
NCBI . NLM . NIH . GOV {
}
Title[redir]:
An Integrated View of Immunometabolism - PMC
Description:
The worldwide obesity epidemic has emerged as a major cause of insulin resistance and Type 2 diabetes. Chronic tissue inflammation is a well-recognized feature of obesity, and the field of immunometabolism has witnessed many advances in recent ...
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🌠 Phenomenal Traffic: 5M - 10M visitors per month
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Keywords {🔍}
google, scholar, doi, pubmed, insulin, pmc, free, article, tissue, cells, resistance, adipose, inflammation, obesity, cell, diabetes, metabolic, effects, macrophages, immune, proinflammatory, liver, increased, mice, sensitivity, obese, type, glucose, inflammatory, lee, βcell, activation, metab, clin, studies, muscle, humans, signaling, role, treatment, cytokines, macrophage, expression, chronic, antiinflammatory, metabolism, islets, decreased, olefsky, factors,
Topics {✒️}
nuclear factor κ-light-chain-enhancer yolk-sac-derived erythro-myeloid progenitors peroxisome proliferator-activated receptor-gamma tumor necrosis factor-alpha c-jun n-terminal kinase activating g-protein-coupled receptors dual-energy x-ray absorptiometry tumor necrosis factor-α amp-activated protein kinase egln-hif o2-sensing system high-fat diet-induced obesity irs/pi3k/akt signaling pathway yolk-sac-derived resident macrophages palmitate-induced β-cell dysfunction high-fat diet-fed mice current anti-tnf-α biologics cytokine-induced nf-κb activation bone-marrow-derived blood monocytes tzd-mediated anti-inflammatory effects β-cell-specific gene expression ob/ob control mice inflammation-induced β-cell dysfunction bone-marrow-derived recruited macrophages pmc beta search large-scale placebo-controlled studies anti-tnf-α antibodies leads clear-cut anti-inflammatory effects short-chain fatty acids feeding high-fat diet alpha2-heremans-schmid glycoprotein/fetuin fatty-acid-induced uncoupling tumor necrosis factor insulin-sensitizing anti-diabetic actions large-scale “omics” data [google scholar] eguchi [google scholar] patsouris free fatty acids insulin-stimulated glucose disposal fat-rich diet activates brain-derived neutrophic factor diet-induced insulin resistance immune-cell-type-specific depletion cell-permeable peptide inhibitors methicillin-resistant staphylococcus aureus increased β-cell apoptosis anti-il-1β antibody diet-induced obese mice specific anti-inflammatory approaches sex hormone-binding globulin β arrestin-2-dependent pathway
Questions {❓}
- Insulin-Sensitizing Effects of Omega-3 Fatty Acids: Lost in Translation?
- Metabolomics and Metabolic Diseases: Where Do We Stand?
Social Networks {👍}(6)
External Links {🔗}(494)
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- What's the total monthly financial gain of https://doi.org/10.1038/nri1841?
- What is the monthly revenue of https://scholar.google.com/scholar_lookup?journal=Nat.%20Rev.%20Immunol&title=Neutrophil%20serine%20proteases:%20specific%20regulators%20of%20inflammation&author=CT%20Pham&volume=6&publication_year=2006&pages=541-550&pmid=16799473&doi=10.1038/nri1841&?
- What's the monthly income of https://doi.org/10.1016/j.jhep.2010.12.004?
- Get to know https://scholar.google.com/scholar_lookup?journal=J.%20Hepatol&title=The%20bile%20acid%20membrane%20receptor%20TGR5%20as%20an%20emerging%20target%20in%20metabolism%20and%20inflammation&author=TW%20Pols&author=LG%20Noriega&author=M%20Nomura&author=J%20Auwerx&author=K%20Schoonjans&volume=54&publication_year=2011&pages=1263-1272&pmid=21145931&doi=10.1016/j.jhep.2010.12.004&'s earnings
- See how much https://doi.org/10.1210/jc.2014-2682 makes per month
- How much does https://scholar.google.com/scholar_lookup?journal=J.%20Clin.%20Endocrinol.%20Metab&title=Hypothalamic%20damage%20is%20associated%20with%20inflammatory%20markers%20and%20worse%20cognitive%20performance%20in%20obese%20subjects&author=J%20Puig&author=G%20Blasco&author=J%20Daunis-I-Estadella&author=X%20Molina&author=G%20Xifra&volume=100&publication_year=2015&pages=E276-E281&pmid=25423565&doi=10.1210/jc.2014-2682& net monthly?
