We are analyzing https://link.springer.com/article/10.1186/s12929-024-01047-0.

Title:
Beyond traditional translation: ncRNA derived peptides as modulators of tumor behaviors | Journal of Biomedical Science
Description:
Within the intricate tapestry of molecular research, noncoding RNAs (ncRNAs) were historically overshadowed by a pervasive presumption of their inability to encode proteins or peptides. However, groundbreaking revelations have challenged this notion, unveiling select ncRNAs that surprisingly encode peptides specifically those nearing a succinct 100 amino acids. At the forefront of this epiphany stand lncRNAs and circRNAs, distinctively characterized by their embedded small open reading frames (sORFs). Increasing evidence has revealed different functions and mechanisms of peptides/proteins encoded by ncRNAs in cancer, including promotion or inhibition of cancer cell proliferation, cellular metabolism (glucose metabolism and lipid metabolism), and promotion or concerted metastasis of cancer cells. The discoveries not only accentuate the depth of ncRNA functionality but also open novel avenues for oncological research and therapeutic innovations. The main difficulties in the study of these ncRNA-derived peptides hinge crucially on precise peptide detection and sORFs identification. Here, we illuminate cutting-edge methodologies, essential instrumentation, and dedicated databases tailored for unearthing sORFs and peptides. In addition, we also conclude the potential of clinical applications in cancer therapy.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,542,081 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We don't see any clear sign of profit-making.

Not all websites focus on profit; some are designed to educate, connect people, or share useful tools. People create websites for numerous reasons. And this could be one such example. Link.springer.com might be making money, but it's not detectable how they're doing it.

Keywords {🔍}

pubmed, article, google, scholar, cas, cancer, central, peptides, cell, wang, zhang, rnas, translation, noncoding, peptide, cells, rna, circular, tumor, encoded, chen, liu, human, yang, expression, zhou, metastasis, mol, proliferation, protein, small, pathway, ncrna, lncrna, open, ncrnas, ribosome, promotes, long, biol, sorfs, analysis, research, functions, potential, res, sci, zhao, role, functional,

Topics {✒️}

identify short-open-reading-frame-encoded peptides wnt/β-catenin signaling pathway wnt/beta-catenin signaling pathway inhibits pi3k/akt/nfjb pathway par-acylated parp1-dna complex lncrna-encoded pep-ap attenuates linc00961-encoded spar polypeptide encode cancer-suppressive peptides/proteins restricts lactate-pyruvate conversion parp/atr/cdk4/6 inhibitors sendai virus di-rnas article download pdf wnt/ β-catenin pathway wnt/β-catenin pathway lncrna afap1-as1 promotes illuminate cutting-edge methodologies myocardial ischemia-reperfusion injury framed k-mer features wnt/beta-catenin pathway smorf-encoded bioactive polypeptides circ-eif6 encodes eif6-224aa huh7 ribo-seq dataset peptide called coro1c-47aa open reading frame highly base-paired rod pi3k/akt/nfjb pathway open reading frames targetable tumor-specific antigens cell-type specific features tumor-specific immune response inhibit c-myc ubiquitin encode plant-related peptides inhibiting ereg/egfr signaling cancer-related micropeptides encoded rho/rac signaling pathway tissue-specific circular rnas apoptosis-related protein bax age-dependent neural accumulation testis-determining gene sry full access pri-mirna-31 suppresses autoimmunity clip6-ova complex prompted promoting mllt4-as1 transcription tumor-suppressor microprotein encoded b16/ova mouse model exert antitumor effects downstream jak/stat pathway crispr-based genetic screening acute myeloid leukemia graft-versus-host disease

