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Title[redir]:
Dysregulation of Ribosome Biogenesis and Translational Capacity Is Associated with Tumor Progression of Human Breast Cancer Cells - PMC
Description:
Protein synthesis is a fundamental cell process and ribosomes - particularly through the ribosomal RNA that display ribozyme activity - are the main effectors of this process. Ribosome biogenesis is a very complex process involving transcriptional ...
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Keywords {🔍}
cells, doi, rrna, cell, ribosome, ribosomal, pubmed, google, scholar, methylation, analysis, biogenesis, cancer, protein, proteins, rna, activity, control, nucleoli, aggressive, vector, translational, lines, processing, human, data, prerrna, performed, method, synthesis, sites, results, tumor, translation, rate, ribosomes, luciferase, pmc, breast, figure, line, signal, cytoplasmic, reduced, arl, higher, article, determine, show, nucleolar,
Topics {✒️}
methionine-free cysteine-free dmem di-aminido-phenyl-indol ferre-d'amare ar r218-5′-ctaaggaagtcgggguagcggttgccaagaggttc-3′ r218-5′-gaacctcttggcaaccgcaccccgacttccttag-3′ pmc beta search bi-cistronic vector strategy m-mlv reverse transcriptase wild-type aga codon ultra-structural functional organisation mapping 2′-o-methyl groups post-transcriptional steps synchronized x-linked dyskeratosis congenita post-transcriptional processing occurs nuclear pre-rrna intermediates enhanced post-transcriptional methylation 43s pre-rrna involves initial pre-45s rrna post-transcriptional rrna processing post-transcriptional chemical modifications human breast cancer ires-dependent translational ability nuclear 45s pre-rrna cap-dependent scanning mechanism nat rev cancer pre-rrna processing occurs specific 2d-gel system proto-oncogene c-myc pre-rrna processing pathway ultra-structural organisation initiate cap-independent translation [3h]methyl-methionine incorporation license information pmcid ires-translation initiation plays post mitochondrial fraction ultra-structural organization breast cancer cells le quesne jp pre-rrna 45s show rt-pcr mapping method amino acid misincorporation wild type vector caused larger tumors mass spectrom rev publisher site pdf invasive cancer cells adp ribosylation factor enhanced aggressivity acquire post-transcriptional processing cell lines displayed enhanced tumor aggressivity
Questions {❓}
- Does the ribosome translate cancer?
- For labeling, 50 pmoles of each probe were incubated with 50 pmoles of [?
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