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NATURE . COM {}

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We are analyzing https://www.nature.com/articles/nrc.2015.17.

Title:
Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies | Nature Reviews Cancer
Description:
Research on the BCL-2-regulated apoptotic pathway has led to the development of small molecules called BH3-mimetics that bind to pro-survival BCL-2 proteins to induce apoptosis of malignant cells. This Timeline article describes the history of research on the BCL-2 family of proteins and their roles in cancer. The
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Education
  • Science
  • Telecommunications

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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Display Ads {🎯}


The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

Ads are managed by yourbow.com. Particular relationships are as follows:

Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.com

Reseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.com

How Much Does Nature.com Make? {💰}


Display Ads {🎯}

$63,100 per month
Our calculations suggest that Nature.com earns between $42,042 and $115,616 monthly online from display advertisements.

Keywords {🔍}

pubmed, google, scholar, cas, article, cell, bcl, central, apoptosis, cancer, nature, death, family, strasser, cells, protein, science, mcl, bim, proteins, gene, bax, sci, human, proc, natl, acad, usa, mice, biol, survival, bclxl, bhonly, abt, mitochondrial, apoptotic, development, mol, lymphoma, oncogene, expression, lymphoid, proapoptotic, inhibitor, research, nat, cory, dev, leukemia, bak,

Topics {✒️}

permissions reprints nature portfolio privacy policy mammalian interleukin-1b-converting enzyme bcr-abl-expressing hematopoietic progenitor genome-wide array-based cgh author information authors advertising myc-driven b-cell lymphomagenesis bcl-2high/mcl-1low profile hemopoietic-specific early-response gene bcl-xl/bim fragment complex medical research council bcl-xl-bak peptide complex timeline article focuses partially bis-cpg-dependent bcr/abl+ leukemic cells medical research social media bcl-2-expressing breast tumors peri-implantation embryonic lethality somatic copy-number alteration targeted high-affinity inhibitor selective bcl-xl inhibitor anti-apoptotic context md organ-specific autoimmune disease death-inducing protein shares pro-survival bcl-2 proteins pre-b-cell leukemia potentiates sorafenib-induced apoptosis acute myeloid leukemia survival-promoting proteins bcl-2 human b-lymphoblastoid cells cellular survival-promoting proteins drug-treated cells die mammalian proto-oncogene bcl-2 p53-independent mechanisms inhibitable research microrna-125b promotes apoptosis hormone-resistant prostate cancer bcl-2-specific bh3 mimetic fas-induced hepatocellular apoptosis personal data bax channel-forming activity pro-apoptotic bcl-2 protein mir-193b regulates mcl-1 tyrosine kinase inhibitors p53-mediated apoptotic response bcl-2-related gene outer mitochondrial membrane

Questions {❓}

  • How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?

Schema {🗺️}

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         description:Research on the BCL-2-regulated apoptotic pathway has led to the development of small molecules called BH3-mimetics that bind to pro-survival BCL-2 proteins to induce apoptosis of malignant cells. This Timeline article describes the history of research on the BCL-2 family of proteins and their roles in cancer. The 'hallmarks of cancer' are generally accepted as a set of genetic and epigenetic alterations that a normal cell must accrue to transform into a fully malignant cancer. It follows that therapies designed to counter these alterations might be effective as anti-cancer strategies. Over the past 30 years, research on the BCL-2-regulated apoptotic pathway has led to the development of small-molecule compounds, known as 'BH3-mimetics', that bind to pro-survival BCL-2 proteins to directly activate apoptosis of malignant cells. This Timeline article focuses on the discovery and study of BCL-2, the wider BCL-2 protein family and, specifically, its roles in cancer development and therapy.
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      headline:Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies
      description:Research on the BCL-2-regulated apoptotic pathway has led to the development of small molecules called BH3-mimetics that bind to pro-survival BCL-2 proteins to induce apoptosis of malignant cells. This Timeline article describes the history of research on the BCL-2 family of proteins and their roles in cancer. The 'hallmarks of cancer' are generally accepted as a set of genetic and epigenetic alterations that a normal cell must accrue to transform into a fully malignant cancer. It follows that therapies designed to counter these alterations might be effective as anti-cancer strategies. Over the past 30 years, research on the BCL-2-regulated apoptotic pathway has led to the development of small-molecule compounds, known as 'BH3-mimetics', that bind to pro-survival BCL-2 proteins to directly activate apoptosis of malignant cells. This Timeline article focuses on the discovery and study of BCL-2, the wider BCL-2 protein family and, specifically, its roles in cancer development and therapy.
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