
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Mcl-1 is essential for the survival of plasma cells - PMC
Description:
The long-term survival of plasma cells is entirely dependent on signals derived from their environment. These extrinsic factors presumably induce and sustain the expression of antiapoptotic proteins of the Bcl-2 family. It is uncertain whether there ...
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Keywords {đ}
cells, plasma, doi, expression, mcl, bone, marrow, mice, cell, bcma, survival, pubmed, google, scholar, fig, bcl, spleen, deletion, immunol, pmc, analysis, blimp, tamoxifen, article, family, naive, data, experiments, differentiation, germinal, human, april, wildtype, free, encoding, vivo, supplementary, total, members, lower, treatment, bcll, isolated, flow, cytometry, mclflcreert, day, factors, gfp, longlived,
Topics {âď¸}
np-specific antibodyâsecreting cells np-specific antibody-secreting cells methods nihms579728-supplement-supplemental_figures_and_methods tumor-necrosis factor superfamily antigen-specific plasma cells mixedâbone marrow chimeras enzyme-linked immunospot assay enzyme-linked immunosorbent assay bone marrowâresident eosinophils36 plasma cellâderived cancers long-lived plasma cell plasma cellâdifferentiating conditions30 plasma cellâspecific gene secondary lymphoid organs [pubmed] [google scholar] pmc beta search np-specific immunoglobulin g1 mcl1fl/flcreert2 bone marrow long-lived plasma cells eliza hall institute enzyme-linked immunosorbent assays potent anti-apoptotic factor plasma cellâdifferentiating conditions ligand-receptor pairs contribute plasma cellâsurvival program estrogen receptorâmediated deletion np-specific plasma cells blimp-1int plasma blasts plasma cellâsurvival pathway immuno-magnetically selected naive loxp-flanked mcl1 allele pre-existing plasma cells22 total antibody-secreting cells antigen-specific antibodies quantitative real-time pcr bone marrow wild-type wild-type bone marrow loxp-flanked mcl1 alleles online methods mice fewer plasma cells loxp-flanked bcl2l1 alleles april-mediated signaling resulted cre recombinaseâmediated deletion bone marrowâreconstituted mice hamster antiâmouse bcl-2 wild-type plasma cells blimp-1hi plasma cells cd19+pna+ germinal center rat antiâmouse mcl-1 including il-6âil-6 receptor
Questions {â}
- B-cell memory: are subsets necessary?
- How does this model account for plasma cells present in the bone marrow of Bcmaâ/â mice, albeit at lower frequency and with lower expression of Mcl-1 than that of wild-type mice?
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