
NCBI . NLM . NIH . GOV {
}
Title[redir]:
The Natural Cytotoxicity Receptors in Health and Disease - PMC
Description:
The Natural Cytotoxicity Receptors (NCRs), NKp46, NKp44, and NKp30, were some of the first human activating Natural Killer (NK) cell receptors involved in the non-MHC-restricted recognition of tumor cells to be cloned over 20 years ago. Since this ...
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Keywords {🔍}
cells, nkp, pubmed, google, scholar, doi, cell, pmc, article, free, tumor, natural, ncr, ligands, human, expression, receptor, ncrs, immunol, expressed, killer, protein, cytotoxicity, activation, receptors, ligand, blood, shown, signaling, activating, cancer, disease, infection, recognition, bind, mice, type, immune, ilc, virus, soluble, function, patients, binding, surface, domain, innate, growth, jimmunol, proteins,
Topics {✒️}
tnf-related apoptosis-inducing ligand il-15-responsive ifn-γ-producing cells cell-types express t-bet ncr-based cancer immunotherapies tyrosine-based activation motif b7-h6-specific bite promoted genome-wide association study induce caspase-8-mediated apoptosis nk-activating receptor nkp46/ncr1 cd3−cd56+ ilc population nk cell-mediated deletion interleukin-15-dependent t-cell rewiring t-cell responses v-shaped conformation positioned c5-convertase enzyme complexes susan keyes-pearce microbiology platelet-derived growth factor nk cell-fungal conjugates human natural-killer cells post-translational protein targeting plasmodium falciparum-parasitized erythrocytes inhibiting nkp30-mediated cytotoxicity sialic acid-dependent manner double-stranded rna virus platelet-derived growth factors multiple anti-tumor specificities tissue-resident natural killer reovirus-based tumor therapy reovirus-based cancer therapy human leukocyte antigen-b nkp30 receptor-dependent cytotoxicity nk cell-activating receptors interferon-alpha-induced trail corticosteroid-induced adrenal suppression nk92 nk cell-line β-cell insulin granules pmc beta search tgf-β-responsive car nk cell-mediated clearance promote anti-tumor responses pd-l1/pd1-l2 breast tumor cell-lines b7-h6 expressing tumors lyse trail-sensitive tumors b7-h6-specific car heparan sulfate/heparin sequences b7-h6 contacts nkp30 mixed-lineage leukemia protein-5 cancer ncr-mediated control immunosuppressive ilc2-mdsc axis
Questions {❓}
- Thus, many open questions regarding NCR ligand binding still remain, such as how can a given NCR bind to such a broad range of structurally diverse ligands?
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- What's the total monthly financial gain of https://scholar.google.com/scholar_lookup?journal=Immunity.&title=Cytomegalovirus%20infection%20drives%20adaptive%20epigenetic%20diversification%20of%20NK%20cells%20with%20altered%20signaling%20and%20effector%20function&author=H%20Schlums&author=F%20Cichocki&author=B%20Tesi&author=J%20Theorell&author=V%20Beziat&volume=42&publication_year=2015&pages=443-56&pmid=25786176&doi=10.1016/j.immuni.2015.02.008&?
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- https://doi.org/10.1073/pnas.1720564115 income
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- Revenue of https://scholar.google.com/scholar_lookup?journal=Front%20Immunol.&title=Regulation%20of%20the%20functions%20of%20natural%20cytotoxicity%20receptors%20by%20interactions%20with%20diverse%20ligands%20and%20alterations%20in%20splice%20variant%20expression&author=T%20Pazina&author=A%20Shemesh&author=M%20Brusilovsky&author=A%20Porgador&author=KS%20Campbell&volume=8&publication_year=2017&pages=369&pmid=28424697&doi=10.3389/fimmu.2017.00369&
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- How much does https://scholar.google.com/scholar_lookup?journal=Oncotarget.&title=Survival%20in%20acute%20myeloid%20leukemia%20is%20associated%20with%20NKp44%20splice%20variants&author=A%20Shemesh&author=M%20Brusilovsky&author=U%20Hadad&author=O%20Teltsh&author=A%20Edri&volume=7&publication_year=2016&pages=32933-45&pmid=27102296&doi=10.18632/oncotarget.8782& generate monthly?
