
NCBI . NLM . NIH . GOV {
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Title[redir]:
mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism - PMC
Description:
Energetic stress compels cells to evolve adaptive mechanisms to adjust their metabolism. Inhibition of mTOR kinase complex 1 (mTORC1) is essential for cell survival during glucose starvation. How mTORC1 controls cell viability during glucose ...
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Keywords {🔍}
cells, ebp, glucose, cell, doi, fig, starvation, pubmed, google, scholar, data, control, acc, synthesis, acid, levels, pmc, cancer, protein, fatty, article, free, expression, mtorc, hek, mice, tumor, medium, nadph, acaca, deprivation, tumors, death, translation, human, survival, grown, shebp, starved, lines, glioma, metabolic, analyzed, analysis, measured, activity, mefs, deficient, inhibition, stress,
Topics {✒️}
anti-phospho-s6 ribosomal protein mice received 10 mg/kg/day anti-phospho-acetyl-coa carboxylase 4e-bp-dependent translational regulation phase methanol–water–chloroform extraction66 gsh-glo assay kit kitz-pmc twinning program competing interests venor®gem classic kit nih 3t3 k-rasv12 mtorc1-4ebp1/2 axis provokes peer review file stably expressing k-rasv12 nad/nadh-glo™ kit doxycycline-inducible shrna system grna-dcas9-krab gfp mixture ice/dry ice mtorc1-4ebp1/2-mediated translational repression mtorc1 activators raga/b14 pmc beta search intra-tumoral metabolic zonation footnotes publisher introduction glucose hypoxia-controlled cap-dependent evaluated pro-tumorigenic functions serum-free media supplemented formalin-fixed paraffin-embedded amp-activated protein kinase failed mtorc1-dependent balancing translational inhibitor 4e-bp1 dual mtorc1/mtorc2 inhibitor ben-gurion university facility sds-page 4ebp1/2-mediated translational reprogramming glucose-free medium compared kaplan-meier survival estimates glucose-free yp media exert pro-tumorigenic functions eif4e-promoted acaca translation glucose-free yp medium stress-responsive metabolic switches methanol-water-chloroform extraction atp-consuming cellular process48 including n-acetyl cysteine license information pmcid general pro-survival function peer review pten-driven prostate cancer anti-rabbit igg fatty acid oxidation
Questions {❓}
- How does mTOR sense glucose starvation?
- Why are tumour blood vessels abnormal and why is it important to know?
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