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Beyond traditional translation: ncRNA derived peptides as modulators of tumor behaviors
         description:Within the intricate tapestry of molecular research, noncoding RNAs (ncRNAs) were historically overshadowed by a pervasive presumption of their inability to encode proteins or peptides. However, groundbreaking revelations have challenged this notion, unveiling select ncRNAs that surprisingly encode peptides specifically those nearing a succinct 100 amino acids. At the forefront of this epiphany stand lncRNAs and circRNAs, distinctively characterized by their embedded small open reading frames (sORFs). Increasing evidence has revealed different functions and mechanisms of peptides/proteins encoded by ncRNAs in cancer, including promotion or inhibition of cancer cell proliferation, cellular metabolism (glucose metabolism and lipid metabolism), and promotion or concerted metastasis of cancer cells. The discoveries not only accentuate the depth of ncRNA functionality but also open novel avenues for oncological research and therapeutic innovations. The main difficulties in the study of these ncRNA-derived peptides hinge crucially on precise peptide detection and sORFs identification. Here, we illuminate cutting-edge methodologies, essential instrumentation, and dedicated databases tailored for unearthing sORFs and peptides. In addition, we also conclude the potential of clinical applications in cancer therapy.
         datePublished:2024-06-14T00:00:00Z
         dateModified:2024-06-14T00:00:00Z
         pageStart:1
         pageEnd:17
         license:http://creativecommons.org/publicdomain/zero/1.0/
         sameAs:https://doi.org/10.1186/s12929-024-01047-0
         keywords:
            ncRNA
            Protein
            Peptides
            circRNAs
            lncRNAs
            Cancer
            Biomedicine
            general
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12929-024-01047-0/MediaObjects/12929_2024_1047_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12929-024-01047-0/MediaObjects/12929_2024_1047_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12929-024-01047-0/MediaObjects/12929_2024_1047_Fig3_HTML.png
         isPartOf:
            name:Journal of Biomedical Science
            issn:
               1423-0127
            volumeNumber:31
            type:
               Periodical
               PublicationVolume
         publisher:
            name:BioMed Central
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Kang Wen
               affiliation:
                     name:The Second Affiliated Hospital of Nanjing Medical University
                     address:
                        name:Cancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Xin Chen
               affiliation:
                     name:The Second Affiliated Hospital of Nanjing Medical University
                     address:
                        name:Cancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jingyao Gu
               affiliation:
                     name:The Second Affiliated Hospital of Nanjing Medical University
                     address:
                        name:Cancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Zhenyao Chen
               url:http://orcid.org/0000-0003-0500-6500
               affiliation:
                     name:Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine
                     address:
                        name:Department of Respiratory Endoscopy, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China
                        type:PostalAddress
                     type:Organization
                     name:Shanghai Medical College, Fudan University
                     address:
                        name:Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Zhaoxia Wang
               affiliation:
                     name:The Second Affiliated Hospital of Nanjing Medical University
                     address:
                        name:Cancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Beyond traditional translation: ncRNA derived peptides as modulators of tumor behaviors
      description:Within the intricate tapestry of molecular research, noncoding RNAs (ncRNAs) were historically overshadowed by a pervasive presumption of their inability to encode proteins or peptides. However, groundbreaking revelations have challenged this notion, unveiling select ncRNAs that surprisingly encode peptides specifically those nearing a succinct 100 amino acids. At the forefront of this epiphany stand lncRNAs and circRNAs, distinctively characterized by their embedded small open reading frames (sORFs). Increasing evidence has revealed different functions and mechanisms of peptides/proteins encoded by ncRNAs in cancer, including promotion or inhibition of cancer cell proliferation, cellular metabolism (glucose metabolism and lipid metabolism), and promotion or concerted metastasis of cancer cells. The discoveries not only accentuate the depth of ncRNA functionality but also open novel avenues for oncological research and therapeutic innovations. The main difficulties in the study of these ncRNA-derived peptides hinge crucially on precise peptide detection and sORFs identification. Here, we illuminate cutting-edge methodologies, essential instrumentation, and dedicated databases tailored for unearthing sORFs and peptides. In addition, we also conclude the potential of clinical applications in cancer therapy.
      datePublished:2024-06-14T00:00:00Z
      dateModified:2024-06-14T00:00:00Z
      pageStart:1
      pageEnd:17
      license:http://creativecommons.org/publicdomain/zero/1.0/
      sameAs:https://doi.org/10.1186/s12929-024-01047-0
      keywords:
         ncRNA
         Protein
         Peptides
         circRNAs
         lncRNAs
         Cancer
         Biomedicine
         general
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12929-024-01047-0/MediaObjects/12929_2024_1047_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12929-024-01047-0/MediaObjects/12929_2024_1047_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12929-024-01047-0/MediaObjects/12929_2024_1047_Fig3_HTML.png
      isPartOf:
         name:Journal of Biomedical Science
         issn:
            1423-0127
         volumeNumber:31
         type:
            Periodical
            PublicationVolume
      publisher:
         name:BioMed Central
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Kang Wen
            affiliation:
                  name:The Second Affiliated Hospital of Nanjing Medical University
                  address:
                     name:Cancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xin Chen
            affiliation:
                  name:The Second Affiliated Hospital of Nanjing Medical University
                  address:
                     name:Cancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jingyao Gu
            affiliation:
                  name:The Second Affiliated Hospital of Nanjing Medical University
                  address:
                     name:Cancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Zhenyao Chen
            url:http://orcid.org/0000-0003-0500-6500
            affiliation:
                  name:Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine
                  address:
                     name:Department of Respiratory Endoscopy, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China
                     type:PostalAddress
                  type:Organization
                  name:Shanghai Medical College, Fudan University
                  address:
                     name:Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Zhaoxia Wang
            affiliation:
                  name:The Second Affiliated Hospital of Nanjing Medical University
                  address:
                     name:Cancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Journal of Biomedical Science
      issn:
         1423-0127
      volumeNumber:31
Organization:
      name:BioMed Central
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:The Second Affiliated Hospital of Nanjing Medical University
      address:
         name:Cancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China
         type:PostalAddress
      name:The Second Affiliated Hospital of Nanjing Medical University
      address:
         name:Cancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China
         type:PostalAddress
      name:The Second Affiliated Hospital of Nanjing Medical University
      address:
         name:Cancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China
         type:PostalAddress
      name:Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine
      address:
         name:Department of Respiratory Endoscopy, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China
         type:PostalAddress
      name:Shanghai Medical College, Fudan University
      address:
         name:Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
         type:PostalAddress
      name:The Second Affiliated Hospital of Nanjing Medical University
      address:
         name:Cancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Kang Wen
      affiliation:
            name:The Second Affiliated Hospital of Nanjing Medical University
            address:
               name:Cancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China
               type:PostalAddress
            type:Organization
      name:Xin Chen
      affiliation:
            name:The Second Affiliated Hospital of Nanjing Medical University
            address:
               name:Cancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China
               type:PostalAddress
            type:Organization
      name:Jingyao Gu
      affiliation:
            name:The Second Affiliated Hospital of Nanjing Medical University
            address:
               name:Cancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China
               type:PostalAddress
            type:Organization
      name:Zhenyao Chen
      url:http://orcid.org/0000-0003-0500-6500
      affiliation:
            name:Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine
            address:
               name:Department of Respiratory Endoscopy, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China
               type:PostalAddress
            type:Organization
            name:Shanghai Medical College, Fudan University
            address:
               name:Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Zhaoxia Wang
      affiliation:
            name:The Second Affiliated Hospital of Nanjing Medical University
            address:
               name:Cancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Cancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China
      name:Cancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China
      name:Cancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China
      name:Department of Respiratory Endoscopy, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China
      name:Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
      name:Cancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China

External Links {🔗}(671)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

5.9s.

LINK . SPRINGER . COM {}