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- https://scholar.google.com/scholar_lookup?journal=Immunity.&title=ROR%CE%B3t+%20innate%20lymphoid%20cells%20acquire%20a%20proinflammatory%20program%20upon%20engagement%20of%20the%20activating%20receptor%20NKp44&author=T%20Glatzer&author=M%20Killig&author=J%20Meisig&author=I%20Ommert&author=M%20Luetke-Eversloh&volume=38&publication_year=2013&pages=1223-35&pmid=23791642&doi=10.1016/j.immuni.2013.05.013&'s total income per month
- Check the income stats for https://doi.org/10.1016/j.ajhg.2016.11.007
- How much profit does https://scholar.google.com/scholar_lookup?journal=Am%20J%20Hum%20Genet.&title=Genome-wide%20association%20study%20identifies%2027%20Loci%20influencing%20concentrations%20of%20circulating%20cytokines%20and%20growth%20factors&author=AV%20Ahola-Olli&author=P%20W%C3%BCrtz&author=AS%20Havulinna&author=K%20Aalto&author=N%20Pitk%C3%A4nen&volume=100&publication_year=2017&pages=40-50&pmid=27989323&doi=10.1016/j.ajhg.2016.11.007& make?
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- Monthly income for https://doi.org/10.1093/jjco/hyu187
- How much does https://scholar.google.com/scholar_lookup?journal=Jpn%20J%20Clin%20Oncol.&title=Nidogen-1:%20a%20candidate%20biomarker%20for%20ovarian%20serous%20cancer&author=L%20Li&author=Y%20Zhang&author=N%20Li&author=L%20Feng&author=H%20Yao&volume=45&publication_year=2015&pages=176-82&pmid=25378651&doi=10.1093/jjco/hyu187& generate monthly?
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- How much does https://scholar.google.com/scholar_lookup?journal=Neoplasia.&title=Nidogen-1%20degraded%20by%20Cathepsin%20S%20can%20be%20quantified%20in%20serum%20and%20is%20associated%20with%20non-small%20cell%20lung%20cancer&author=N%20Willumsen&author=CL%20Bager&author=DJ%20Leeming&author=A-C%20Bay-Jensen&author=MA%20Karsdal&volume=19&publication_year=2017&pages=271-8&pmid=28282545&doi=10.1016/j.neo.2017.01.008& net monthly?
- What's the income generated by https://doi.org/10.1080/2162402X.2018.1434467 each month?
- Explore the financials of https://scholar.google.com/scholar_lookup?journal=Oncoimmunology.&title=The%20role%20of%20Galectin-3%20in%20modulating%20tumor%20growth%20and%20immunosuppression%20within%20the%20tumor%20microenvironment&author=M%20Farhad&author=AS%20Rolig&author=WL%20Redmond&volume=7&publication_year=2018&pages=e1434467&pmid=29872573&doi=10.1080/2162402X.2018.1434467&
- How much revenue does https://doi.org/10.1038/nri3365 generate?
- https://scholar.google.com/scholar_lookup?journal=Nat%20Rev%20Immunol.&title=Innate%20lymphoid%20cells%E2%80%93a%20proposal%20for%20uniform%20nomenclature&author=H%20Spits&author=D%20Artis&author=M%20Colonna&author=A%20Diefenbach&author=JP%20Di%20Santo&volume=13&publication_year=2013&pages=145-9&pmid=23348417&doi=10.1038/nri3365&'s financial summary
- What's the income of https://doi.org/10.1016/j.coi.2018.11.004?
- How much does https://scholar.google.com/scholar_lookup?journal=Curr%20Opin%20Immunol.&title=Innate%20lymphoid%20cell%20sensing%20of%20tissue%20vitality&author=AD%20Barrow&author=M%20Colonna&volume=56&publication_year=2018&pages=82-93&pmid=30529190&doi=10.1016/j.coi.2018.11.004& earn?
- How much money does https://doi.org/10.1016/j.immuni.2016.03.007 generate?
- What's the total monthly financial gain of https://scholar.google.com/scholar_lookup?journal=Immunity.&title=Transforming%20growth%20factor-%CE%B2%20signaling%20guides%20the%20differentiation%20of%20innate%20lymphoid%20cells%20in%20salivary%20glands&author=VS%20Cortez&author=L%20Cervantes-Barragan&author=ML%20Robinette&author=JK%20Bando&author=Y%20Wang&volume=44&publication_year=2016&pages=1127-39&pmid=27156386&doi=10.1016/j.immuni.2016.03.007&?
- What's the income of https://doi.org/10.1084/jem.193.6.661?
