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Title[redir]:
Bcl-2 family proteins in breast development and cancer: could Mcl-1 targeting overcome therapeutic resistance? - PMC
Description:
Apoptosis, cell death executed by caspases, is essential to normal breast development and homeostasis. Pro-apoptotic and anti-apoptotic signals are tightly regulated in normal breast epithelial cells. Dysregulation of this balance is required for ...
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Keywords {π}
doi, bcl, breast, cell, cancer, google, scholar, mcl, pubmed, family, proteins, antiapoptotic, apoptosis, pmc, cancers, death, article, mammary, free, abt, cells, tumor, resistance, expression, inhibitor, involution, bax, development, bclxl, bim, members, protein, targeting, proapoptotic, pathway, activity, therapeutic, gland, apoptotic, bakbax, bhonly, overexpression, studies, tumors, targeted, signaling, figure, levels, response, transgenic,
Topics {βοΈ}
accelerates c-myc-induced tumorigenesis mmtv-c-myc transgenic mice bcl-xlfl/fl mmtv-cre c-myc dependent expression enhance bak/bax-mediated momp anti-apoptotic family members counteract anti-apoptotic members bcl-xl/bim fragment complex pre-clinical testing remains sv40 large t-antigen sequestering anti-apoptotic proteins triple-negative breast cancers estrogen-responsive elements present inhibit bak/bax-mediated apoptosis form higher-order oligomers include anti-apoptotic proteins pten-deficient tumor cells targeting bcl-2/bcl-xl/bcl sustains base-line activity 17beta-estradiol inhibits apoptosis oncogene-expressing mammary acini leukemia/lymphoma cell lines anti-apoptotic bcl-2 proteins anti-apoptotic proteins bcl-2 pmc beta search genetic bcl-xl ablation long-term estrogen deprivation small-cell lung cancer anthracene-treated transgenic mice undergo hormonally-induced growth pro-apoptotic bcl-2 protein pi3k/akt kinase pathways patient-level meta-analysis chemo-refractory tnbc samples pro-apoptotic protein bax stabilize protein-protein interactions c-myc induced [25] ubiquitin-mediated proteasomal degradation therapy-induced cell death mcl-1-expressing myeloma cells /sv40-tag transgenic mice anti-apoptotic signals cooperate bcl-2-expressing breast tumors 78-kda glucose-regulated protein rapid pregnancy-induced growth targeted high-affinity inhibitor bak-mediated mitochondrial apoptosis pro-apoptotic bcl-2 activators pre-clinical models support anti-her2 antibody
Questions {β}
- Bcl-2 family proteins in breast development and cancer: could Mcl-1 targeting overcome therapeutic resistance?
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- How much cash flow does https://scholar.google.com/scholar_lookup?journal=Mol%20Cancer&title=c-Myc%20dependent%20expression%20of%20pro-apoptotic%20Bim%20renders%20HER2-overexpressing%20breast%20cancer%20cells%20dependent%20on%20anti-apoptotic%20Mcl-1&volume=10&publication_year=2011&pmid=21899728&doi=10.1186/1476-4598-10-110& have monthly?
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- What are the total earnings of https://scholar.google.com/scholar_lookup?journal=J%20Clin%20Oncol&title=Phase%20I%20study%20of%20Navitoclax%20(ABT-263),%20a%20novel%20Bcl-2%20family%20inhibitor,%20in%20patients%20with%20small-cell%20lung%20cancer%20and%20other%20solid%20tumors&volume=29&publication_year=2011&pages=909-916&pmid=21282543&doi=10.1200/JCO.2010.31.6208&?
- What's the income of https://scholar.google.com/scholar_lookup?journal=Am%20J%20Pathol&title=Bcl-2%20protein%20expression%20and%20long-term%20survival%20in%20breast%20cancer&volume=145&publication_year=1994&pages=1191-1198&pmid=7977649&?
- http://cbioportal.org income
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- What's the financial gain of https://scholar.google.com/scholar_lookup?journal=Febs%20Lett&title=Mcl-1,%20the%20molecular%20regulation%20of%20protein%20function&volume=584&publication_year=2010&pages=2981-2989&pmid=20540941&doi=10.1016/j.febslet.2010.05.061&?
