
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Modular regulatory principles of large non–coding RNAs - PMC
Description:
It is clear that RNA has a diverse set of functions and is more than just a messenger between gene and protein. The mammalian genome is extensively transcribed, giving rise to thousands of non–coding transcripts. Whether all of these transcripts are ...
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Keywords {🔍}
doi, rna, google, scholar, pubmed, pmc, article, free, ncrnas, noncoding, large, nature, genes, ncrna, function, cell, gene, protein, rnas, interactions, functional, chromatin, transcripts, regions, expression, regulatory, genome, proteins, science, dna, xist, transcription, domains, complexes, coding, fig, human, lincrnas, transcriptional, genomic, neighbouring, modular, small, potential, long, proteincoding, identified, specific, model, regulation,
Topics {✒️}
dna–rna hybridization-based interactions conserved multi-exonic structure pmc beta search cell type-specific transcriptomes intrinsic cis-regulatory capacity neuronal activity-regulated enhancers k4–k36 chromatin signature criteria supports trans-regulation form base-pair interactions large-scale transcriptional activity small-peptide coding gene chromatin-state maps revealed protein-coding gene requires cell-type specific analysis localizing chromatin-regulatory complexes trna–mrna anticodon recognition5 rna–rna regulatory interactions form rna–rna interactions exact rna-binding proteins transcription-factor-binding landscape large protein-domain databases52 neighbouring protein-coding genes21 primary microrna precursor [google scholar] 6 unique cis-regulatory capability overlapping protein-coding genes distinct protein-interaction domains �k4–k36’ signature44 lineage-committed cells termed chromatin signatures k4–k36 domains rna maps reveal modular rna code higher-order structure trends biochem sci long noncoding rna evf-2 noncoding rna form triplex structures exquisite cell-type prevents nuclear accumulation13 investigate transcriptional activity unique rna structures noncoding rnas finds long noncoding rnas global perturbation studies cis-regulation requires achieve regulatory specificity specific protein interactions26 break coding potential determining coding potential
Questions {❓}
- A ceRNA hypothesis: the Rosetta stone of a hidden RNA language?
- Functionality or transcriptional noise?
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