We are analyzing https://link.springer.com/article/10.1007/s12011-021-02618-0.

Title:
Dietary Cholesterol Supplements Disturb Copper Homeostasis in Multiple Organs in Rabbits: Aorta Copper Concentrations Negatively Correlate with the Severity of Atherosclerotic Lesions | Biological Trace Element Research
Description:
Dietary cholesterol causes atherosclerosis along with a reduction of copper concentrations in the atherosclerosis wall. This study was to determine the relationship between aorta copper concentrations and the severity of atherosclerotic lesions as well as copper homeostasis in multiple organs in cholesterol-fed rabbits. Male New Zealand white rabbits, 10-week-old and averaged 2.0 kg, were fed a diet containing 1% (w/w) cholesterol or the same diet without cholesterol as controls. Twelve weeks after the feeding, aortic atherosclerotic lesions, serum cholesterol, and multiple organ copper concentrations were measured. Compared to controls, rabbits fed cholesterol-supplemented diet displayed higher serum cholesterol levels and developed atherosclerosis. Copper concentrations in the cholesterol-fed rabbits were increased in the serum and kidney but decreased in the atherosclerosis wall and multiple organs, including heart, liver, spleen, and lung. Furthermore, aorta copper concentrations negatively correlated, respectively, with the severity of the atherosclerotic lesion (r = − 0.64, p = 0.01), the microscope atherosclerotic lesion area (r = − 0.60, p = 0.02), and the stenosis of the lumen (r = − 0.54, p = 0.04). Dietary cholesterol not only causes atherosclerosis but also disturbs copper homeostasis in multiple organ systems. The negative correlation between aorta copper concentrations and the severity of atherosclerotic lesions suggests a vicious cycle between copper reduction and the pathogenesis of atherosclerosis. These changes in copper homeostasis would be additive to atherosclerosis as a risk factor for cardiovascular disease in humans.
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Keywords {🔍}

article, pubmed, google, scholar, copper, cas, atherosclerosis, cholesterol, atherosclerotic, dietary, rabbits, biol, serum, concentrations, central, httpsdoiorgs, lipoprotein, lesions, res, research, james, kang, oxidation, httpsdoiorg, trace, homeostasis, multiple, aorta, cholesterolfed, access, metabolism, ferns, exp, med, deficiency, privacy, cookies, content, information, severity, wang, aortic, lesion, lamb, role, ldl, lipid, rats, nutr, data,

Topics {✒️}

month download article/chapter pathologischer prozesse central serum low-density lipoprotein writing—original draft preparation coronary artery diseases full article pdf copper-mediated ldl oxidation dietary copper supplementation metal ions disturbs copper homeostasis privacy choices/manage cookies aortic atherosclerotic lesions related subjects low density lipoprotein low-density lipoprotein cholesterol-fed rabbits west china hospital aorta copper concentrations cholesterol-fed rabbit lei ky plaque copper concentration van lenten bj lamb dj abdominal aorta sampling atherosclerotic lesion area total serum cholesterol van allen cm macrophage antimicrobial pathways writing—original draft article li atherosclerosis research suprarenal abdominal artery european economic area marginal copper deficiency zealand white rabbits exp biol med carl von rokitansky acute coronary syndromes inter-species differences cellular thiol production zinc supplements tan kwong huat klevay lm gradient gel electrophoresis endogenously elicited antibodies acknowledge zhenghui luo institutional animal care cross-section quantification high resolution image copper supplementation effects

Questions {❓}

Rajendran R, Ren M, Ning P, Tan Kwong Huat B, Halliwell B, Watt F (2007) Promotion of atherogenesis by copper or iron--which is more likely?

Schema {🗺️}

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         description:Dietary cholesterol causes atherosclerosis along with a reduction of copper concentrations in the atherosclerosis wall. This study was to determine the relationship between aorta copper concentrations and the severity of atherosclerotic lesions as well as copper homeostasis in multiple organs in cholesterol-fed rabbits. Male New Zealand white rabbits, 10-week-old and averaged 2.0 kg, were fed a diet containing 1% (w/w) cholesterol or the same diet without cholesterol as controls. Twelve weeks after the feeding, aortic atherosclerotic lesions, serum cholesterol, and multiple organ copper concentrations were measured. Compared to controls, rabbits fed cholesterol-supplemented diet displayed higher serum cholesterol levels and developed atherosclerosis. Copper concentrations in the cholesterol-fed rabbits were increased in the serum and kidney but decreased in the atherosclerosis wall and multiple organs, including heart, liver, spleen, and lung. Furthermore, aorta copper concentrations negatively correlated, respectively, with the severity of the atherosclerotic lesion (r = − 0.64, p = 0.01), the microscope atherosclerotic lesion area (r = − 0.60, p = 0.02), and the stenosis of the lumen (r = − 0.54, p = 0.04). Dietary cholesterol not only causes atherosclerosis but also disturbs copper homeostasis in multiple organ systems. The negative correlation between aorta copper concentrations and the severity of atherosclerotic lesions suggests a vicious cycle between copper reduction and the pathogenesis of atherosclerosis. These changes in copper homeostasis would be additive to atherosclerosis as a risk factor for cardiovascular disease in humans.
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      description:Dietary cholesterol causes atherosclerosis along with a reduction of copper concentrations in the atherosclerosis wall. This study was to determine the relationship between aorta copper concentrations and the severity of atherosclerotic lesions as well as copper homeostasis in multiple organs in cholesterol-fed rabbits. Male New Zealand white rabbits, 10-week-old and averaged 2.0 kg, were fed a diet containing 1% (w/w) cholesterol or the same diet without cholesterol as controls. Twelve weeks after the feeding, aortic atherosclerotic lesions, serum cholesterol, and multiple organ copper concentrations were measured. Compared to controls, rabbits fed cholesterol-supplemented diet displayed higher serum cholesterol levels and developed atherosclerosis. Copper concentrations in the cholesterol-fed rabbits were increased in the serum and kidney but decreased in the atherosclerosis wall and multiple organs, including heart, liver, spleen, and lung. Furthermore, aorta copper concentrations negatively correlated, respectively, with the severity of the atherosclerotic lesion (r = − 0.64, p = 0.01), the microscope atherosclerotic lesion area (r = − 0.60, p = 0.02), and the stenosis of the lumen (r = − 0.54, p = 0.04). Dietary cholesterol not only causes atherosclerosis but also disturbs copper homeostasis in multiple organ systems. The negative correlation between aorta copper concentrations and the severity of atherosclerotic lesions suggests a vicious cycle between copper reduction and the pathogenesis of atherosclerosis. These changes in copper homeostasis would be additive to atherosclerosis as a risk factor for cardiovascular disease in humans.
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