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- What's the revenue for https://scholar.google.com/scholar_lookup?journal=Cell%20Metab&title=Ancillary%20Activity:%20Beyond%20Core%20Metabolism%20in%20Immune%20Cells&author=DJ%20Puleston&author=M%20Villa&author=EL%20Pearce&volume=26&publication_year=2017&pages=131-141&pmid=28683280&doi=10.1016/j.cmet.2017.06.019&?
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- How much revenue does https://scholar.google.com/scholar_lookup?journal=Cell%20Metab&title=Adipocyte%20CREB%20promotes%20insulin%20resistance%20in%20obesity&author=L%20Qi&author=M%20Saberi&author=E%20Zmuda&author=Y%20Wang&author=J%20Altarejos&volume=9&publication_year=2009&pages=277-286&pmid=19254572&doi=10.1016/j.cmet.2009.01.006& generate?
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- https://doi.org/10.1146/annurev-physiol-021115-105305's total income per month
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- How much does https://scholar.google.com/scholar_lookup?journal=Nat.%20Med&title=Netrin-1%20promotes%20adipose%20tissue%20macrophage%20retention%20and%20insulin%20resistance%20in%20obesity&author=B%20Ramkhelawon&author=EJ%20Hennessy&author=M%20M%C3%A9nager&author=TD%20Ray&author=FJ%20Sheedy&volume=20&publication_year=2014&pages=377-384&pmid=24584118&doi=10.1038/nm.3467& pull in?
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- What's the revenue for https://scholar.google.com/scholar_lookup?journal=Nat.%20Med&title=An%20inhibitor%20of%20the%20protein%20kinases%20TBK1%20and%20IKK-%CE%B5%20improves%20obesity-related%20metabolic%20dysfunctions%20in%20mice&author=SM%20Reilly&author=SH%20Chiang&author=SJ%20Decker&author=L%20Chang&author=M%20Uhm&volume=19&publication_year=2013&pages=313-321&pmid=23396211&doi=10.1038/nm.3082&?
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- How much does https://scholar.google.com/scholar_lookup?journal=Diabetes&title=Elevated%20toll-like%20receptor%204%20expression%20and%20signaling%20in%20muscle%20from%20insulin-resistant%20subjects&author=SM%20Reyna&author=S%20Ghosh&author=P%20Tantiwong&author=CS%20Meka&author=P%20Eagan&volume=57&publication_year=2008&pages=2595-2602&pmid=18633101&doi=10.2337/db08-0038& net monthly?
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- What are the total earnings of https://doi.org/10.1038/34178?
- How much does https://scholar.google.com/scholar_lookup?journal=Nature&title=The%20peroxisome%20proliferator-activated%20receptor-gamma%20is%20a%20negative%20regulator%20of%20macrophage%20activation&author=M%20Ricote&author=AC%20Li&author=TM%20Willson&author=CJ%20Kelly&author=CK%20Glass&volume=391&publication_year=1998&pages=79-82&pmid=9422508&doi=10.1038/34178& pull in monthly?
- What's the revenue for https://doi.org/10.1126/science.1241214?
- How profitable is https://scholar.google.com/scholar_lookup?journal=Science&title=Gut%20microbiota%20from%20twins%20discordant%20for%20obesity%20modulate%20metabolism%20in%20mice&author=VK%20Ridaura&author=JJ%20Faith&author=FE%20Rey&author=J%20Cheng&author=AE%20Duncan&volume=341&publication_year=2013&pages=1241214&pmid=24009397&doi=10.1126/science.1241214&?
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- Earnings of https://doi.org/10.1111/j.1463-1326.2012.01637.x
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- See how much https://doi.org/10.1016/j.peptides.2007.03.006 makes per month
- What's the income generated by https://scholar.google.com/scholar_lookup?journal=Peptides&title=TNF-alpha%20acts%20in%20the%20hypothalamus%20inhibiting%20food%20intake%20and%20increasing%20the%20respiratory%20quotient%E2%80%93effects%20on%20leptin%20and%20insulin%20signaling%20pathways&author=T%20Romanatto&author=M%20Cesquini&author=ME%20Amaral&author=EA%20Roman&author=JC%20Moraes&volume=28&publication_year=2007&pages=1050-1058&pmid=17459524&doi=10.1016/j.peptides.2007.03.006& each month?
