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Title[redir]:
Caspase-2 Cleavage of BID Is a Critical Apoptotic Signal Downstream of Endoplasmic Reticulum Stress - PMC
Description:
The accumulation of misfolded proteins stresses the endoplasmic reticulum (ER) and triggers cell death through activation of the multidomain proapoptotic BCL-2 proteins BAX and BAK at the outer mitochondrial membrane. The signaling events that ...
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Keywords {🔍}
bid, caspase, stress, cells, mefs, dko, bfa, cell, fig, doi, pubmed, google, scholar, mitochondrial, cytochrome, apoptosis, apoptotic, cleavage, untreated, mitochondria, bfatreated, protein, proteins, μgml, treated, response, stressinduced, release, death, bak, inhibitor, sirna, min, incubated, extracts, bax, extract, endoplasmic, activation, activity, bim, treatment, pmc, reticulum, bhonly, resistance, recombinant, control, supernatant, isolated,
Topics {✒️}
reverse transcription-pcr-based assay triggering bax/bak-dependent cytochrome full-length v5-tagged wt caspase-8 inhibitor z-ietd-fmk pgex-2t-bcl-xl plasmid endoplasmic-reticulum-resident kinase produce recombinant gst-bcl-xl dana-farber cancer institute endoplasmic reticulum-initiated apoptosis konica srx-101a developer pancaspase inhibitor zvad-fmk cap-dependent protein translation m-110s microfluidizer processor enzyme-linked immunosorbent assay cytochrome c-releasing activity er-localized transmembrane kinase 50 μm z-vdvad-fmk express gst-bcl-xl recognize v5-tagged tbid specifically activating bax/bak pmc beta search tnf-α-cycloheximide-treated cells ire1α-mediated intron removal endogenous full-length bid er stress-induced phosphorylation mitochondrial apoptosis-inducing factor er stress-induced apoptosis v5-tagged wt bid er-golgi protein transport isopropyl-β-d-thiogalactopyranoside age-matched wild-type anti-full-length caspase-8 aβ-induced cell death liver-specific cre deletion z-vad-fmk er stress-induced death er stress-inducing agents er stress-induced protease z-vdvad-fmk z- vdvad-fmk z-ietd-cho heat shock-induced death tnf-α-cycloheximide led open-source imagej software endoplasmic reticulum ca2+ z-ietd-fmk membrane-targeted death ligand isotype-matched control antibody bd pharmingen anti-cytochrome endoplasmic reticulum stress
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