- What is the monthly revenue of https://scholar.google.com/scholar_lookup?journal=J%20Exp%20Med.&title=Tumor%20necrosis%20factor%E2%80%93related%20apoptosis-inducing%20ligand%20(Trail)%20contributes%20to%20interferon%20%CE%B3-dependent%20natural%20killer%20cell%20protection%20from%20tumor%20metastasis&author=MJ%20Smyth&author=E%20Cretney&author=K%20Takeda&author=RH%20Wiltrout&author=LM%20Sedger&volume=193&publication_year=2001&pages=661-70&pmid=11257133&doi=10.1084/jem.193.6.661&?
- How much does https://doi.org/10.1053/j.gastro.2010.01.051 make?
- Profit of https://scholar.google.com/scholar_lookup?journal=Gastroenterology.&title=Interferon-alpha-induced%20TRAIL%20on%20natural%20killer%20cells%20is%20associated%20with%20control%20of%20hepatitis%20C%20virus%20infection&author=KA%20Stegmann&author=NK%20Bj%C3%B6rkstr%C3%B6m&author=H%20Veber&author=S%20Ciesek&author=P%20Riese&volume=138&publication_year=2010&pages=1885-97&pmid=20334827&doi=10.1053/j.gastro.2010.01.051&
- Find out how much https://scholar.google.com/scholar_lookup?journal=J%20Immunol.&title=Expression%20and%20function%20of%20TNF-related%20apoptosis-inducing%20ligand%20on%20murine%20activated%20NK%20cells&author=N%20Kayagaki&author=N%20Yamaguchi&author=M%20Nakayama&author=K%20Takeda&author=H%20Akiba&volume=163&publication_year=1999&pages=1906-13&pmid=10438925& earns monthly
- How much profit does https://doi.org/10.1006/cimm.2001.1896 generate?
- How much does https://scholar.google.com/scholar_lookup?journal=Cell%20Immunol.&title=Involvement%20of%20tumor%20necrosis%20factor-related%20apoptosis-inducing%20ligand%20in%20NK%20cell-mediated%20and%20IFN-gamma-dependent%20suppression%20of%20subcutaneous%20tumor%20growth&author=K%20Takeda&author=MJ%20Smyth&author=E%20Cretney&author=Y%20Hayakawa&author=N%20Yamaguchi&volume=214&publication_year=2001&pages=194-200&pmid=12088418&doi=10.1006/cimm.2001.1896& rake in every month?
- What are the earnings of https://doi.org/10.4049/jimmunol.168.3.1356?
- How much does https://scholar.google.com/scholar_lookup?journal=J%20Immunol.&title=Increased%20susceptibility%20to%20tumor%20initiation%20and%20metastasis%20in%20TNF-related%20apoptosis-inducing%20ligand-deficient%20mice&author=E%20Cretney&author=K%20Takeda&author=H%20Yagita&author=M%20Glaccum&author=JJ%20Peschon&volume=168&publication_year=2002&pages=1356-61&pmid=11801676&doi=10.4049/jimmunol.168.3.1356& rake in every month?
- What's https://scholar.google.com/scholar_lookup?journal=Cancer%20Res.&title=Tumor%20necrosis%20factor-related%20apoptosis-inducing%20ligand-mediated%20apoptosis%20is%20an%20important%20endogenous%20mechanism%20for%20resistance%20to%20liver%20metastases%20in%20murine%20renal%20cancer&author=N%20Seki&author=Y%20Hayakawa&author=AD%20Brooks&author=J%20Wine&author=RH%20Wiltrout&volume=63&publication_year=2003&pages=207-13&pmid=12517799&'s gross income?
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- What are the earnings of https://scholar.google.com/scholar_lookup?journal=J%20Immunol.&title=Cutting%20edge:%20TRAIL%20deficiency%20accelerates%20hematological%20malignancies&author=N%20Zerafa&author=JA%20Westwood&author=E%20Cretney&author=S%20Mitchell&author=P%20Waring&volume=175&publication_year=2005&pages=5586-90&pmid=16237043&doi=10.4049/jimmunol.175.9.5586&?
- Monthly income for https://doi.org/10.1016/j.celrep.2018.03.023
- How much profit does https://scholar.google.com/scholar_lookup?journal=Cell%20Rep.&title=The%20murine%20natural%20cytotoxic%20receptor%20NKp46/NCR1%20controls%20TRAIL%20protein%20expression%20in%20NK%20cells%20and%20ILC1s&author=S%20Sheppard&author=IS%20Schuster&author=CE%20Andoniou&author=C%20Cocita&author=T%20Adejumo&volume=22&publication_year=2018&pages=3385-92&pmid=29590608&doi=10.1016/j.celrep.2018.03.023& generate?
