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Title[redir]:
BH3-only proteins Puma and Bim are rate-limiting for γ-radiationā and glucocorticoid-induced apoptosis of lymphoid cells in vivo - PMC
Description:
Numerous p53 target genes have been implicated in DNA damageāinduced apoptosis signaling, but proapoptotic Bcl-2 (B-cell leukemia 2) family members of the BH3 (Bcl-2 homolog region [BH] 3)āonly subgroup appear to play the critical initiating role. ...
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Keywords {š}
cells, puma, bim, apoptosis, cell, figure, doi, pubmed, google, scholar, bcl, animals, thymocytes, γradiation, death, lymphocytes, bhonly, mice, sections, noxa, vivo, treatment, mature, loss, pmc, article, proapoptotic, role, apoptotic, versus, proteins, dna, gcs, tunel, lymphoid, thymic, response, hours, analysis, absence, γradiationinduced, data, free, blood, strasser, family, damage, induced, effects, protein,
Topics {āļø}
terminal deoxynucleotidyl transferase immature b220+sigm-cd43- pre immature cd4+8+ double-positive identify pre-b-cell precursors fluorescence-conjugated antibodies specific cd4+8+ double-positive cells investigate γ-radiationāinduced apoptosis pmc beta search vav-bcl2ātransgenic mice30 preparing single-cell suspensions b220+sigm+cd43- pre b220+sigm-cd43- pre b220+sigm-cd43- pre cell typeāspecific manner cell typeāspecific protection stress-induced p53 runs bim/puma double-deficient thymocytes fas-induced hepatocellular apoptosis bcl-2-inhibitable pathway mediated wt versus vav-bcl2 rate-limiting proapoptotic molecule vav-bcl2ātransgenic mice t-cell immune responses lymphoma-derived cell lines transcription-independent death program free prosurvival bcl-2 vav-bcl2ātransgenic animals γ-radiationāinduced death dna damageāinduced apoptosis dna-damageāinduced apoptosis γ-radiationāinduced apoptosis death receptorāmediated killing single-cell suspensions stained supplementary materials included b220+igm-cd43- pre fluorescence-conjugated antibodies b-cell precursors bcl-2 transgene inhibits b-cell leukemia 2 γ-radiationāinduced activation p53-independent mechanisms inhibitable license information pmcid hematopoietic cell types γ-radiation requires p53 antibodies recognizing b220 vav-bcl2 transgene p53-mediated apoptotic response monoclonal antibodies conjugated single-cell suspensions prosurvival family members
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