradns.org
  • pdns5.ultradns.info
  • pdns6.ultradns.co.uk

CDN Services {📦}

  • Crossref

5.21s.