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DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Schema
  9. Social Networks
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. Hosting Providers
  14. CDN Services

We began analyzing https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-025-02236-7, but it redirected us to https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-025-02236-7. The analysis below is for the second page.

Title[redir]:
lncRNAs: the unexpected link between protein synthesis and cancer adaptation | Molecular Cancer | Full Text
Description:
Cancer progression relies on the ability of cells to adapt to challenging environments overcoming stresses and growth constraints. Such adaptation is a multifactorial process that depends on the rapid reorganization of many basic cellular mechanisms. Protein synthesis is often dysregulated in cancer, and translational reprogramming is emerging as a driving force of cancer adaptive plasticity. Long non-coding RNAs (lncRNAs) represent the main product of genome transcription. They outnumber mRNAs by an order of magnitude and their expression is regulated in an extremely specific manner depending on context, space and time. This heterogeneity is functional and allows lncRNAs to act as context-specific, fine-tuning controllers of gene expression. Multiple recent evidence underlines how, besides their consolidated role in transcription, lncRNAs are major players in translation control. Their capacity to establish multiple and highly dynamic interactions with proteins and other transcripts makes these molecules able to play a central role across all phases of protein synthesis. Even if through a myriad of different mechanisms, the action of these transcripts is dual. On one hand, by modulating the overall translation speed, lncRNAs participate in the process of metabolic adaptation of cancer cells under stress conditions. On the other hand, by prioritizing the synthesis of specific transcripts they help cancer cells to maintain high levels of essential oncogenes. In this review, we aim to discuss the most relevant evidence regarding the involvement of lncRNAs in translation regulation and to discuss how this specific function may affect cancer plasticity and resistance to stress. We also expect to provide one of the first collective perspectives on the way these transcripts modulate gene expression beyond transcription.

Matching Content Categories {📚}

  • Health & Fitness
  • Education
  • Science

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🚀 Good Traffic: 50k - 100k visitors per month


Based on our best estimate, this website will receive around 50,019 visitors per month in the current month.
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How Does Doi.org Make Money? {💸}

We find it hard to spot revenue streams.

Not all websites are made for profit; some exist to inform or educate users. Or any other reason why people make websites. And this might be the case. Doi.org might have a hidden revenue stream, but it's not something we can detect.

Keywords {🔍}

pubmed, article, google, scholar, cas, cancer, translation, lncrnas, central, cell, mrna, protein, stress, lncrna, noncoding, ribosome, synthesis, rna, regulation, initiation, complex, long, mrnas, nat, biol, expression, specific, splicing, cells, response, mol, zhang, binding, wang, function, liu, factors, promotes, translational, assembly, rnas, transcripts, proteins, formation, ribosomes, mechanisms, gene, control, molecules, functions,

Topics {✒️}

additional information publisher tgf-beta/smad2/3 signaling pathway ankhd1/linc00346/znf655 feedback loop myc/eif4a-survival axis improves functional lncrna/mirna/mrna axes springer nature cigarette smoking-induced inflammation low-energy-cost adaptation process state privacy rights introduction figures sharing complex eef1a-gtp-trna binds wnt/beta-catenin pathway rna-mediated feedback control pik3ca/pi3k/akt/mtor signaling [63] context-specific post-transcriptional modifications rna-poli transcribes rrnas foxd1-as1 sponges mir-466 biomolecular condensates potent anti-tumour response tm4sf1-as1 inhibits apoptosis smn-primed ribosomes modulate promotes epithelial-specific splicing promotes cap-independent translation strong antigen-specific cd8 + related rho/rock signaling staufen1-mediated mrna decay triggering nonsense-mediated decay original author data availability splicing-specific chromatin signature double-stranded rna formed study phase-separated condensates pro-apoptotic gene pycard suppressing nedd4l-mediated degradation stress-responsive mapk pathway intracellular cholesterol availability 43s pre-initiation complex phase-separating protein caprin1 e-cadherin mrna slowing cap-independent translation sequences histone methyltransferase suv4-20h2 pd-l1 gene pi3k/akt/mtor pathway feed-forward translational coactivator promoting rna-poli processivity ribosome biogenesis-cancer connection pd-l1-lnc stress-modulated ribosome shunt

