
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53 - PMC
Description:
c-MYC is abnormally overexpressed in many human cancers. Kelly et al. discover that MCL-1 is essential to sustain c-MYC-driven mouse lymphomas. MCL-1 blockade killed c-MYC-driven human Burkitt lymphoma cells, even those bearing mutations in p53, but ...
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Keywords {🔍}
mcl, lymphomas, lymphoma, cells, mice, cell, doi, pubmed, google, scholar, burkitt, expression, human, control, fig, growth, pmc, bcl, eμmyc, survival, mutations, article, tumor, free, loss, protein, lines, mouse, cmycdriven, bclxl, transplanted, analysis, deletion, tamoxifen, sustained, eμmyccreertmclflfl, clone, proteins, mclfl, prosurvival, treatment, bims, gene, pathway, bclx, recipient, cancer, detect, genes, strasser,
Topics {✒️}
pan-caspase inhibitor qvd-oph c-myc/igl chromosomal translocations accelerate c-myc-driven lymphomagenesis pi-negative/gfp-positive viable cells viable/gfp-positive dox-treated cells c-myc-driven burkitt lymphoma c-myc-driven lymphomas depends myc-driven b-cell lymphomagenesis clonal sig− pre-b-cell c-myc-driven lymphoma cells c-myc-driven human cancers c-myc-driven mouse lymphomas p53-mediated cell-cycle arrest transcriptional regulator c-myc viable/gfp-positive untreated cells c-myc-driven lymphomagenesis eμ-myc-induced lymphoma development mcl-1fl/fl lymphoma cells pi-negative/gfp-positive cells translocations involving c-myc deregulated c-myc expression bcl-xfl/fl lymphoma cells c-myc-driven mouse c-myc-driven cancers medical research council pmc beta search allowing long-term survival c-myc-driven lymphomas c57bl/6xsjl-derived oocytes generating kaplan-meier plots c-myc oncogene driven escaped cre-mediated deletion c-myc-driven tumorigenesis aggressive myc-driven lymphomas c57bl/6j-tyrc-2j hematopoietic stem/progenitor cells embo short-term fellowship bio-rad bradford assay gfp-luc lentiviral vector inducible cre-mediated deletion virus-producing 293t cells somatic copy-number alteration ivis live-imaging system mixed c57bl/6x129sv background mixed c57bl/6xsjl background hydrophobic ligand-binding groove c-myc oncogene perturbs eμ-myc lymphoma cells prevent oncogenic stress-induced permitting single-cell analysis
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