- Revenue of https://doi.org/10.4049/jimmunol.1701333
- How much does https://scholar.google.com/scholar_lookup?journal=J%20Immunol.&title=NKp46%20calibrates%20tumoricidal%20potential%20of%20type%201%20innate%20lymphocytes%20by%20regulating%20TRAIL%20expression&author=G%20Turchinovich&author=S%20Ganter&author=A%20B%C3%A4renwaldt&author=D%20Finke&volume=200&publication_year=2018&pages=3762-8&pmid=29661825&doi=10.4049/jimmunol.1701333& make?
- Get to know https://doi.org/10.1016/j.immuni.2014.09.013's earnings
- How much does https://scholar.google.com/scholar_lookup?journal=Immunity.&title=TRAIL+%20NK%20cells%20control%20CD4+%20T%20cell%20responses%20during%20chronic%20viral%20infection%20to%20limit%20autoimmunity&author=IS%20Schuster&author=ME%20Wikstrom&author=G%20Brizard&author=JD%20Coudert&author=MJ%20Estcourt&volume=41&publication_year=2014&pages=646-56&pmid=25367576&doi=10.1016/j.immuni.2014.09.013& gross monthly?
- Profit of https://doi.org/10.1084/jem.20061287
- Monthly income for https://scholar.google.com/scholar_lookup?journal=J%20Exp%20Med.&title=Cytokines%20induced%20during%20chronic%20hepatitis%20B%20virus%20infection%20promote%20a%20pathway%20for%20NK%20cell-mediated%20liver%20damage&author=C%20Dunn&author=M%20Brunetto&author=G%20Reynolds&author=T%20Christophides&author=PT%20Kennedy&volume=204&publication_year=2007&pages=667-80&pmid=17353365&doi=10.1084/jem.20061287&
- Financial intake of https://doi.org/10.1084/jem.20121172
- Financial intake of https://scholar.google.com/scholar_lookup?journal=J%20Exp%20Med.&title=Up-regulation%20of%20a%20death%20receptor%20renders%20antiviral%20T%20cells%20susceptible%20to%20NK%20cell-mediated%20deletion&author=D%20Peppa&author=US%20Gill&author=G%20Reynolds&author=NJW%20Easom&author=LJ%20Pallett&volume=210&publication_year=2013&pages=99-114&pmid=23254287&doi=10.1084/jem.20121172&
- Revenue of https://doi.org/10.1158/1078-0432.CCR-16-0597
- How much profit does https://scholar.google.com/scholar_lookup?journal=Clin%20Cancer%20Res.&title=Delta%20one%20T%20cells%20for%20immunotherapy%20of%20chronic%20lymphocytic%20leukemia:%20clinical-grade%20expansion/differentiation%20and%20preclinical%20proof%20of%20concept&author=AR%20Almeida&author=DV%20Correia&author=A%20Fernandes-Platzgummer&author=CL%20da%20Silva&author=MG%20da%20Silva&volume=22&publication_year=2016&pages=5795-804&pmid=27307596&doi=10.1158/1078-0432.CCR-16-0597& make?
- What's https://doi.org/10.1038/nm.4278's gross income?
- How much income does https://scholar.google.com/scholar_lookup?journal=Nat%20Med.&title=A%20distinct%20innate%20lymphoid%20cell%20population%20regulates%20tumor-associated%20T%20cells&author=SQ%20Crome&author=LT%20Nguyen&author=S%20Lopez-Verges&author=SYC%20Yang&author=B%20Martin&volume=23&publication_year=2017&pages=368-75&pmid=28165478&doi=10.1038/nm.4278& have?
- What's the financial intake of https://doi.org/10.1038/nature08900?
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- Financial intake of https://doi.org/10.1038/ni.3489
- How much does https://scholar.google.com/scholar_lookup?journal=Nat%20Immunol.&title=Innate%20lymphoid%20cells%20as%20regulators%20of%20immunity,%20inflammation%20and%20tissue%20homeostasis&author=CSN%20Klose&author=D%20Artis&volume=17&publication_year=2016&pages=765-74&pmid=27328006&doi=10.1038/ni.3489& pull in?
- How much revenue does https://doi.org/10.1016/j.jaci.2013.10.056 generate?