- What's the financial intake of https://doi.org/10.1016/j.cmet.2009.09.006?
- What's the total monthly financial gain of https://scholar.google.com/scholar_lookup?journal=Cell%20Metab&title=Hematopoietic%20cell-specific%20deletion%20of%20toll-like%20receptor%204%20ameliorates%20hepatic%20and%20adipose%20tissue%20insulin%20resistance%20in%20high-fat-fed%20mice&author=M%20Saberi&author=NB%20Woods&author=C%20de%20Luca&author=S%20Schenk&author=JC%20Lu&volume=10&publication_year=2009&pages=419-429&pmid=19883619&doi=10.1016/j.cmet.2009.09.006&?
- https://doi.org/10.1016/j.cmet.2009.09.007's total income per month
- Earnings of https://scholar.google.com/scholar_lookup?journal=Cell%20Metab&title=Prevention%20of%20steatosis%20by%20hepatic%20JNK1&author=G%20Sabio&author=J%20Cavanagh-Kyros&author=HJ%20Ko&author=DY%20Jung&author=S%20Gray&volume=10&publication_year=2009&pages=491-498&pmid=19945406&doi=10.1016/j.cmet.2009.09.007&
- Earnings of https://doi.org/10.1172/JCI77812
- Find out how much https://scholar.google.com/scholar_lookup?journal=J.%20Clin.%20Invest&title=The%20pathogenesis%20of%20insulin%20resistance:%20integrating%20signaling%20pathways%20and%20substrate%20flux&author=VT%20Samuel&author=GI%20Shulman&volume=126&publication_year=2016&pages=12-22&pmid=26727229&doi=10.1172/JCI77812& earns monthly
- Earnings of https://doi.org/10.1126/science.1219179
- https://scholar.google.com/scholar_lookup?journal=Science&title=A%20lineage%20of%20myeloid%20cells%20independent%20of%20Myb%20and%20hematopoietic%20stem%20cells&author=C%20Schulz&author=E%20Gomez%20Perdiguero&author=L%20Chorro&author=H%20Szabo-Rogers&author=N%20Cagnard&volume=336&publication_year=2012&pages=86-90&pmid=22442384&doi=10.1126/science.1219179&'s total income per month
- Earnings of https://doi.org/10.1002/oby.21248
- How much income is https://scholar.google.com/scholar_lookup?journal=Obesity%20(Silver%20Spring)&title=Radiologic%20evidence%20that%20hypothalamic%20gliosis%20is%20associated%20with%20obesity%20and%20insulin%20resistance%20in%20humans&author=EA%20Schur&author=SJ%20Melhorn&author=SK%20Oh&author=JM%20Lacy&author=KE%20Berkseth&volume=23&publication_year=2015&pages=2142-2148&pmid=26530930&doi=10.1002/oby.21248& earning monthly?
- What's the monthly money flow for https://doi.org/10.1042/BJ20060706?
- How much does https://scholar.google.com/scholar_lookup?journal=Biochem.%20J&title=Carboxyatractyloside%20effects%20on%20brown-fat%20mitochondria%20imply%20that%20the%20adenine%20nucleotide%20translocator%20isoforms%20ANT1%20and%20ANT2%20may%20be%20responsible%20for%20basal%20and%20fatty-acid-induced%20uncoupling%20respectively&author=IG%20Shabalina&author=TV%20Kramarova&author=J%20Nedergaard&author=B%20Cannon&volume=399&publication_year=2006&pages=405-414&pmid=16831128&doi=10.1042/BJ20060706& gross monthly?
- Revenue of https://doi.org/10.1038/oby.2010.174
- What's the profit of https://scholar.google.com/scholar_lookup?journal=Obesity%20(Silver%20Spring)&title=The%20prevalence%20of%20metabolically%20healthy%20obese%20subjects%20defined%20by%20BMI%20and%20dual-energy%20X-ray%20absorptiometry&author=JL%20Shea&author=EW%20Randell&author=G%20Sun&volume=19&publication_year=2011&pages=624-630&pmid=20706202&doi=10.1038/oby.2010.174&?
- How much profit is https://doi.org/10.1172/JCI28898 making per month?
