
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Cytoplasmic deadenylation: Regulation of mRNA fate - PMC
Description:
The poly(A) tail of mRNA has an important influence on the dynamics of gene expression. On one hand, it promotes enhanced mRNA stability to allow production of the protein, even after inactivation of transcription. On the other hand, shortening of ...
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Keywords {π}
doi, deadenylation, complex, pubmed, google, scholar, mrna, ccrnot, polya, pmc, article, proteins, free, biol, mrnas, deadenylase, cell, tail, expression, translation, yeast, mol, gene, control, regulation, ccrp, degradation, rna, protein, specific, function, decay, eukaryotes, binding, tails, activity, notp, popp, nat, translational, pan, subunits, ccr, nlm, stability, transcription, role, roles, regulated, length,
Topics {βοΈ}
ubc4p/ubc5p-mediated stress responses microrna-mediated gene silencing transcription factor iid rna-induced silencing complexes mirna-mediated gene silencing mirna-induced deadenylation requires mirna-induced deadenylation [5] c-terminal region deadenylating nuclease pmc beta search nac nascent polypeptide mitotic cell-cycle progression e3 ubiquitin ligase not4p-mediated protein degradation cpeb4-dependent translational control heterodimeric nascent polypeptide nucleic acids res protein-targeted deadenylation cell cycle-related genes affect pabp-dependent deadenylation cell-cycle regulated genes biochem soc trans rnai screen mirna-mediated repression 3β² untranslated regions specific ribonuclease transcription factor publisher site pdf eukaryotic mrna turnover promote translation initiation nat rev genet annu rev biochem polypeptide exit tunnel key factor nascent polypeptide nuclease domain belonging translation initiation occurs facilitates chromatin modifications demethylase jhd2p/jarid1c nat cell biol rna nuclease essential protect nascent chains mol cell biol mol biol cell mirisc recruits mammalian mrna turnover regulate messenger rnas puf family portrait early drosophila embryo protein synthesis occurs
Questions {β}
- For example, what is the relationship between different deadenylases, specifically the Ccr4-Not and Pan complexes?
- Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?
- The eukaryotic Ccr4-not complex: a regulatory platform integrating mRNA metabolism with cellular signaling pathways?
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