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  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
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We began analyzing https://link.springer.com/article/10.1007/s11596-023-2818-2, but it redirected us to https://link.springer.com/article/10.1007/s11596-023-2818-2. The analysis below is for the second page.

Title[redir]:
Top Five Stories of the Cellular Landscape and Therapies of Atherosclerosis: Current Knowledge and Future Perspectives | Current Medical Science
Description:
Atherosclerosis (AS) is characterized by impairment and apoptosis of endothelial cells, continuous systemic and focal inflammation and dysfunction of vascular smooth muscle cells, which is documented as the traditional cellular paradigm. However, the mechanisms appear much more complicated than we thought since a bulk of studies on efferocytosis, transdifferentiation and novel cell death forms such as ferroptosis, pyroptosis, and extracellular trap were reported. Discovery of novel pathological cellular landscapes provides a large number of therapeutic targets. On the other side, the unsatisfactory therapeutic effects of current treatment with lipid-lowering drugs as the cornerstone also restricts the efforts to reduce global AS burden. Stem cell- or nanoparticle-based strategies spurred a lot of attention due to the attractive therapeutic effects and minimized adverse effects. Given the complexity of pathological changes of AS, attempts to develop an almighty medicine based on single mechanisms could be theoretically challenging. In this review, the top stories in the cellular landscapes during the initiation and progression of AS and the therapies were summarized in an integrated perspective to facilitate efforts to develop a multi-targets strategy and fill the gap between mechanism research and clinical translation. The future challenges and improvements were also discussed.

Matching Content Categories {📚}

  • Education
  • Science
  • Health & Fitness

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

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How Does Doi.org Make Money? {💸}

We find it hard to spot revenue streams.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Doi.org could be getting rich in stealth mode, or the way it's monetizing isn't detectable.

Keywords {🔍}

pubmed, article, google, scholar, cas, central, cell, atherosclerosis, cells, biol, vascular, stem, res, chen, endothelial, muscle, smooth, med, zhang, wang, extracellular, ads, mol, ferroptosis, sci, atherosclerotic, death, nanoparticles, mesenchymal, formation, human, thromb, macrophages, macrophage, inflammation, mice, signaling, pathway, pyroptosis, int, plaque, yang, nat, cardiovasc, traps, immunol, arterioscler, vasc, neutrophil, liu,

Topics {✒️}

mir-21-3p/pten-mediated vsmc migration wnt3a-mediated rho/rock/jnk signaling suppressing tlr4/nf-κb/stat3 activation fzd5/wnt/β-catenin pathway mir-125a-5p/tet2 pathway m1-macrophage-derived foam cells lncrna nexn-as1/nexn pathway ccaat/enhancer-binding protein beta tlr4/nf-κb signaling pathway exosomal mir-30d-5p lncrna/circrna-mirna-mrna axis cheng chen & yue-jin yang ask1/jnk/p38 mapk pathway targeting microrna-139-3p/stat1 pathway genetically-modified stem cell article download pdf advanced glycation end-products ox-ldl-induced inflammation oxidized low-density lipoprotein regulating ptp1b/pi3k/akt pathway aggregated low-density lipoprotein stem cell-based therapies ox-ldl-treated huvecs dense low-density lipoprotein z-vad-fmk-induced nuclear s-nitrosylation defines oxldl-induced mmp-2 production /ros/p38 mapk/adam17 pathway solving ischemia-reperfusion injury klf4-dependent phenotypic modulation von köckritz-blickwede von ungern-sternberg sn hyperlipid diet-induced ferroptosis copper-induced cell death extracellular traps derived mir-361/sqstm1/nlrp3 signaling microrna-615-5p regulates angiogenesis canonical nf-κb pathway p53-mediated tumour suppression apoe-deficient bone marrow ampk/mtor-dependent effects circulating mirna profiles nanoparticle-mediated rna interference chitosan-coated insulin liposomes reverses m2 polarization cyclic gmp-amp synthase neutrophil extracellular traps goblet cell-targeting nanoparticles notch-dependent mechanisms common ldl receptor-knockout mice