- How much does https://doi.org/10.1038/nrc3538 rake in every month?
- https://scholar.google.com/scholar_lookup?journal=Nat%20Rev%20Cancer&title=Decoding%20and%20unlocking%20the%20BCL-2%20dependency%20of%20cancer%20cells&volume=13&publication_year=2013&pages=455-465&pmid=23783119&doi=10.1038/nrc3538&'s total income per month
- How much profit is https://doi.org/10.1158/0008-5472.CAN-08-0579 making per month?
- What's the total monthly financial gain of https://scholar.google.com/scholar_lookup?journal=Cancer%20Research&title=Down-regulation%20of%20myeloid%20cell%20leukemia-1%20through%20inhibiting%20Erk/Pin%201%20pathway%20by%20sorafenib%20facilitates%20chemosensitization%20in%20breast%20cancer&volume=68&publication_year=2008&pages=6109-6117&pmid=18676833&doi=10.1158/0008-5472.CAN-08-0579&?
- What's the profit of https://doi.org/10.1073/pnas.0804821105?
- https://scholar.google.com/scholar_lookup?journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&title=mTORC1%20promotes%20survival%20through%20translational%20control%20of%20Mcl-1&volume=105&publication_year=2008&pages=10853-10858&pmid=18664580&doi=10.1073/pnas.0804821105&'s financial summary
- What are the total earnings of https://doi.org/10.1038/sj.onc.1204140?
- Get to know what's the income of https://scholar.google.com/scholar_lookup?journal=Oncogene&title=The%20involvement%20of%20PI3-K/Akt-dependent%20up-regulation%20of%20Mcl-1%20in%20the%20prevention%20of%20apoptosis%20of%20Hep3B%20cells%20by%20interlenkin-6&volume=20&publication_year=2001&pages=677-685&pmid=11314001&doi=10.1038/sj.onc.1204140&
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- What's the financial intake of https://scholar.google.com/scholar_lookup?journal=Cancer%20Lett&title=PI3K/mTOR%20dual%20inhibitor%20NVP-BEZ235%20decreases%20Mcl-1%20expression%20and%20sensitizes%20ovarian%20carcinoma%20cells%20to%20Bcl-xL-targeting%20strategies,%20provided%20that%20Bim%20expression%20is%20induced&volume=348&publication_year=2014&pages=38-49&pmid=24650799&doi=10.1016/j.canlet.2014.03.001&?
- How much revenue does https://doi.org/10.1158/2159-8290.CD-13-0315 generate?
- What's the financial intake of https://scholar.google.com/scholar_lookup?journal=Cancer%20Discovery&title=mTOR%20Inhibition%20Specifically%20Sensitizes%20Colorectal%20Cancers%20with%20KRAS%20or%20BRAF%20Mutations%20to%20BCL-2/BCL-XL%20Inhibition%20by%20Suppressing%20MCL-1&volume=4&publication_year=2014&pages=42-52&pmid=24163374&doi=10.1158/2159-8290.CD-13-0315&?
- Check the income stats for https://doi.org/10.1158/0008-5472.CAN-06-1788
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- https://scholar.google.com/scholar_lookup?journal=Cancer%20Biol%20Ther&title=Inhibition%20of%20MCL-1%20in%20breast%20cancer%20cells%20promotes%20cell%20death%20in%20vitro%20and%20in%20vivo&volume=10&publication_year=2010&pages=907-921&pmid=20855960&doi=10.4161/cbt.10.9.13273& income
- Income figures for https://doi.org/10.1182/blood-2009-07-233304
- What's the revenue for https://scholar.google.com/scholar_lookup?journal=Blood&title=Acquired%20resistance%20to%20ABT-737%20in%20lymphoma%20cells%20that%20up-regulate%20MCL-1%20and%20BFL-1&volume=115&publication_year=2010&pages=3304-3313&pmid=20197552&doi=10.1182/blood-2009-07-233304&?
- How much does https://doi.org/10.1158/0008-5472.CAN-11-4106 gross monthly?
