NCBI . NLM . NIH . GOV {
}
We began analyzing https://pmc.ncbi.nlm.nih.gov/articles/PMC2736138/, but it redirected us to https://pmc.ncbi.nlm.nih.gov/articles/PMC2736138/. The analysis below is for the second page.
Title[redir]:
Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis - PMC
Description:
Mitochondrial outer membrane permeabilisation (MOMP) is the point of no return in many forms of apoptotic cell death. The killing effect of MOMP is twofold; it both initiates a proteolytic cascade of pro-apoptotic enzymes and damages mitochondrial ...
Title[redir]:
Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis - PMC
Description:
Mitochondrial outer membrane permeabilisation (MOMP) is the point of no return in many forms of apoptotic cell death. The killing effect of MOMP is twofold; it both initiates a proteolytic cascade of pro-apoptotic enzymes and damages mitochondrial ...
Matching Content Categories {π}
- Science
- Fitness & Wellness
- Education
Content Management System {π}
What CMS is ncbi.nlm.nih.gov built with?
Custom-built
No common CMS systems were detected on Ncbi.nlm.nih.gov, and no known web development framework was identified.
Traffic Estimate {π}
What is the average monthly size of ncbi.nlm.nih.gov audience?
π Phenomenal Traffic: 5M - 10M visitors per month
Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.
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How Does Ncbi.nlm.nih.gov Make Money? {πΈ}
We don't see any clear sign of profit-making.
Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Ncbi.nlm.nih.gov has a secret sauce for making money, but we can't detect it yet.
Keywords {π}
bax, bak, proteins, doi, pubmed, google, scholar, bcl, apoptosis, cell, mitochondrial, pmc, domain, activation, death, prosurvival, family, article, groove, free, activated, membrane, fig, biol, protein, model, hydrophobic, bhgroove, bhonly, momp, proapoptotic, pore, binding, members, apoptotic, form, cells, Ξ±helices, pathway, interaction, tbid, conformational, exposure, change, youle, role, interactions, mitochondria, function, complex,
Topics {βοΈ}
cell-surface-expressed death receptors p38 kinase-mediated phosphorylation bcl-xl-bak peptide complex bcl-xl/bim fragment complex pro-apoptotic targets show pmc beta search c-terminal hydrophobic transmembrane c-terminal membrane anchor membrane-targeted death ligand Ξ±1-Ξ±2 interhelical loop drug-treated cells die active-conformation-specific antibody pro-apoptotic cleavage products amino-acid substitution pro-apoptotic mutant form c-terminal tm domains pro-survival bcl-2 members free bh3 domain inhibiting bak auto-oligomerization bcl-2 pro-survival proteins pro-survival bcl-2 proteins bid-induced open conformer pro-survival protein ced-9 c-terminal transmembrane pro-survival proteins bound pro-apoptotic protein bak fas-induced hepatocellular apoptosis mitochondrial outer membrane outer mitochondrial membrane helix homo-oligomerization domain membrane-inserted Ξ±-helices cell damage-induced conformational crucial docking site tail-anchored proteins tumour necrosis factor regulate mitochondrial fission sensitise bakβ/βbaxβ/β fibroblasts pro-apoptotic factors n-terminus β epitopes fatal hepatitis mediated bcl-2-regulated apoptosis switch caspase-independent cell death bax pro-apoptotic function license information pmcid highly selective subset c-terminal region pro-apoptotic protein short-lived nematode pro-survival protein pro-apoptotic enzymes
Questions {β}
- Does the conformational change of Bak and Bax distinguish them from pro-survival proteins?
- How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?
- How do Bax and Bak lead to permeabilization of the outer mitochondrial membrane?
- Might BH3 exposure, and thus the ability to form homo-oligomers, distinguish Bak and Bax from the pro-survival proteins and thereby explain why their functions oppose that of pro-survival proteins?
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Analytics and Tracking {π}
- Google Analytics
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Emails and Hosting {βοΈ}
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CDN Services {π¦}
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