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Keywords {🔍}

translation, eife, fig, cells, mrnas, eifd, suppl, resistant, doi, pubmed, google, scholar, pmc, data, article, free, reporter, binding, reporters, ebpa, control, mrna, cell, cap, inhibition, rna, utr, expression, initiation, min, element, cdknb, rpp, utrs, functional, capbinding, luciferase, performed, rluc, protein, mtorc, activity, supplementary, proteins, resistance, hbb, translated, ribosome, incubated, transfected,

Topics {✒️}

4e-bp-4a overexpression phenocopies phenocopy 4e-bp-4a overexpression author contributions 4e-bp-4a strongly reduces 4e-bp-4a overexpression caused cells expressing 4e-bp-4a yielding 4e-bp-4a∆tos cells expressing 4e-bp1-4a 4e-bp-induced translation inhibition full-length 4e-bp1-4a 4e-bp-4a expression condition rnase- dnase-free water code availability competing interests turbo dna-free kit q-rt-pcr primer pairs 4e-bp-4a overexpression translation efficiency 4e-bp1-4a/ peer review file phenol-chloroform isoamyl alcohol mason-pfizer monkey virus methods cell lines eif4f-mediated ribosomal attachment 4e-bp-4a expression 4e-bp-4a∆tos pmc beta search 4e-bp1-4a expression targeted crispr-cas9 screen targeted crispr-cas9 screens footnotes publisher high cap-affinity state data availability statements data availability statement 4e-bp1-4a construct mtorc1-mediated cell proliferation negative-control hbb-rluc reporter crispr/sgrna-mediated knockout hypothesized 4e-bp-4a mutated 4e-bp-4a denrmcts1-dependent translation including m6a-dependent initiation15 ecdysone-dependent neuronal remodeling a-dependent mrna degradation acid-phenol chloroform extraction bi-cistronic reporter suitable promotes cap-independent translation cap-binding-mediated functions peer review altered rrna 2′-o-methylation alternate cap-binding protein

Questions {❓}

• How do tumours adapt to nutrient stress?
• We asked what these two regions have in common?
• What causes some, but not all, mRNAs to be translated in an eIF3d-dependent manner?
• What causes this selective binding of eIF3d to some mRNAs?

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