- What's the monthly income of https://scholar.google.com/scholar_lookup?journal=Cancer%20Research&title=Mcl-1%20Phosphorylation%20Defines%20ABT-737%20Resistance%20That%20Can%20Be%20Overcome%20by%20Increased%20NOXA%20Expression%20in%20Leukemic%20B%20cells&volume=72&publication_year=2012&pages=3069-3079&pmid=22525702&doi=10.1158/0008-5472.CAN-11-4106&?
- What's the income generated by https://doi.org/10.1182/blood-2011-01-327197 each month?
- https://scholar.google.com/scholar_lookup?journal=Blood&title=Distribution%20of%20Bim%20determines%20Mcl-1%20dependence%20or%20codependence%20with%20Bcl-x(L)/Bcl-2%20in%20Mcl-1-expressing%20myeloma%20cells&volume=118&publication_year=2011&pages=1329-1339&pmid=21659544&doi=10.1182/blood-2011-01-327197&'s total income per month
- What's the profit of https://doi.org/10.1016/j.ccr.2006.10.006?
- What is the monthly revenue of https://scholar.google.com/scholar_lookup?journal=Cancer%20Cell&title=Mechanisms%20of%20apoptosis%20sensitivity%20and%20resistance%20to%20the%20BH3%20mimetic%20ABT-737%20in%20acute%20myeloid%20leukemia&volume=10&publication_year=2006&pages=375-388&pmid=17097560&doi=10.1016/j.ccr.2006.10.006&?
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- https://scholar.google.com/scholar_lookup?journal=Clin%20Cancer%20Res&title=Tipping%20the%20Noxa/Mcl-1%20balance%20overcomes%20ABT-737%20resistance%20in%20chronic%20lymphocytic%20leukemia&volume=18&publication_year=2012&pages=487-498&pmid=22128299&doi=10.1158/1078-0432.CCR-11-1440&'s revenue stream
- What's the income of https://doi.org/10.1158/1535-7163.MCT-09-0651?
- Revenue of https://scholar.google.com/scholar_lookup?journal=Mol%20Cancer%20Ther&title=Identification%20of%20expression%20signatures%20predictive%20of%20sensitivity%20to%20the%20Bcl-2%20family%20member%20inhibitor%20ABT-263%20in%20small%20cell%20lung%20carcinoma%20and%20leukemia/lymphoma%20cell%20lines&volume=9&publication_year=2010&pages=545-557&pmid=20179162&doi=10.1158/1535-7163.MCT-09-0651&
- Financial intake of https://doi.org/10.1016/j.pharmthera.2014.08.003
- What is the monthly revenue of https://scholar.google.com/scholar_lookup?journal=Pharmacol%20Ther&title=Small%20molecule%20Mcl-1%20inhibitors%20for%20the%20treatment%20of%20cancer&publication_year=2014&pmid=25172548&doi=10.1016/j.pharmthera.2014.08.003&?
- How much money does https://doi.org/10.1074/jbc.M111.334532 generate?
- How much cash flow does https://scholar.google.com/scholar_lookup?journal=Journal%20of%20Biological%20Chemistry&title=Discovery%20of%20marinopyrrole%20A%20(maritoclax)%20as%20a%20selective%20Mcl-1%20antagonist%20that%20overcomes%20ABT-737%20resistance%20by%20binding%20to%20and%20targeting%20Mcl-1%20for%20proteasomal%20degradation&volume=287&publication_year=2012&pages=10224-10235&pmid=22311987&doi=10.1074/jbc.M111.334532& have monthly?
- What's https://doi.org/10.1158/1535-7163.MCT-12-0767's gross income?
- What's the income of https://scholar.google.com/scholar_lookup?journal=Mol%20Cancer%20Ther&title=A%20novel%20small-molecule%20inhibitor%20of%20mcl-1%20blocks%20pancreatic%20cancer%20growth%20in%20vitro%20and%20in%20vivo&volume=13&publication_year=2014&pages=565-575&pmid=24019208&doi=10.1158/1535-7163.MCT-12-0767&?
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- Income figures for https://www.nlm.nih.gov/web_policies.html
- How much does https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office generate monthly?
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