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Title[redir]:
IFN-γ–related mRNA profile predicts clinical response to PD-1 blockade - PMC
Description:
Programmed death-1–directed (PD-1–directed) immune checkpoint blockade results in durable antitumor activity in many advanced malignancies. Recent studies suggest that IFN-γ is a critical driver of programmed death ligand-1 (PD-L1) expression in ...
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Keywords {🔍}
response, gene, tumor, cancer, patients, doi, clinical, immune, data, expression, keynote, genes, cells, ifnγ, cell, pdl, cellinflamed, signatures, signature, google, scholar, melanoma, hnscc, tumors, pubmed, blockade, set, figure, gep, pmc, checkpoint, pembrolizumab, results, microenvironment, gastric, antipd, article, types, free, biology, cohort, final, signaling, objective, pfs, cohorts, study, roc, therapy, tissue,
Topics {✒️}
wnt/β-catenin pathway activation pd-1–/pd-l1–directed monoclonal antibodies anti-pd-l1 antibody mpdl3280a converting anti–pd-1–resistant tumors ifn-γ–related gene signatures pd-1/pd-l1 signaling pathway interferon-γ-induced activation anti–pd-1 monoclonal antibodies il2rg [encoding il-2rγ] ifn-γ–mediated induction transcript-specific ternary complexes ifn-γ signaling processes ifn-γ signaling enables ifn-γ signaling pathway immune-related gene expression improved progression-free survival formalin-fixed paraffin-embedded immune-related gene signatures pre-enrollment ihc screening active ifn-γ signaling pmc beta search pd-l1–unselected populations cell–inflamed gep score preliminary ifn-γ signature increased anti–pd-1 efficacy cell–inflamed gep suggests including ifn-γ signaling triple-negative breast cancer anti–pd-1 therapy fall pmc copyright notice clinical-grade diagnostic device ifn-γ 10-gene signature ifn-γ 6-gene signature anti–pd-1–responsive tumors clinical trial–grade assay cell–inflamed gep compared cd8+ t-cell recruitment small-cell lung cancer turn produce chemokines/chemoattractants anti-pd-l1 immunotherapy yielding refined “ifn-γ increased pd-l1 expression anti–pd-1 therapy compared pd-l1–unselected cohort tumor type–independent applicability pd-1–directed therapy response cell–inflamed microenvironment common pd-l1–unselected patients 96 pd-l1–unselected patients publisher site pdf
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