- Explore the financials of https://scholar.google.com/scholar_lookup?journal=J.%20Clin.%20Invest&title=TLR4%20links%20innate%20immunity%20and%20fatty%20acid-induced%20insulin%20resistance&author=H%20Shi&author=MV%20Kokoeva&author=K%20Inouye&author=I%20Tzameli&author=H%20Yin&volume=116&publication_year=2006&pages=3015-3025&pmid=17053832&doi=10.1172/JCI28898&
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- What are the earnings of https://scholar.google.com/scholar_lookup?journal=J.%20Clin.%20Invest&title=Macrophage%20plasticity%20and%20polarization:%20in%20vivo%20veritas&author=A%20Sica&author=A%20Mantovani&volume=122&publication_year=2012&pages=787-795&pmid=22378047&doi=10.1172/JCI59643&?
- How much does https://doi.org/10.2337/dc12-1835 earn?
- Monthly income for https://scholar.google.com/scholar_lookup?journal=Diabetes%20Care&title=Double-blind,%20randomized%20study%20evaluating%20the%20glycemic%20and%20anti-inflammatory%20effects%20of%20subcutaneous%20LY2189102,%20a%20neutralizing%20IL-1%CE%B2%20antibody,%20in%20patients%20with%20type%202%20diabetes&author=J%20Sloan-Lancaster&author=E%20Abu-Raddad&author=J%20Polzer&author=JW%20Miller&author=JC%20Scherer&volume=36&publication_year=2013&pages=2239-2246&pmid=23514733&doi=10.2337/dc12-1835&
- What is the monthly revenue of https://doi.org/10.1111/joim.12540?
- Get to know https://scholar.google.com/scholar_lookup?journal=J.%20Intern.%20Med&title=Adipose%20tissue%20regulates%20insulin%20sensitivity:%20role%20of%20adipogenesis,%20de%20novo%20lipogenesis%20and%20novel%20lipids&author=U%20Smith&author=BB%20Kahn&volume=280&publication_year=2016&pages=465-475&pmid=27699898&doi=10.1111/joim.12540&'s earnings
- How much profit is https://doi.org/10.1073/pnas.0607626103 making per month?
- How much profit does https://scholar.google.com/scholar_lookup?journal=Proc.%20Natl.%20Acad.%20Sci.%20USA&title=Saturated%20fatty%20acids%20inhibit%20induction%20of%20insulin%20gene%20transcription%20by%20JNK-mediated%20phosphorylation%20of%20insulin-receptor%20substrates&author=G%20Solinas&author=W%20Naugler&author=F%20Galimi&author=MS%20Lee&author=M%20Karin&volume=103&publication_year=2006&pages=16454-16459&pmid=17050683&doi=10.1073/pnas.0607626103& generate?
- What's the financial outcome of https://doi.org/10.1152/ajpgi.00185.2007?
- Income figures for https://scholar.google.com/scholar_lookup?journal=Am.%20J.%20Physiol.%20Gastrointest.%20Liver%20Physiol&title=Selective%20inactivation%20of%20NF-kappaB%20in%20the%20liver%20using%20NF-kappaB%20decoy%20suppresses%20CCl4-induced%20liver%20injury%20and%20fibrosis&author=G%20Son&author=Y%20Iimuro&author=E%20Seki&author=T%20Hirano&author=Y%20Kaneda&volume=293&publication_year=2007&pages=G631-G639&pmid=17640975&doi=10.1152/ajpgi.00185.2007&
- How much profit does https://doi.org/10.2337/diacare.29.04.06.dc05-1938 generate?
- Income figures for https://scholar.google.com/scholar_lookup?journal=Diabetes%20Care&title=Alpha2-Heremans-Schmid%20glycoprotein/fetuin-A%20is%20associated%20with%20insulin%20resistance%20and%20fat%20accumulation%20in%20the%20liver%20in%20humans&author=N%20Stefan&author=AM%20Hennige&author=H%20Staiger&author=J%20Machann&author=F%20Schick&volume=29&publication_year=2006&pages=853-857&pmid=16567827&doi=10.2337/diacare.29.04.06.dc05-1938&
- How much revenue does https://doi.org/10.1152/physrev.1998.78.2.393 produce monthly?
