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Content Management System {📝}

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Custom-built

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What is the average monthly size of ncbi.nlm.nih.gov audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


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Keywords {🔍}

doi, bcl, proteins, pubmed, google, scholar, bax, family, mitochondrial, apoptosis, cell, bak, antiapoptotic, bhonly, momp, protein, free, pmc, function, article, bim, direct, promote, bclxl, activation, groove, autophagy, mcl, domain, figure, proapoptotic, death, binding, bid, fission, biol, beclin, omm, mol, membrane, interactions, cells, mitochondria, puma, complex, release, bad, stress, directly, mice,

Topics {✒️}

anti-cd95/fas-induced liver injury immunoglobulin heavy-chain locus sarco/endoplasmic reticulum ca2+-atpase glucose-driven mitochondrial respiration pmc beta search bcl-xl/bax chimeras identified n-terminal unstructured domain bacterial/viral/ fungal infections opa1-dependent cristae remodeling opa1-mediated cristae opening van delft mf gene constitutively hyper-expressed major side-chain rearrangements bcl-2-related ovarian killer conserved hydrophobic residues/sites displays single-agent effectiveness dap-kinase promotes autophagy dna end-joining protein bim-mediated bak/bax activation prevent bax/bak-dependent apoptosis direct activator/sensitizer/derepressor bh3 double-layered membrane structure bak/bax-dependent apoptosis proceeds del gaizo moore α1-α2 unstructured loop free bcl-xl ectopic bcl-xl expression promote free diffusion putative full-length bh3 inducing bcl-xl-regulated apoptosis membrane-targeted death ligand anti-apoptotic bcl-2 proteins c-terminal tm region supplementary materials included bcl-2-related gene a1 jnk1-dependent bcl-2 phosphorylation death signal-induced localization free bax structure helix homo-oligomerization domain eμ-bcl-2/c-myc outer mitochondrial membrane bak-induced mitochondrial fission growth factors inhibit martins de brito bh3 peptide-bound states beclin-1·hvps34 axis represents chronic lymphocytic leukemia bcl-xl bc groove healthy primary cells bak/bax-dependent manner

Questions {❓}

• Cell death: what can we learn from flies?
• How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?
• This represents several major challenges: How do BAK and BAX specifically disrupt the OMM?
• What other roles will be found for the BCL-2 family, as additional binding partners are discovered and interrogated?

Social Networks {👍}(6)

• https://twitter.com/ncbi
• https://www.facebook.com/ncbi.nlm
• https://www.linkedin.com/company/ncbinlm
• https://twitter.com/nlm_nih
• https://www.facebook.com/nationallibraryofmedicine
• https://www.youtube.com/user/NLMNIH

External Links {🔗}(190)

