We are analyzing https://link.springer.com/article/10.1186/s12943-020-01238-x.

Title:
Natural killer cells in cancer biology and therapy | Molecular Cancer
Description:
The tumor microenvironment is highly complex, and immune escape is currently considered an important hallmark of cancer, largely contributing to tumor progression and metastasis. Named for their capability of killing target cells autonomously, natural killer (NK) cells serve as the main effector cells toward cancer in innate immunity and are highly heterogeneous in the microenvironment. Most current treatment options harnessing the tumor microenvironment focus on T cell-immunity, either by promoting activating signals or suppressing inhibitory ones. The limited success achieved by T cell immunotherapy highlights the importance of developing new-generation immunotherapeutics, for example utilizing previously ignored NK cells. Although tumors also evolve to resist NK cell-induced cytotoxicity, cytokine supplement, blockade of suppressive molecules and genetic engineering of NK cells may overcome such resistance with great promise in both solid and hematological malignancies. In this review, we summarized the fundamental characteristics and recent advances of NK cells within tumor immunometabolic microenvironment, and discussed potential application and limitations of emerging NK cell-based therapeutic strategies in the era of presicion medicine.
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Keywords {🔍}

cells, pubmed, google, scholar, cell, cas, cancer, central, killer, natural, tumor, immunol, human, immune, immunity, clinical, blood, function, receptor, receptors, expression, patients, cytotoxicity, activation, antitumor, therapy, innate, wang, nat, blockade, metabolic, tumors, breast, molecules, development, microenvironment, effects, res, clin, immunotherapy, response, activity, cytokine, inkt, including, treatment, activating, responses, functions, nkp,

Topics {✒️}

high-dimensional single-cell rna-seq il-15-responsive ifn-gamma-producing cells cytokine-inducible sh2-containg protein antibody-dependent cell-mediated cytotoxicity nk-mediated anti-tumor immunotherapy time-resolved single-cell assay t-cell-dependent tumor activity ifn-gamma-nonsecreting nk cells ic9/car-cd19/il-15 nk cells cd49a+cd56+cd3−cd19− nk cells zhi-ming shao generate natural-killer-cell diversity β-n-acetylhexosaminidase gm-cfs yi-zhou jiang natural killer-cell counts natural killer-mediated cytotoxicity long-lived nk cells monoclonal antibody-based immunotherapy natural killer-mediated lysis anti-pd-1/pd-l1 therapies transforming growth factor-β high-mobility group box 1 graft-versus-host responses b-cell lymphoblastic leukemia nk cell-mediated suppression myeloid-derived suppressor cells nk cell-based vaccines include tissue-resident nk recognizing b7-h6 expressed single-chain variable fragment nk cell-mediated killing nk cell-related immunotherapy single-cell transcriptome ananlysis paired single-cell analyses nk cell-based therapies cd3−cd16+cd56+ cells reflect inhibitory nkr-p1b receptor including fda-approved anti-ctla-4 lack mhc-i-related molecules hypoxia inducible factor-1α nk cell-based therapy anti-kir antibody iph2101 nk cell-based microenvironment enhances anti-tumor activity specific anti-tumor cytotoxicity nk cell-based immunity 27-hydroxycholesterol promotes cell-autonomous anti-pd-1 monoclonal antibody human cytokine-induced memory acute myelogenous leukemia/aml

Questions {❓}

A Small Region of the Natural Killer Cell Receptor, Siglec-7, Is Responsible for Its Preferred Binding to ?
Innate or adaptive immunity?
Is the tumor infiltrating natural killer cell (NK-TILs) count in infiltrating ductal carcinoma of breast prognostically significant?

Schema {🗺️}

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         description:The tumor microenvironment is highly complex, and immune escape is currently considered an important hallmark of cancer, largely contributing to tumor progression and metastasis. Named for their capability of killing target cells autonomously, natural killer (NK) cells serve as the main effector cells toward cancer in innate immunity and are highly heterogeneous in the microenvironment. Most current treatment options harnessing the tumor microenvironment focus on T cell-immunity, either by promoting activating signals or suppressing inhibitory ones. The limited success achieved by T cell immunotherapy highlights the importance of developing new-generation immunotherapeutics, for example utilizing previously ignored NK cells. Although tumors also evolve to resist NK cell-induced cytotoxicity, cytokine supplement, blockade of suppressive molecules and genetic engineering of NK cells may overcome such resistance with great promise in both solid and hematological malignancies. In this review, we summarized the fundamental characteristics and recent advances of NK cells within tumor immunometabolic microenvironment, and discussed potential application and limitations of emerging NK cell-based therapeutic strategies in the era of presicion medicine.
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      headline:Natural killer cells in cancer biology and therapy
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