We are analyzing https://link.springer.com/article/10.1007/s10557-016-6675-0.

Title:
Reduction of Atherosclerotic Lesions by the Chemotherapeutic Agent Carmustine Associated to Lipid Nanoparticles | Cardiovascular Drugs and Therapy
Description:
After injection in the bloodstream, a lipid nanoparticle (LDE) resembling low-density lipoprotein (LDL) concentrates in atherosclerotic lesions of cholesterol-fed rabbits. Here, rabbits with atherosclerosis were treated with carmustine, an antiproliferative agent used in cancer chemotherapy, associated to LDE to investigate the effects on the lesions. Twenty-seven male New Zealand rabbits were fed a 1 % cholesterol diet for 8 weeks. After 4 weeks nine animals were treated with intravenous saline solution, nine with intravenous LDE alone, and nine with intravenous LDE-carmustine (4 mg/kg, weekly for 4 weeks). LDE-carmustine reduced lesion size by 90 % compared to the controls. LDE-carmustine reduced the presence of macrophages, vascular smooth muscle cells, and regulatory T cells in the arterial intima, as well as the presence of matrix metallopeptidase-9, interleukin-1β and TNF-α and lipoprotein receptors, namely LDL-receptor, LDL-related protein-1, scavenger receptor class B member 1. When injected alone, without association to carmustine, LDE was not different from injected saline solution. LDE-carmustine treatment resulted in marked reduction of lesion area, of the invasion of the arterial intima by macrophages and vascular smooth muscle cells and pro-inflammatory factors. Therefore, this new formulation shows great potential for therapy of atherosclerotic cardiovascular disease.
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Keywords {🔍}

pubmed, article, google, scholar, cas, maranhão, atherosclerosis, atherosclerotic, lipid, lde, rabbits, cells, cancer, cholesterolrich, lipoprotein, treatment, central, pharmacol, disease, cardiovascular, reduction, lesions, carmustine, lowdensity, heart, med, patients, microemulsion, privacy, cookies, content, bulgarelli, raul, ldl, cholesterol, receptors, access, study, etoposide, plasma, nanoemulsion, rodrigues, data, publish, research, search, drugs, therapy, daminelli, resembling,

Topics {✒️}

month download article/chapter cholesterol drug-targeting access resembling low-density lipoprotein related subjects low-density lipoprotein receptors ldl-related protein-1 cholesterol-fed rabbits article cardiovascular drugs full article pdf de vries aj low-density lipoprotein cholesterol-rich nanoemulsions murine primary cholesterol-rich emulsion privacy choices/manage cookies research career award low-density lipoproteins cholesterol-rich microemulsion technological development defective inflammation resolution intravenous saline solution high-density lipoproteins anti-inflammatory therapeutics cholesterol-rich nanoemulsion human atherosclerotic lesions mature whhl rabbits cardiovasc drugs ther acute coronary syndromes hyperlipidemic subjects major precursor lesion atherosclerotic cardiovascular disease acute myeloid-leukemia recurrent cardiovascular events trends mol med lo prete ac intravenous lde-carmustine lde-carmustine reduced invasive drug delivery pro-inflammatory factors oxldl-induced s100a12 espinosa-luna je legorreta-haquet mv preventing ischemic events radiation-induced atheromatosis thin-cap fibroatheroma curr opin cardiol tcrαβ chains associate curr atheroscler rep short-term administration medical school hospital

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         Solid lipid particles (SLP)
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         Drug-targeting
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