Questions {❓}

  • Nitric oxide synthase inhibition and oxidative stress in cardiovascular diseases: possible therapeutic targets?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Top Five Stories of the Cellular Landscape and Therapies of Atherosclerosis: Current Knowledge and Future Perspectives
         description:Atherosclerosis (AS) is characterized by impairment and apoptosis of endothelial cells, continuous systemic and focal inflammation and dysfunction of vascular smooth muscle cells, which is documented as the traditional cellular paradigm. However, the mechanisms appear much more complicated than we thought since a bulk of studies on efferocytosis, transdifferentiation and novel cell death forms such as ferroptosis, pyroptosis, and extracellular trap were reported. Discovery of novel pathological cellular landscapes provides a large number of therapeutic targets. On the other side, the unsatisfactory therapeutic effects of current treatment with lipid-lowering drugs as the cornerstone also restricts the efforts to reduce global AS burden. Stem cell- or nanoparticle-based strategies spurred a lot of attention due to the attractive therapeutic effects and minimized adverse effects. Given the complexity of pathological changes of AS, attempts to develop an almighty medicine based on single mechanisms could be theoretically challenging. In this review, the top stories in the cellular landscapes during the initiation and progression of AS and the therapies were summarized in an integrated perspective to facilitate efforts to develop a multi-targets strategy and fill the gap between mechanism research and clinical translation. The future challenges and improvements were also discussed.
         datePublished:2023-12-07T00:00:00Z
         dateModified:2023-12-07T00:00:00Z
         pageStart:1
         pageEnd:27
         license:http://creativecommons.org/licenses/by/4.0/
         sameAs:https://doi.org/10.1007/s11596-023-2818-2
         keywords:
            atherosclerosis
            transdifferentiation
            extracellular traps
            efferocytosis
            stem cell
            nanoparticles
            Medicine/Public Health
            general
         image:
         isPartOf:
            name:Current Medical Science
            issn:
               2523-899X
               2096-5230
            volumeNumber:44
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Huazhong University of Science and Technology
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
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         author:
               name:Qi Pan
               affiliation:
                     name:Chinese Academy of Medical Science and Peking Union Medical College
                     address:
                        name:State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Cheng Chen
               affiliation:
                     name:Chinese Academy of Medical Science and Peking Union Medical College
                     address:
                        name:State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yue-jin Yang
               affiliation:
                     name:Chinese Academy of Medical Science and Peking Union Medical College
                     address:
                        name:State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
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         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Top Five Stories of the Cellular Landscape and Therapies of Atherosclerosis: Current Knowledge and Future Perspectives
      description:Atherosclerosis (AS) is characterized by impairment and apoptosis of endothelial cells, continuous systemic and focal inflammation and dysfunction of vascular smooth muscle cells, which is documented as the traditional cellular paradigm. However, the mechanisms appear much more complicated than we thought since a bulk of studies on efferocytosis, transdifferentiation and novel cell death forms such as ferroptosis, pyroptosis, and extracellular trap were reported. Discovery of novel pathological cellular landscapes provides a large number of therapeutic targets. On the other side, the unsatisfactory therapeutic effects of current treatment with lipid-lowering drugs as the cornerstone also restricts the efforts to reduce global AS burden. Stem cell- or nanoparticle-based strategies spurred a lot of attention due to the attractive therapeutic effects and minimized adverse effects. Given the complexity of pathological changes of AS, attempts to develop an almighty medicine based on single mechanisms could be theoretically challenging. In this review, the top stories in the cellular landscapes during the initiation and progression of AS and the therapies were summarized in an integrated perspective to facilitate efforts to develop a multi-targets strategy and fill the gap between mechanism research and clinical translation. The future challenges and improvements were also discussed.
      datePublished:2023-12-07T00:00:00Z
      dateModified:2023-12-07T00:00:00Z
      pageStart:1
      pageEnd:27
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1007/s11596-023-2818-2
      keywords:
         atherosclerosis
         transdifferentiation
         extracellular traps
         efferocytosis
         stem cell
         nanoparticles
         Medicine/Public Health
         general
      image:
      isPartOf:
         name:Current Medical Science
         issn:
            2523-899X
            2096-5230
         volumeNumber:44
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Huazhong University of Science and Technology
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Qi Pan
            affiliation:
                  name:Chinese Academy of Medical Science and Peking Union Medical College
                  address:
                     name:State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Cheng Chen
            affiliation:
                  name:Chinese Academy of Medical Science and Peking Union Medical College
                  address:
                     name:State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yue-jin Yang
            affiliation:
                  name:Chinese Academy of Medical Science and Peking Union Medical College
                  address:
                     name:State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
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["Periodical","PublicationVolume"]:
      name:Current Medical Science
      issn:
         2523-899X
         2096-5230
      volumeNumber:44
Organization:
      name:Huazhong University of Science and Technology
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Chinese Academy of Medical Science and Peking Union Medical College
      address:
         name:State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
         type:PostalAddress
      name:Chinese Academy of Medical Science and Peking Union Medical College
      address:
         name:State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
         type:PostalAddress
      name:Chinese Academy of Medical Science and Peking Union Medical College
      address:
         name:State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Qi Pan
      affiliation:
            name:Chinese Academy of Medical Science and Peking Union Medical College
            address:
               name:State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
               type:PostalAddress
            type:Organization
      name:Cheng Chen
      affiliation:
            name:Chinese Academy of Medical Science and Peking Union Medical College
            address:
               name:State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
               type:PostalAddress
            type:Organization
      name:Yue-jin Yang
      affiliation:
            name:Chinese Academy of Medical Science and Peking Union Medical College
            address:
               name:State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
      name:State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
      name:State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China

External Links {🔗}(1289)

Analytics and Tracking {📊}

  • Google Tag Manager

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Emails and Hosting {✉️}

Mail Servers:

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CDN Services {📦}

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