
NCBI . NLM . NIH . GOV {
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Title[redir]:
Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax) - PMC
Description:
The anti-apoptotic protein MCL-1 is a key regulator of cancer cell survival and a known resistance factor for small-molecule BCL-2 family inhibitors such as ABT-263 (navitoclax), making it an attractive therapeutic target. However, directly ...
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Keywords {🔍}
mcl, cell, cells, doi, pubmed, google, scholar, cancer, inhibitors, bcl, pmc, article, protein, free, apoptosis, lines, inhibitor, proteins, family, abt, molecules, figure, data, bclxl, usa, survival, affinity, concentrations, selective, navitoclax, activity, compounds, treated, chem, smallmolecule, supplementary, small, complexes, multiple, mcldependent, death, assays, biol, potent, antiapoptotic, interactions, experiments, cellular, antibody, effect,
Topics {✒️}
immunoprecipitation–enzyme-linked immunosorbent assay del gaizo moore tb-labeled anti-gst antibody bcl-xl–bcl-xs interactions measured untranslated region sulfo-tagged anti-rabbit antibody tr-fret anti-β-actin clone ac-15 coding sequence secondary anti-rabbit-hrp causing concentration-dependent elevations vp16ad–bcl-xs fusion proteins high-affinity protein–protein interactions [doi] [pubmed] mei small-molecule bh3 mimetic bcl-2/bcl-xl inhibitor navitoclax induced dose-dependent redistribution bcl-2/bcl-xl inhibitors abt-737 generate small-molecule inhibitors validating small-molecule inhibitors implementing small-molecule inhibitors indole-2-carboxylic acid analogs small-molecule bh3 mimetics x-linked inhibitor selective small-molecule inhibitors mcl-1-dependent cell lines indole-2-carboxylic acid core pmc beta search pan-caspase inhibitor qvd maintains anti-tumor efficacy small-molecule mcl-1 inhibitors α/β-peptide foldamers rabbit anti-bim antibody supplementary information click demonstrating anti-tumor activity achieves anti-tumor activity intensive structure-based efforts cell-active mcl-1 inhibitors egfp-bcl-2 family proteins selective bcl-xl inhibitor biotinylated anti-mcl-1 antibody anti-noxa clone 114c307 anti-mouse-hrp antibodies anti-bcl-xl clone 4 mesoscale electrochemiluminescence assay somatic copy-number alteration nsclc cell lines bcl-xl-selective inhibitors expressing paired gal4dbd–mcl-1 disrupt endogenous mcl-1–bh3
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