
NCBI . NLM . NIH . GOV {
}
Title[redir]:
BTG/TOB factors impact deadenylases - PMC
Description:
BTG/TOB factors are a family of antiproliferative proteins whose expression is altered in numerous cancers. They have been implicated in cell differentiation, development and apoptosis. Although proposed to affect transcriptional regulation, these ...
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Keywords {π}
doi, pubmed, google, scholar, btgtob, mrna, deadenylation, proteins, tob, caf, btg, pmc, article, deadenylase, protein, family, free, cell, interaction, complex, biol, factors, expression, antiproliferative, conserved, activity, polya, human, domain, apro, pabp, translation, role, figure, residues, transcriptional, gene, members, control, degradation, interact, factor, structure, chem, mol, function, cancer, genes, involved, mrnas,
Topics {βοΈ}
hgnc_id=1130b-cell translocation gene/http anti-parallel Ξ²-sheet btg/tob physical links transcriptional pulse-chase strategies transcriptional pulse-chase approach anti-proliferative protein tob btg/tob functional links protein-arginine n-methyltransferase immunoprecipitated caf1βtob complex tis21/pc3/btg1/tob family btg/tob biological functions mitogen-activated protein kinases transcriptional pulse-chase experiments pmc beta search btg/tob proteins exert btg/tob proteins relay Ξ²-globin mrna reporter btg/tob partners suggests btg/tob activity displays btg/tob protein partners p53-inducible gene pc3 btg/tob induced deadenylation btg/tob protein family tob1n138βcaf1 complexes support btg/tob-activated deadenylation btg/tob physiological functions binding cyclin-dependent kinases osteoporotic bone formation pc3/btg/tob family btg/tob-mediated deadenylation nonsense-mediated mrna decay taobn138βcaf1 complex reveals trends biochem sci common n-terminal domain ras-mediated cell proliferation human btg/tob proteins n-terminal apro domain activate caf1-dependent deadenylation btg/tob family function bmp/smad signaling tob1 n-terminal domain pan2βpan3 deadenylase complex activates caf1-dependent deadenylation cap binding factors supplementary materials included anti-proliferative activity Ξ²-globin reporter specific protein modification heterodimeric deadenylase complexes multiple signaling pathways
Questions {β}
- The gene PC3(TIS21/BTG2), prototype member of the PC3/BTG/TOB family: regulator in control of cell growth, differentiation, and DNA repair?
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