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• What's the financial intake of https://scholar.google.com/scholar_lookup?journal=Apoptosis&title=Embedded%20together:%20the%20life%20and%20death%20consequences%20of%20interaction%20of%20the%20Bcl-2%20family%20with%20membranes&author=B%20Leber&author=J%20Lin&author=DW%20Andrews&volume=12&publication_year=2007&pages=897-911&pmid=17453159&doi=10.1007/s10495-007-0746-4&?
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• What is the monthly revenue of https://scholar.google.com/scholar_lookup?journal=Nat.%20Rev.%20Cancer&title=Diagnosing%20and%20exploiting%20cancer's%20addiction%20to%20blocks%20in%20apoptosis&author=AG%20Letai&volume=8&publication_year=2008&pages=121-132&pmid=18202696&doi=10.1038/nrc2297&?
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• How much cash flow does https://scholar.google.com/scholar_lookup?journal=Autophagy&title=BH3-only%20proteins%20and%20BH3%20mimetics%20induce%20autophagy%20by%20competitively%20disrupting%20the%20interaction%20between%20Beclin%201%20and%20Bcl-2/Bcl-X(L)&author=MC%20Maiuri&author=A%20Criollo&author=E%20Tasdemir&author=JM%20Vicencio&author=N%20Tajeddine&volume=3&publication_year=2007a&pages=374-376&pmid=17438366&doi=10.4161/auto.4237& have monthly?
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• See how much https://doi.org/10.1074/jbc.275.21.16202 makes per month
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• Check the income stats for https://scholar.google.com/scholar_lookup?journal=J.%20Cell%20Biol&title=The%20role%20of%20BH3-only%20protein%20Bim%20extends%20beyond%20inhibiting%20Bcl-2-like%20prosurvival%20proteins&author=D%20Merino&author=M%20Giam&author=PD%20Hughes&author=OM%20Siggs&author=K%20Heger&volume=186&publication_year=2009&pages=355-362&pmid=19651893&doi=10.1083/jcb.200905153&
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• See how much https://scholar.google.com/scholar_lookup?journal=Mol.%20Cell&title=p53%20has%20a%20direct%20apoptogenic%20role%20at%20the%20mitochondria&author=M%20Mihara&author=S%20Erster&author=A%20Zaika&author=O%20Petrenko&author=T%20Chittenden&volume=11&publication_year=2003&pages=577-590&pmid=12667443&doi=10.1016/s1097-2765(03)00050-9& makes per month
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• Profit of https://doi.org/10.1073/pnas.0408352102
• https://scholar.google.com/scholar_lookup?journal=Proc.%20Natl.%20Acad.%20Sci.%20USA&title=Proapoptotic%20BAX%20and%20BAK%20regulate%20the%20type%201%20inositol%20trisphosphate%20receptor%20and%20calcium%20leak%20from%20the%20endoplasmic%20reticulum&author=SA%20Oakes&author=L%20Scorrano&author=JT%20Opferman&author=MC%20Bassik&author=M%20Nishino&volume=102&publication_year=2005&pages=105-110&pmid=15613488&doi=10.1073/pnas.0408352102&'s financial summary
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• How much money does https://scholar.google.com/scholar_lookup?journal=J.%20Biol.%20Chem&title=Crystal%20structure%20of%20the%20Bcl-XLBeclin%201%20peptide%20complex:%20Beclin%201%20is%20a%20novel%20BH3-only%20protein&author=A%20Oberstein&author=PD%20Jeffrey&author=Y%20Shi&volume=282&publication_year=2007&pages=13123-13132&pmid=17337444&doi=10.1074/jbc.M700492200& make?
• How much profit does https://doi.org/10.1038/nature03579 generate?
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• What's https://doi.org/10.1126/science.1106114's gross income?
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• How much does https://scholar.google.com/scholar_lookup?journal=Proc.%20Natl.%20Acad.%20Sci.%20USA&title=The%20multidomain%20proapoptotic%20molecules%20Bax%20and%20Bak%20are%20directly%20activated%20by%20heat&author=LJ%20Pagliari&author=T%20Kuwana&author=C%20Bonzon&author=DD%20Newmeyer&author=S%20Tu&volume=102&publication_year=2005&pages=17975-17980&pmid=16330765&doi=10.1073/pnas.0506712102& make?
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• How much does https://scholar.google.com/scholar_lookup?journal=Mol.%20Cell.%20Biol&title=Inhibiting%20the%20mitochondrial%20fission%20machinery%20does%20not%20prevent%20Bax/Bak-dependent%20apoptosis&author=PA%20Parone&author=DI%20James&author=S%20Da%20Cruz&author=Y%20Mattenberger&author=O%20Donz%C3%A9&volume=26&publication_year=2006&pages=7397-7408&pmid=17015472&doi=10.1128/MCB.02282-05& pull in monthly?
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• What are the total earnings of https://scholar.google.com/scholar_lookup?journal=J.%20Biol.%20Chem&title=Role%20of%20JNK1-dependent%20Bcl-2%20phosphorylation%20in%20ceramide-induced%20macroautophagy&author=S%20Pattingre&author=C%20Bauvy&author=S%20Carpentier&author=T%20Levade&author=B%20Levine&volume=284&publication_year=2009&pages=2719-2728&pmid=19029119&doi=10.1074/jbc.M805920200&?
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• What's https://doi.org/10.1038/nrm2153's gross income?
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• How much does https://scholar.google.com/scholar_lookup?journal=Nature&title=Essential%20role%20for%20Nix%20in%20autophagic%20maturation%20of%20erythroid%20cells&author=H%20Sandoval&author=P%20Thiagarajan&author=SK%20Dasgupta&author=A%20Schumacher&author=JT%20Prchal&volume=454&publication_year=2008&pages=232-235&pmid=18454133&doi=10.1038/nature07006& rake in every month?
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• https://scholar.google.com/scholar_lookup?journal=Science&title=BAX%20and%20BAK%20regulation%20of%20endoplasmic%20reticulum%20Ca2+:%20a%20control%20point%20for%20apoptosis&author=L%20Scorrano&author=SA%20Oakes&author=JT%20Opferman&author=EH%20Cheng&author=MD%20Sorcinelli&volume=300&publication_year=2003&pages=135-139&pmid=12624178&doi=10.1126/science.1081208&'s revenue stream
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• Income figures for https://scholar.google.com/scholar_lookup?journal=Nature&title=Novel%20primitive%20lymphoid%20tumours%20induced%20in%20transgenic%20mice%20by%20cooperation%20between%20myc%20and%20bcl-2&author=A%20Strasser&author=AW%20Harris&author=ML%20Bath&author=S%20Cory&volume=348&publication_year=1990&pages=331-333&pmid=2250704&doi=10.1038/348331a0&
• What is the monthly revenue of https://doi.org/10.1038/ncb1630?
• How much revenue does https://scholar.google.com/scholar_lookup?journal=Nat.%20Cell%20Biol&title=Correlated%20three-dimensional%20light%20and%20electron%20microscopy%20reveals%20transformation%20of%20mitochondria%20during%20apoptosis&author=MG%20Sun&author=J%20Williams&author=C%20Munoz-Pinedo&author=G%20Perkins&author=JM%20Brown&volume=9&publication_year=2007&pages=1057-1065&pmid=17721514&doi=10.1038/ncb1630& generate?
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• See how much https://scholar.google.com/scholar_lookup?journal=J.%20Cell%20Biol&title=Mitochondrial%20permeabilization%20relies%20on%20BH3%20ligands%20engaging%20multiple%20prosurvival%20Bcl-2%20relatives,%20not%20Bak&author=RT%20Uren&author=G%20Dewson&author=L%20Chen&author=SC%20Coyne&author=DC%20Huang&volume=177&publication_year=2007&pages=277-287&pmid=17452531&doi=10.1083/jcb.200606065& makes per month
• What's https://doi.org/10.1016/j.ccr.2006.08.027's gross income?
• How much does https://scholar.google.com/scholar_lookup?journal=Cancer%20Cell&title=The%20BH3%20mimetic%20ABT-737%20targets%20selective%20Bcl-2%20proteins%20and%20efficiently%20induces%20apoptosis%20via%20Bak/Bax%20if%20Mcl-1%20is%20neutralized&author=MF%20van%20Delft&author=AH%20Wei&author=KD%20Mason&author=CJ%20Vandenberg&author=L%20Chen&volume=10&publication_year=2006&pages=389-399&pmid=17097561&doi=10.1016/j.ccr.2006.08.027& pull in?
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