We are analyzing https://link.springer.com/article/10.1186/s40580-021-00285-4.

Title:
Effect of biochemical and biomechanical factors on vascularization of kidney organoid-on-a-chip | Nano Convergence
Description:
Kidney organoids derived from the human pluripotent stem cells (hPSCs) recapitulating human kidney are the attractive tool for kidney regeneration, disease modeling, and drug screening. However, the kidney organoids cultured by static conditions have the limited vascular networks and immature nephron-like structures unlike human kidney. Here, we developed a kidney organoid-on-a-chip system providing fluidic flow mimicking shear stress with optimized extracellular matrix (ECM) conditions. We demonstrated that the kidney organoids cultured in our microfluidic system showed more matured podocytes and vascular structures as compared to the static culture condition. Additionally, the kidney organoids cultured in microfluidic systems showed higher sensitivity to nephrotoxic drugs as compared with those cultured in static conditions. We also demonstrated that the physiological flow played an important role in maintaining a number of physiological functions of kidney organoids. Therefore, our kidney organoid-on-a-chip system could provide an organoid culture platform for in vitro vascularization in formation of functional three-dimensional (3D) tissues.
Website Age:
28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

kidney, organoids, article, google, scholar, organoidonachip, cas, shear, stress, flow, cells, organoid, differentiation, culture, blood, fluidic, cultured, condition, conditions, vessel, vegf, fig, vascularization, formation, maturation, human, static, vitro, cell, factors, system, expression, data, drug, vascular, ecm, surface, usa, biomechanical, lee, korea, days, tacrolimus, analysis, effect, kim, stem, development, ecs, wall,

Topics {✒️}

yong kyun kim bong guen chung jin won kim cross-sectional velocity profiles single-phased laminar flow ji wook choi incompressible naiver–stokes equation millimeter-scale microfluidic system hpscs-derived kidney organoids high-throughput drug screening matrigel/vegf-coated kidney organoid increased vascular-related cells kidney antibody-specific area vivo-related physiological stimulations uniform-sized kidney organoids article download pdf kidney-related cell types pecam1-positive protein levels kidney organoid-mediated neovascularization kidney antibody-specific markers tacrolimus dose-dependent manner simulated cross-sectional streamline hpscs-induced kidney organoids fluidic flow-generated microenvironments yoon young choi live/dead analysis revealed enhanced pecam1-positive expression young seo lee article google scholar tacrolimus-treated kidney organoids privacy choices/manage cookies shear stress induced fluidic shear stress matrigel-coated kidney organoid nano convergence 8 matrigel/vegf-coated group pecam1-positive ecs increased kidney-related area microfluidic system showed shear stress acting full access wall shear stress microfluidic culture system stem cell technologies dose dependent manner higher shear stress bone morphogenic protein-4 laminar shear stress traction stresses generated cell–cell interactions

Schema {🗺️}

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         headline:Effect of biochemical and biomechanical factors on vascularization of kidney organoid-on-a-chip
         description:Kidney organoids derived from the human pluripotent stem cells (hPSCs) recapitulating human kidney are the attractive tool for kidney regeneration, disease modeling, and drug screening. However, the kidney organoids cultured by static conditions have the limited vascular networks and immature nephron-like structures unlike human kidney. Here, we developed a kidney organoid-on-a-chip system providing fluidic flow mimicking shear stress with optimized extracellular matrix (ECM) conditions. We demonstrated that the kidney organoids cultured in our microfluidic system showed more matured podocytes and vascular structures as compared to the static culture condition. Additionally, the kidney organoids cultured in microfluidic systems showed higher sensitivity to nephrotoxic drugs as compared with those cultured in static conditions. We also demonstrated that the physiological flow played an important role in maintaining a number of physiological functions of kidney organoids. Therefore, our kidney organoid-on-a-chip system could provide an organoid culture platform for in vitro vascularization in formation of functional three-dimensional (3D) tissues.
         datePublished:2021-11-08T00:00:00Z
         dateModified:2021-11-08T00:00:00Z
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            Shear stress
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            Podocyte
            Nanotechnology
            Nanoscale Science and Technology
            Nanotechnology and Microengineering
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      headline:Effect of biochemical and biomechanical factors on vascularization of kidney organoid-on-a-chip
      description:Kidney organoids derived from the human pluripotent stem cells (hPSCs) recapitulating human kidney are the attractive tool for kidney regeneration, disease modeling, and drug screening. However, the kidney organoids cultured by static conditions have the limited vascular networks and immature nephron-like structures unlike human kidney. Here, we developed a kidney organoid-on-a-chip system providing fluidic flow mimicking shear stress with optimized extracellular matrix (ECM) conditions. We demonstrated that the kidney organoids cultured in our microfluidic system showed more matured podocytes and vascular structures as compared to the static culture condition. Additionally, the kidney organoids cultured in microfluidic systems showed higher sensitivity to nephrotoxic drugs as compared with those cultured in static conditions. We also demonstrated that the physiological flow played an important role in maintaining a number of physiological functions of kidney organoids. Therefore, our kidney organoid-on-a-chip system could provide an organoid culture platform for in vitro vascularization in formation of functional three-dimensional (3D) tissues.
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         Vascular structure
         Podocyte
         Nanotechnology
         Nanoscale Science and Technology
         Nanotechnology and Microengineering
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      name:Department of Mechanical Engineering, Sogang University, Seoul, South Korea
      name:Department of Mechanical Engineering, Sogang University, Seoul, South Korea
      name:Department of Chemical and Biomolecular Engineering, Sogang University, Seoul, South Korea
      name:Cell Death Disease Research Center, College of Medicine, The Catholic University of Korea, Seoul, South Korea
      name:Department of Internal Medicine, College of Medicine, The Catholic University of Korea, St. Vincent’s Hospital, Suwon, South Korea
      name:Department of Mechanical Engineering, Sogang University, Seoul, South Korea

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