
NCBI . NLM . NIH . GOV {
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Title[redir]:
Integrin Receptors on Tumor Cells Facilitate NK cell-mediated Antibody-dependent Cytotoxicity - PMC
Description:
NK cells that mediate ADCC play an important role in tumor-specific immunity. We have examined factors limiting specific lysis of tumor cells by CD16.NK-92 cells induced by CNTO 95LF antibodies recognizing αV integrins that are overexpressed on many ...
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Keywords {🔍}
cells, cnto, doi, antibodies, tumor, antibody, fig, cell, pubmed, google, scholar, adcc, skbr, integrins, cancer, cdnk, human, specific, lysis, igg, killing, icam, pmc, target, herceptin, binding, data, free, alaala, induced, presence, article, activity, integrin, cytolytic, affinity, effect, surface, receptor, open, cytotoxicity, level, ifnγ, concentrations, curve, expression, high, immunol, receptors, role,
Topics {✒️}
cd11b/src/beta-catenin pathway distinct interferon-gamma-responsive element antibody-dependent cellular cytotoxicity anti-alphav-integrin mab fc n-glycan profiling tailed student t-test pmc beta search ifn-γ-treated skbr3 cells n-linked glycan structures bell-shaped concentration dependence complement-dependent cytotoxicity nk-target cell conjugates cnto 95ala-ala antibody ifn-γ treatment resulted interleukin-2-stimulated nk activity cnto 95ala-ala increased antigen-independent ring junction typical s-shape curve recognizes her2/neu receptor beckman-coulter flow cytometer nk cell-mediated adcc supplementary materials included cell-bound cnto 95lf soluble his6-tagged cd16 bell-shape killing curve cnto 95ala-ala antibodies nk-92-mediated specific lysis 51cr-labeled target cells s-shape killing curve observed dose-limiting effect humanized monoclonal antibody 51cr-labeled tumor cells tumor-specific antibodies directing dose-dependent manner nk-92-mediated cytotoxicity integrin-dependent organization cnto 95lf-induced killing cd18 integrin-activating antibody low-affinity fcgamma receptors enhanced effector function herceptin-mediated cytotoxicity cnto 95lf-induced destruction free normal igg cell free system tumor cells facilitate receptor-ligand interactions occurring unique carbohydrate-carbohydrate interactions induce efficient adcc nk cells facilitate antibody-mediated blockade
Questions {❓}
- Innate or adaptive immunity?
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