We are analyzing https://link.springer.com/chapter/10.1007/978-3-319-39406-0_1.

Title:
Molecular Cell Biology of Apoptosis and Necroptosis in Cancer | SpringerLink
Description:
Cell death is a major mechanism to eliminate cells in which DNA is damaged, organelles are stressed, or oncogenes are overexpressed, all events that would otherwise predispose cells to oncogenic transformation. The pathways that initiate and execute cell death are...
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Keywords {🔍}

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Topics {✒️}

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Questions {❓}

Bcl-2 family proteins in breast development and cancer: could Mcl-1 targeting overcome therapeutic resistance?

Schema {🗺️}

ScholarlyArticle:
      headline:Molecular Cell Biology of Apoptosis and Necroptosis in Cancer
      pageEnd:23
      pageStart:1
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-319-39406-0.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy
         isbn:
            978-3-319-39406-0
            978-3-319-39404-6
         type:Book
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Christopher P. Dillon
            affiliation:
                  name:St. Jude Children’s Research Hospital
                  address:
                     name:Department of Immunology, St. Jude Children’s Research Hospital, Memphis, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Douglas R. Green
            affiliation:
                  name:St. Jude Children’s Research Hospital
                  address:
                     name:Department of Immunology, St. Jude Children’s Research Hospital, Memphis, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Cell death, Apoptosis, Necroptosis, RIPK3, BCL-2, Caspases, Cancer, Inflammation, Immunogenic
      description:Cell death is a major mechanism to eliminate cells in which DNA is damaged, organelles are stressed, or oncogenes are overexpressed, all events that would otherwise predispose cells to oncogenic transformation. The pathways that initiate and execute cell death are complex, genetically encoded, and subject to significant regulation. Consequently, while these pathways are often mutated in malignancy, there is considerable interest in inducing cell death in tumor cells as therapy. This chapter addresses our current understanding of molecular mechanisms contributing to two cell death pathways, apoptotic cell death and necroptosis, a regulated form of necrotic cell death. Apoptosis can be induced by a wide variety of signals, leading to protease activation that dismantles the cell. We discuss the physiological importance of each apoptosis pathway and summarize their known roles in cancer suppression and the current efforts at targeting each pathway therapeutically. The intricate mechanistic link between death receptor-mediated apoptosis and necroptosis is described, as well as the potential opportunities for utilizing necroptosis in the treatment of malignancy.
      datePublished:2016
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Book:
      name:Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy
      isbn:
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         978-3-319-39404-6
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      name:Springer International Publishing
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      name:St. Jude Children’s Research Hospital
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         name:Department of Immunology, St. Jude Children’s Research Hospital, Memphis, USA
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         name:Department of Immunology, St. Jude Children’s Research Hospital, Memphis, USA
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            address:
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      email:[email protected]
      name:Douglas R. Green
      affiliation:
            name:St. Jude Children’s Research Hospital
            address:
               name:Department of Immunology, St. Jude Children’s Research Hospital, Memphis, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
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      name:Department of Immunology, St. Jude Children’s Research Hospital, Memphis, USA
      name:Department of Immunology, St. Jude Children’s Research Hospital, Memphis, USA
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