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Keywords {🔍}

trafstop, treatment, doi, trafstops, atherosclerosis, cells, figure, cdtraf, mice, macrophages, plaque, cell, pubmed, google, scholar, reduced, expression, activation, immune, figures, pmc, interactions, rhdl, online, atherosclerotic, apoe, plaques, article, traf, signaling, monocytes, treated, free, effects, factor, levels, aortic, weeks, bar, classical, affect, scale, recruitment, macrophage, nfκb, endothelial, bmdms, established, progression, igg,

Topics {✒️}

nuclear factor kappa-light-chain-enhancer mhpc [1-myristoyl-2-hydroxy-sn-glycero-3-phosphocholine] decreasing cd36-mediated lipoprotein uptake rhdl = recombinant high-density lipoprotein long-term antibody-mediated inhibition antigen-specific immunoglobulin responses recombinant high-density lipoprotein traf-stops abolish cd40-traf6 oxidized low-density lipoprotein 2-dimyristoyl-sn-glycero-3-phosphorylcholine] antigen-specific immunoglobulin levels high-density lipoprotein nanoparticles cd40-induced b-cell activation including t-cell proliferation 3-hydroxy-3-methyl-glutaryl-coenzyme noncanonical nf-κb pathway systemic long-term administration bone marrow-derived macrophage induce t-cell proliferation enzyme-linked immunosorbent assay nanomedicine-based strategy allowed comparing traf-stop–treated bmdms anti-cd40 ligand antibody bone marrow-derived macrophages evidence-based pharmaceutical targets long-term cd40 inhibition β2-integrin subunits cd18 target traf-stops specifically preserving cd40-mediated immunity blocking cd40-cd40l interactions traf-stop–treated mice contained pmc beta search nf-κb p65 subunit blocking cd40-traf6 interactions canonical nf-κb pathway canonical nf-kappab2 activation blocking cd40-traf6 signaling ikk/nfκb signaling pathways vivo traf-stop–treated aortas traf-stops specifically inhibit traf-stop treatment resulted cd40-traf wild type divergent cd40-traf interactions traf-stop–treated c57bl6 mice newly identified traf-stops selective cd40-traf6 inhibitors normal b-cell function high-risk high-volume inhibit cd40-induced activation cd40-traf6–mediated increase

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• CD40 signaling in vascular cells: a key role in atherosclerosis?

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