- How much revenue does https://scholar.google.com/scholar_lookup?journal=J%20Allergy%20Clin%20Immunol.&title=Prostaglandin%20D2%20activates%20group%202%20innate%20lymphoid%20cells%20through%20chemoattractant%20receptor-homologous%20molecule%20expressed%20on%20TH2%20cells&author=L%20Xue&author=M%20Salimi&author=I%20Panse&author=JM%20Mj%C3%B6sberg&author=ANJ%20McKenzie&volume=133&publication_year=2014&pages=1184-94&pmid=24388011&doi=10.1016/j.jaci.2013.10.056& bring in?
- How much does https://doi.org/10.1038/s41467-017-00678-2 rake in every month?
- What are the total earnings of https://scholar.google.com/scholar_lookup?journal=Nat%20Commun.&title=Tumour-derived%20PGD2%20and%20NKp30-B7H6%20engagement%20drives%20an%20immunosuppressive%20ILC2-MDSC%20axis&author=S%20Trabanelli&author=MF%20Chevalier&author=A%20Martinez-Usatorre&author=A%20Gomez-Cadena&author=B%20Salom%C3%A9&volume=8&publication_year=2017&pages=593&pmid=28928446&doi=10.1038/s41467-017-00678-2&?
- Revenue of https://doi.org/10.1002/eji.201646756
- What is the earnings of https://scholar.google.com/scholar_lookup?journal=Eur%20J%20Immunol.&title=NK-cell%20receptors%20NKp46%20and%20NCR1%20control%20human%20metapneumovirus%20infection&author=M%20Diab&author=A%20Glasner&author=B%20Isaacson&author=Y%20Bar-On&author=Y%20Drori&volume=47&publication_year=2017&pages=692-703&pmid=28191644&doi=10.1002/eji.201646756&?
- How much profit does https://doi.org/10.1002/eji.201646763 generate?
- What's the total monthly financial gain of https://scholar.google.com/scholar_lookup?journal=Eur%20J%20Immunol.&title=NCR1-deficiency%20diminishes%20the%20generation%20of%20protective%20murine%20cytomegalovirus%20antibodies%20by%20limiting%20follicular%20helper%20T-cell%20maturation&author=A%20Miletic&author=M%20Lenartic&author=B%20Popovic&author=I%20Brizic&author=T%20Trsan&volume=47&publication_year=2017&pages=1443-56&pmid=28643847&doi=10.1002/eji.201646763&?
- How much money does https://doi.org/10.1038/s41598-017-08866-2 generate?
- What is the earnings of https://scholar.google.com/scholar_lookup?journal=Sci%20Rep.&title=Human%20cytomegalovirus%20escapes%20immune%20recognition%20by%20NK%20cells%20through%20the%20downregulation%20of%20B7-H6%20by%20the%20viral%20genes%20US18%20and%20US20&author=Y%20Charpak-Amikam&author=T%20Kubsch&author=E%20Seidel&author=E%20Oiknine-Djian&author=N%20Cavaletto&volume=7&publication_year=2017&pages=8661&pmid=28819195&doi=10.1038/s41598-017-08866-2&?
- How much does https://doi.org/10.1128/JVI.01164-16 net monthly?
- How much does https://scholar.google.com/scholar_lookup?journal=J%20Virol.&title=Human%20Herpesvirus%206B%20downregulates%20expression%20of%20activating%20ligands%20during%20lytic%20infection%20to%20escape%20elimination%20by%20natural%20killer%20cells&author=D%20Schmiedel&author=J%20Tai&author=F%20Levi-Schaffer&author=S%20Dovrat&author=O%20Mandelboim&volume=90&publication_year=2016&pages=9608-17&pmid=27535049&doi=10.1128/JVI.01164-16& net monthly?
- What is the earnings of https://doi.org/10.1371/journal.pone.0178746?
- How much does https://scholar.google.com/scholar_lookup?journal=PLoS%20ONE.&title=The%20hemagglutinin-neuramidinase%20protein%20of%20Newcastle%20disease%20virus%20upregulates%20expression%20of%20the%20TRAIL%20gene%20in%20murine%20natural%20killer%20cells%20through%20the%20activation%20of%20Syk%20and%20NF-%CE%BAB&author=Y%20Liang&author=D-Z%20Song&author=S%20Liang&author=Z-F%20Zhang&author=L-X%20Gao&volume=12&publication_year=2017&pages=e0178746&pmid=28614370&doi=10.1371/journal.pone.0178746& pull in?
- https://doi.org/10.1038/ni1322's financial summary
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