
PMC . NCBI . NLM . NIH . GOV {
}
Title:
Signal Transduction to the Permeability Transition Pore - PMC
Description:
The permeability transition pore (PTP) is an inner mitochondrial membrane channel that has been thoroughly characterized functionally, yet remains an elusive molecular entity. The best characterized PTP-regulatory component, cyclophilin (CyP) D, is ...
Website Age:
27 years and 8 months (reg. 1997-10-02).
Matching Content Categories {📚}
- Science
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Custom-built
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🌠 Phenomenal Traffic: 5M - 10M visitors per month
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How Does Pmc.ncbi.nlm.nih.gov Make Money? {💸}
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Keywords {🔍}
doi, ptp, mitochondrial, pubmed, google, scholar, pore, cell, opening, mitochondria, cypd, pmc, permeability, transition, death, article, free, kinase, gskβ, phosphorylation, cells, channel, protein, vdac, inhibition, apoptosis, disease, regulation, ant, matrix, akt, membrane, cyclophilin, proteins, survival, bernardi, activation, pathways, molecular, ros, activity, csa, components, mice, injury, reperfusion, tumor, trap, role, open,
Topics {✒️}
reactive oxygen species g-protein coupled receptors protein-coupled receptor activation phosphatase pp2cm mitochondrial phosphate carrier adenine nucleotide translocator kinase/phosphatase signal transduction kinase/phosphatase signaling pathways receptor tyrosine kinase receptor tyrosine kinases kinase/phosphatase signalling pmc beta search glycogen synthase kinase-3beta v-ki-ras dependent transformation pro-apoptotic protein bax death receptor-induced hepatitis ser/thr kinase pink1 pp2a potentiates chemotherapy-induced cytotoxicity permeability coefficients pcl/pk≈7–18 csa-sensitive pt glycogen synthase kinase-3 outer mitochondrial membrane display cation-selective conductances plasma membrane “maxi-clchannels” pro-apoptotic bax/bak proteins voltage-dependent anion channels cardiac ischemia/reperfusion injury voltage-dependent anion channel potent anti-apoptotic “porekeeper” protein multimers assemble specific tyrosine increases targeting mitochondrial atp-sensitive double-edged sword acting mitochondrial permeability transition shp-1 exhibits antigen-stimulated mast cells hypoxic-ischemic brain injury permeability transition occurs post-ischemic myocardial reperfusion pro-apoptotic bax/bak ptp-induced mitochondrial damage high protein concentration death/survival mitochondrial rheostat akt-erk-gsk3 axis apoptosis-inducing antitumor efficacy permeability transition pore csa-sensitive mitochondrial depolarization mitochondrial-dependent cell death shrna-mediated knockdown
Questions {❓}
- What is the mitochondrial permeability transition pore?
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