Schema {🗺️}

WebPage:
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         headline:lncRNAs: the unexpected link between protein synthesis and cancer adaptation
         description:Cancer progression relies on the ability of cells to adapt to challenging environments overcoming stresses and growth constraints. Such adaptation is a multifactorial process that depends on the rapid reorganization of many basic cellular mechanisms. Protein synthesis is often dysregulated in cancer, and translational reprogramming is emerging as a driving force of cancer adaptive plasticity. Long non-coding RNAs (lncRNAs) represent the main product of genome transcription. They outnumber mRNAs by an order of magnitude and their expression is regulated in an extremely specific manner depending on context, space and time. This heterogeneity is functional and allows lncRNAs to act as context-specific, fine-tuning controllers of gene expression. Multiple recent evidence underlines how, besides their consolidated role in transcription, lncRNAs are major players in translation control. Their capacity to establish multiple and highly dynamic interactions with proteins and other transcripts makes these molecules able to play a central role across all phases of protein synthesis. Even if through a myriad of different mechanisms, the action of these transcripts is dual. On one hand, by modulating the overall translation speed, lncRNAs participate in the process of metabolic adaptation of cancer cells under stress conditions. On the other hand, by prioritizing the synthesis of specific transcripts they help cancer cells to maintain high levels of essential oncogenes. In this review, we aim to discuss the most relevant evidence regarding the involvement of lncRNAs in translation regulation and to discuss how this specific function may affect cancer plasticity and resistance to stress. We also expect to provide one of the first collective perspectives on the way these transcripts modulate gene expression beyond transcription.
         datePublished:2025-01-31T00:00:00Z
         dateModified:2025-01-31T00:00:00Z
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            Protein synthesis
            Cancer plasticity
            Ribosomes
            Biomolecular condensates
            Cancer Research
            Oncology
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      headline:lncRNAs: the unexpected link between protein synthesis and cancer adaptation
      description:Cancer progression relies on the ability of cells to adapt to challenging environments overcoming stresses and growth constraints. Such adaptation is a multifactorial process that depends on the rapid reorganization of many basic cellular mechanisms. Protein synthesis is often dysregulated in cancer, and translational reprogramming is emerging as a driving force of cancer adaptive plasticity. Long non-coding RNAs (lncRNAs) represent the main product of genome transcription. They outnumber mRNAs by an order of magnitude and their expression is regulated in an extremely specific manner depending on context, space and time. This heterogeneity is functional and allows lncRNAs to act as context-specific, fine-tuning controllers of gene expression. Multiple recent evidence underlines how, besides their consolidated role in transcription, lncRNAs are major players in translation control. Their capacity to establish multiple and highly dynamic interactions with proteins and other transcripts makes these molecules able to play a central role across all phases of protein synthesis. Even if through a myriad of different mechanisms, the action of these transcripts is dual. On one hand, by modulating the overall translation speed, lncRNAs participate in the process of metabolic adaptation of cancer cells under stress conditions. On the other hand, by prioritizing the synthesis of specific transcripts they help cancer cells to maintain high levels of essential oncogenes. In this review, we aim to discuss the most relevant evidence regarding the involvement of lncRNAs in translation regulation and to discuss how this specific function may affect cancer plasticity and resistance to stress. We also expect to provide one of the first collective perspectives on the way these transcripts modulate gene expression beyond transcription.
      datePublished:2025-01-31T00:00:00Z
      dateModified:2025-01-31T00:00:00Z
      pageStart:1
      pageEnd:15
      license:http://creativecommons.org/licenses/by-nc-nd/4.0/
      sameAs:https://doi.org/10.1186/s12943-025-02236-7
      keywords:
         lncRNAs
         Protein synthesis
         Cancer plasticity
         Ribosomes
         Biomolecular condensates
         Cancer Research
         Oncology
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            name:Mila Gugnoni
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                  name:Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia
                  address:
                     name:Laboratory of Translational Research, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Manoj Kumar Kashyap
            affiliation:
                  name:Amity University Haryana, Panchgaon (Manesar)
                  address:
                     name:Molecular Oncology Laboratory, Amity Stem Cell Institute, Amity Medical School, Amity University Haryana, Panchgaon (Manesar), Gurugram, India
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Kishore K. Wary
            affiliation:
                  name:University of Illinois
                  address:
                     name:Department of Pharmacology and Regenerative Medicine, University of Illinois, Chicago, USA
                     type:PostalAddress
                  type:Organization
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            type:Person
            name:Alessia Ciarrocchi
            affiliation:
                  name:Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia
                  address:
                     name:Laboratory of Translational Research, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy
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         type:PostalAddress
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      address:
         name:Molecular Oncology Laboratory, Amity Stem Cell Institute, Amity Medical School, Amity University Haryana, Panchgaon (Manesar), Gurugram, India
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      affiliation:
            name:Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia
            address:
               name:Laboratory of Translational Research, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy
               type:PostalAddress
            type:Organization
      name:Manoj Kumar Kashyap
      affiliation:
            name:Amity University Haryana, Panchgaon (Manesar)
            address:
               name:Molecular Oncology Laboratory, Amity Stem Cell Institute, Amity Medical School, Amity University Haryana, Panchgaon (Manesar), Gurugram, India
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Kishore K. Wary
      affiliation:
            name:University of Illinois
            address:
               name:Department of Pharmacology and Regenerative Medicine, University of Illinois, Chicago, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Alessia Ciarrocchi
      affiliation:
            name:Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia
            address:
               name:Laboratory of Translational Research, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Laboratory of Translational Research, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy
      name:Molecular Oncology Laboratory, Amity Stem Cell Institute, Amity Medical School, Amity University Haryana, Panchgaon (Manesar), Gurugram, India
      name:Department of Pharmacology and Regenerative Medicine, University of Illinois, Chicago, USA
      name:Laboratory of Translational Research, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy

Social Networks {👍}(2)

External Links {🔗}(857)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Prism.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {📦}

  • Crossref

4.2s.