We are analyzing https://link.springer.com/article/10.1007/s11033-022-07725-2.

Title:
Effect of diabetes on efferocytosis process | Molecular Biology Reports
Description:
Diabetes is a complex of genetic, metabolic, and autoimmune disorders that are characterized by hyperglycemia. Elevated apoptotic cell count following defective clearance of dead cells that can cause chronic inflammation is a hallmark of the diabetic wound. Effective dead cell clearance is a prerequisite for rapid inflammation resolution and successful recovery. Efferocytosis is a multistep process in which phagocytes engulf the dead cells. Cell body elimination is of great significance in disease and homeostasis. Recent research has clarified that diabetic wounds have an enhanced load of the apoptotic cell, which is partly attributed to the dysfunction of macrophages in apoptotic clearance at the site of the diabetic wounds. In the current work, we highlight the pathways implicated in efferocytosis, from the diagnosis of apoptotic cells to the phagocytic swallowing and the homeostatic resolution, and explain the possible pathophysiological episodes occurring when the proceeding is abrogated. Also, we describe the last development in the management of inflammation in diabetes wound and future directions of surveillance.
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pubmed, article, google, scholar, cas, diabetes, central, cell, apoptotic, cells, wound, efferocytosis, type, healing, diabetic, macrophage, immunol, medical, clearance, biol, inflammation, med, apoptosis, role, nat, macrophages, sciences, mellitus, university, iran, research, biology, autoimmune, phagocytosis, rev, nature, front, activation, mice, exp, bone, department, medicine, journal, death, blood, inflammatory, promotes, wang, kinase,

Topics {✒️}

ros/mapks/nf-κb/nlrp3 month download article/chapter seyed mohammad gheibihayat anti-cd47 antibody synergizes apoptotic cell-derived exosomes calreticulin receptor-dependent clearance cutaneous ischemia–reperfusion injury mfg-e8 resolves inflammation blocking interleukin-1β induces inflammatory/anti-inflammatory cytokines antigen-specific nanotherapy based autoantigen-loaded phosphatidylserine-liposomes aspirin-triggered epi-lipoxins mannose-binding lectin engagement osteoclast-mediated diabetic osteoporosis osteoclast‐mediated diabetic osteoporosis cutaneous wound healing central nervous system leukocyte-mediated cardiac repair impaired wound healing chronic wound healing injury-site myeloid cells full article pdf protein kinase cδ gas6/mfg-e8 molecular cell biology jamshid gholizadeh navashenaq streptozotocin-induced diabetes wound inflammatory response wound healing dynamics alter wound healing β-cell loss lipoxin stable analogues privacy choices/manage cookies ali ahmadizad firouzjaei biomed research international article mahmoudi related subjects peptide expression patterns apoptotic cell clearance apoptotic β-cells activation-induced apoptosis wound macrophage phenotype author correspondence innate immune cells macrophage inflammatory responses apoptotic cell sensing β-cell death additional information publisher stimulate macrophage chemotaxis

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         description:Diabetes is a complex of genetic, metabolic, and autoimmune disorders that are characterized by hyperglycemia. Elevated apoptotic cell count following defective clearance of dead cells that can cause chronic inflammation is a hallmark of the diabetic wound. Effective dead cell clearance is a prerequisite for rapid inflammation resolution and successful recovery. Efferocytosis is a multistep process in which phagocytes engulf the dead cells. Cell body elimination is of great significance in disease and homeostasis. Recent research has clarified that diabetic wounds have an enhanced load of the apoptotic cell, which is partly attributed to the dysfunction of macrophages in apoptotic clearance at the site of the diabetic wounds. In the current work, we highlight the pathways implicated in efferocytosis, from the diagnosis of apoptotic cells to the phagocytic swallowing and the homeostatic resolution, and explain the possible pathophysiological episodes occurring when the proceeding is abrogated. Also, we describe the last development in the management of inflammation in diabetes wound and future directions of surveillance.
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      headline:Effect of diabetes on efferocytosis process
      description:Diabetes is a complex of genetic, metabolic, and autoimmune disorders that are characterized by hyperglycemia. Elevated apoptotic cell count following defective clearance of dead cells that can cause chronic inflammation is a hallmark of the diabetic wound. Effective dead cell clearance is a prerequisite for rapid inflammation resolution and successful recovery. Efferocytosis is a multistep process in which phagocytes engulf the dead cells. Cell body elimination is of great significance in disease and homeostasis. Recent research has clarified that diabetic wounds have an enhanced load of the apoptotic cell, which is partly attributed to the dysfunction of macrophages in apoptotic clearance at the site of the diabetic wounds. In the current work, we highlight the pathways implicated in efferocytosis, from the diagnosis of apoptotic cells to the phagocytic swallowing and the homeostatic resolution, and explain the possible pathophysiological episodes occurring when the proceeding is abrogated. Also, we describe the last development in the management of inflammation in diabetes wound and future directions of surveillance.
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