
NCBI . NLM . NIH . GOV {
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Title[redir]:
Triggering necroptosis in cisplatin and IAP antagonist-resistant ovarian carcinoma - PMC
Description:
Ovarian cancer patients are typically treated with carboplatin and paclitaxel, but suffer a high rate of relapse with recalcitrant disease. This challenge has fostered the development of novel approaches to treatment, including antagonists of the ...
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Keywords {🔍}
ripk, cell, cells, cancer, death, ovarian, figure, expression, treatment, apoptosis, tnfα, doi, necroptosis, ovcar, pubmed, google, scholar, protein, inhibitor, lines, iap, tumor, kinase, iapa, control, usa, caspase, complex, signaling, shown, serous, evaluated, mlkl, pmc, hey, agents, ciap, proteins, fadd, necrostatin, izinduced, disease, formation, required, pathway, loss, supplementary, analysis, nlm, article,
Topics {✒️}
receptor-interacting serine–threonine kinase-1 receptor-interacting serine–threonine kinase-3 nuclear factor-κ-light-chain-enhancer z-val-ala-dl-asp-fmkiz ring-type zinc-finger domain z-val-ala-dl-asp-fmk tumor necrosis factor-α tnf-induced nf-kappab signal tnfα receptor-mediated signaling pancaspase inhibitor zvad-fmk canonical nf-κb pathway poly-adp ribose polymerase goat anti-rabbit igg mouse anti-rabbit igg goat anti-mouse igg pmc beta search high cisplatin resistance light-chain-specific cellular death pathway plv ripk3-mcherry plasmid apoptosis z-vad-fmk promotes iz-induced death wild-type kinase small-cell lung cancers death-inducing ripk3 substrate specific triple-negative breast serous ovarian cancer iz-sensitive cell lines +z-induced cell death tnf-alpha-independent mechanism c-iap1/2 leads apoptosis-resistant cell lines cell-bound crystal violet iz-induced cell death tnfr2-traf signaling complex block iz-induced death ovarian tumor cells structure-activity relationship analysis serous ovarian cancers death-resistant hey cells kinase dead version kinase dead mutant death-inducible ovcar3 cells full-length mcherry x-linked inhibitor tumor protein p53 cellular inhibitor epithelial cancers derived death domain protein necroptosis-resistant hey cells
Questions {❓}
- Killing a cancer: what are the alternatives?
- The genetic complexity of common cancers and the promise of personalized medicine: is there any hope?
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