- Earnings of https://scholar.google.com/scholar_lookup?journal=Physiol.%20Rev&title=Contributions%20of%20microbes%20in%20vertebrate%20gastrointestinal%20tract%20to%20production%20and%20conservation%20of%20nutrients&author=CE%20Stevens&author=ID%20Hume&volume=78&publication_year=1998&pages=393-427&pmid=9562034&doi=10.1152/physrev.1998.78.2.393&
- Find out how much https://doi.org/10.1371/journal.pone.0135842 earns monthly
- How much does https://scholar.google.com/scholar_lookup?journal=PLoS%20ONE&title=Suppression%20of%20Adaptive%20Immune%20Cell%20Activation%20Does%20Not%20Alter%20Innate%20Immune%20Adipose%20Inflammation%20or%20Insulin%20Resistance%20in%20Obesity&author=M%20Subramanian&author=L%20Ozcan&author=DS%20Ghorpade&author=AW%20Ferrante&author=I%20Tabas&volume=10&publication_year=2015&pages=e0135842&pmid=26317499&doi=10.1371/journal.pone.0135842& pull in monthly?
- What's the financial gain of https://doi.org/10.1371/journal.pone.0013953?
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- How much does https://doi.org/10.1073/pnas.1200447109 earn?
- What's the income of https://scholar.google.com/scholar_lookup?journal=Proc.%20Natl.%20Acad.%20Sci.%20USA&title=Dichotomous%20effects%20of%20VEGF-A%20on%20adipose%20tissue%20dysfunction&author=K%20Sun&author=I%20Wernstedt%20Asterholm&author=CM%20Kusminski&author=AC%20Bueno&author=ZV%20Wang&volume=109&publication_year=2012&pages=5874-5879&pmid=22451920&doi=10.1073/pnas.1200447109&?
- Revenue of https://doi.org/10.1128/MCB.00951-12
- What's the monthly income of https://scholar.google.com/scholar_lookup?journal=Mol.%20Cell.%20Biol&title=Selective%20inhibition%20of%20hypoxia-inducible%20factor%201%CE%B1%20ameliorates%20adipose%20tissue%20dysfunction&author=K%20Sun&author=N%20Halberg&author=M%20Khan&author=UJ%20Magalang&author=PE%20Scherer&volume=33&publication_year=2013&pages=904-917&pmid=23249949&doi=10.1128/MCB.00951-12&?
- What's the total monthly financial gain of https://doi.org/10.1016/j.cmet.2012.12.010?
- How much revenue does https://scholar.google.com/scholar_lookup?journal=Cell%20Metab&title=Adipose%20vascular%20endothelial%20growth%20factor%20regulates%20metabolic%20homeostasis%20through%20angiogenesis&author=HK%20Sung&author=KO%20Doh&author=JE%20Son&author=JG%20Park&author=Y%20Bae&volume=17&publication_year=2013&pages=61-72&pmid=23312284&doi=10.1016/j.cmet.2012.12.010& bring in?
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- How much money does https://doi.org/10.1016/j.cmet.2016.02.001 generate?
- How much cash flow does https://scholar.google.com/scholar_lookup?journal=Cell%20Metab&title=A%20Long-Acting%20FGF21%20Molecule,%20PF-05231023,%20Decreases%20Body%20Weight%20and%20Improves%20Lipid%20Profile%20in%20Non-human%20Primates%20and%20Type%202%20Diabetic%20Subjects&author=S%20Talukdar&author=Y%20Zhou&author=D%20Li&author=M%20Rossulek&author=J%20Dong&volume=23&publication_year=2016&pages=427-440&pmid=26959184&doi=10.1016/j.cmet.2016.02.001& have monthly?
- Revenue of https://doi.org/10.1016/j.smim.2011.11.009
- https://scholar.google.com/scholar_lookup?journal=Semin.%20Immunol&title=Induction%20of%20Treg%20cells%20in%20the%20mouse%20colonic%20mucosa:%20a%20central%20mechanism%20to%20maintain%20host-microbiota%20homeostasis&author=T%20Tanoue&author=K%20Honda&volume=24&publication_year=2012&pages=50-57&pmid=22172550&doi=10.1016/j.smim.2011.11.009&'s financial summary
- Revenue of https://doi.org/10.1210/en.2017-00024
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- Earnings of https://doi.org/10.1172/JCI59660
- What's the income generated by https://scholar.google.com/scholar_lookup?journal=J.%20Clin.%20Invest&title=Obesity%20is%20associated%20with%20hypothalamic%20injury%20in%20rodents%20and%20humans&author=JP%20Thaler&author=CX%20Yi&author=EA%20Schur&author=SJ%20Guyenet&author=BH%20Hwang&volume=122&publication_year=2012&pages=153-162&pmid=22201683&doi=10.1172/JCI59660& each month?
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