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NATURE . COM {}

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We are analyzing https://www.nature.com/articles/s41594-018-0164-z.

Title:
Structural and molecular mechanisms for the control of eukaryotic 5′–3′ mRNA decay | Nature Structural & Molecular Biology
Description:
5′–3′ RNA decay pathways are critical for quality control and regulation of gene expression. Structural and biochemical studies have provided insights into the key nucleases that carry out deadenylation, decapping, and exonucleolysis during 5′–3′ decay, but detailed understanding of how these activities are coordinated is only beginning to emerge. Here we review recent mechanistic insights into the control of 5′–3′ RNA decay, including coupling between translation and decay, coordination between the complexes and activities that process 5′ and 3′ RNA termini, conformational control of enzymatic activity, liquid phase separation, and RNA modifications. This Review discusses mechanistic insights into 5´–3´ RNA decay, such as translation–decay coupling, coordination between complexes that process 5´ & 3´ RNA termini, conformational control of enzymatic activity, phase separation, & RNA modifications.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Education
  • Business & Finance
  • Telecommunications

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌆 Monumental Traffic: 20M - 50M visitors per month


Based on our best estimate, this website will receive around 42,799,894 visitors per month in the current month.

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How Does Nature.com Make Money? {💸}


Display Ads {🎯}


The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

Ads are managed by yourbow.com. Particular relationships are as follows:

Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.com

Reseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.com

How Much Does Nature.com Make? {💰}


Display Ads {🎯}

$539,300 per month
Estimations show Nature.com's display ad online revenue falls between $359,561 and $988,793 per month.

Keywords {🔍}

pubmed, google, scholar, cas, central, mrna, cell, rna, mol, decapping, biol, nature, complex, nat, decay, structural, article, struct, eukaryotic, dcp, control, gene, translation, ccrnot, gross, deadenylation, access, protein, stability, rev, reveals, molecular, coller, expression, basis, structure, parker, res, content, biology, regulation, sci, degradation, nucleic, acids, cookies, analysis, december, biochem, mrnas,

Topics {✒️}

ribosome-ski2-ski3-ski8 helicase complex nature portfolio journals permissions reprints nature portfolio privacy policy advertising scrna-seq data reveals social media dcp2 c-terminal domain author information authors dcp2-dcp1 mrna-decapping complex nature+ nature 461 nature 541 nature 505 nature microrna-mediated gene silencing nonsense-mediated mrna decay /ddx6/cnot1 complex reveals author correspondence p-body purification reveals transcriptional n6-adenosine methylation mirna-mediated gene silencing rna-mediated gene silencing rna-binding protein gigyf2 n6-methyladenosine-dependent regulation nuclease complex stimulated nuclear mrna decay marbles directly interacts permissions personal data springerlink instant access genome-wide mapping genome-wide determination translational mrna decay cotranslational rna decay data protection eukaryotic yth domain messenger rna stability quantifying 3′utr length cellular phase-transition process cleaved transcripts reveals selective mrna decay au-rich elements privacy disordered protein regions ddx6-cnot1 complex promote translational silencing eukaryotic gene expression dhh1 engages pat1

Questions {❓}

  • AU-rich elements and associated factors: are there unifying principles?

Schema {🗺️}

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         description:5′–3′ RNA decay pathways are critical for quality control and regulation of gene expression. Structural and biochemical studies have provided insights into the key nucleases that carry out deadenylation, decapping, and exonucleolysis during 5′–3′ decay, but detailed understanding of how these activities are coordinated is only beginning to emerge. Here we review recent mechanistic insights into the control of 5′–3′ RNA decay, including coupling between translation and decay, coordination between the complexes and activities that process 5′ and 3′ RNA termini, conformational control of enzymatic activity, liquid phase separation, and RNA modifications. This Review discusses mechanistic insights into 5´–3´ RNA decay, such as translation–decay coupling, coordination between complexes that process 5´ & 3´ RNA termini, conformational control of enzymatic activity, phase separation, & RNA modifications.
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      headline:Structural and molecular mechanisms for the control of eukaryotic 5′–3′ mRNA decay
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