
NCBI . NLM . NIH . GOV {
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Title[redir]:
IL-21-mediated reversal of NK cell exhaustion facilitates anti-tumour immunity in MHC class I-deficient tumours - PMC
Description:
During cancer immunoediting, loss of major histocompatibility complex class I (MHC-I) in neoplasm contributes to the evasion of tumours from host immune system. Recent studies have demonstrated that most natural killer (NK) cells that are found in ...
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Keywords {🔍}
cells, tumour, mice, tumours, class, mhc, tim, fig, expression, cell, doi, pubmed, google, scholar, timpd, cancer, supplementary, ideficient, hkb, hdb, data, ifnγ, pmc, human, article, exhaustion, exhausted, patients, free, nkcell, day, analysed, intratumoural, immune, cytotoxicity, bmoαgc, responses, functional, induced, stat, vaccine, vaccination, studies, natural, killer, bearing, isolated, addition, receptors, activation,
Topics {✒️}
nkt-cell-ligand-loaded antigen-presenting cell mhc-class-i-independent natural-killer-cell malignant mhc-i-deficient tumours pd-1/pd-l1 axis modulates e6/e7 tumour ag /mo/e6e7/αgc elicited activation h-2db ko-bearing mice specific pathogen-free vivarium /mo/tag/αgc effectively eradicated /mo/tag/αgc vaccine expressing 51cr-labelled tc-1 h-2kb /mo/e6e7/αgc-immunized mice b-cell-based vaccine transduced anti-il-21r-blocking ab anti-il-21r blocking ab mhc class i-sufficient mouse cd1d-pbs-57-loaded tetramers ifn-γ-producing nk cells anti-ifn-γ-neutralizing ab /mo/αgc administration resulted nk-cell-dependent immune control mhc class i-downregulation mhc class i-deficiency human nk-cell-activating receptors high protein-binding plates /mo/tag/αgc vaccination restored tumor antigen-specific cd8+ transcription factor t-bet /mo/αgc effectively controls ifn-γ-reporter-eyfp ifn-γ-eyfp-reporter pmc beta search tumour-draining lymph nodes anti-tumor antigen antibodies dendritic cell-derived exosomes h-2db ko tumours β2m-deficient hela cells low-expressing tumour cells jα281-deficient mice failed expand antigen-specific cd8+ inducing anti-tumour effects46 enzyme-linked immunosorbent assay pi3k-akt-foxo1 axis h-2db ko cells t-bet transcription factors suppresses cell-mediated cytotoxicity h-2db ko implantation paraffin-embedded tissue sections inhibiting t-bet expression34 nkt-cell-dependent manner
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