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DOI . ORG {}

Detected CMS Systems:

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
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  14. Hosting Providers
  15. CDN Services

We began analyzing https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-019-0971-9, but it redirected us to https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-019-0971-9. The analysis below is for the second page.

Title[redir]:
Exploiting vulnerabilities of cancer by targeting nuclear receptors of stromal cells in tumor microenvironment | Molecular Cancer | Full Text
Description:
The tumor microenvironment is a complex and dynamic cellular community comprising the tumor epithelium and various tumor-supporting cells such as immune cells, fibroblasts, immunosuppressive cells, adipose cells, endothelial cells, and pericytes. The interplay between the tumor microenvironment and tumor cells represents a key contributor to immune evasiveness, physiological hardiness and the local and systemic invasiveness of malignant cells. Nuclear receptors are master regulators of physiological processes and are known to play pro−/anti-oncogenic activities in tumor cells. However, the actions of nuclear receptors in tumor-supporting cells have not been widely studied. Given the excellent druggability and extensive regulatory effects of nuclear receptors, understanding their biological functionality in the tumor microenvironment is of utmost importance. Therefore, the present review aims to summarize recent evidence about the roles of nuclear receptors in tumor-supporting cells and their implications for malignant processes such as tumor proliferation, evasion of immune surveillance, angiogenesis, chemotherapeutic resistance, and metastasis. Based on findings derived mostly from cell culture studies and a few in vivo animal cancer models, the functions of VDR, PPARs, AR, ER and GR in tumor-supporting cells are relatively well-characterized. Evidence for other receptors, such as RARβ, RORγ, and FXR, is limited yet promising. Hence, the nuclear receptor signature in the tumor microenvironment may harbor prognostic value. The clinical prospects of a tumor microenvironment-oriented cancer therapy exploiting the nuclear receptors in different tumor-supporting cells are also encouraging. The major challenge, however, lies in the ability to develop a highly specific drug delivery system to facilitate precision medicine in cancer therapy.

Matching Content Categories {📚}

  • Science
  • Education
  • Health & Fitness

Content Management System {📝}

What CMS is doi.org built with?


Doi.org is built with PLONE.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🏙️ Massive Traffic: 50M - 100M visitors per month


Based on our best estimate, this website will receive around 91,155,781 visitors per month in the current month.

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How Does Doi.org Make Money? {💸}

We can't figure out the monetization strategy.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Doi.org might be earning cash quietly, but we haven't detected the monetization method.

Keywords {🔍}

pubmed, cancer, cells, article, google, scholar, cas, tumor, receptor, cell, cafs, central, nrs, prostate, expression, tme, stromal, endothelial, receptors, activation, fibroblasts, breast, pparγ, growth, nuclear, effects, vdr, therapy, cancerassociated, roles, estrogen, microenvironment, clinical, proliferation, androgen, signaling, treatment, macrophages, angiogenesis, human, development, res, studies, research, steroid, erα, mol, factors, tumors, tumorsupporting,

Topics {✒️}

gov/newsevents/newsroom/pressannouncements/ucm616518 th1/th2/th17/treg cells /tgf-β1/smad/mmp9 signals tumor-targeted anti-angiogenic nanomedicine peroxisome proliferator-activated receptor peroxisome proliferator-activated receptors impairs cell-cell contact urokinase-type plasminogen activator gw4064-mediated anti-tumor effects multi-center clinical trial myeloid-derived suppressor cells pparβ/δ knockout mice pre-existing therapeutic approaches nr-based stroma-directed therapy ideal anti-androgenic agent pan-tumor genomic biomarkers myeloid-derived suppressive cells cell-specific drug delivery serine/threonine kinase receptor epithelial-mesenchymal transition tumor necrosis factor-α b16 melanoma-bearing mice rar-related orphan receptor play pro−/anti-oncogenic activities exhibit evident tumor-supporting nuclear receptor-directed initiation escalating cell-based methodology matrigel-derived endothelial cells wild-type/untreated cafs [15] fenofibrate-induced pparα activation hong sheng cheng caf-induced cisplatin resistance stroma-directed anticancer therapy pan-cancer analyses pparγ ligand 15d-pgj2 pro-invasive paracrine signals tumor-derived endothelial cells dna-bound transcription factors late-stage cervical cancer caf-oriented cancer therapy anti-inflammatory phenotype marked exosomal mir-10a-5p odegaard ji rodent mammary gland improves insulin resistance estrogen receptor-negative phenotype confer pro-tumor effects invasion-promoting breast carcinoma counteracts tumor-promoting activities restricting tumor-infiltrating neutrophils

Questions {❓}

  • Expression and function of androgen receptor in human breast cancer-associated fibroblasts: may androgens shape breast tumor microenvironment?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Exploiting vulnerabilities of cancer by targeting nuclear receptors of stromal cells in tumor microenvironment
         description:The tumor microenvironment is a complex and dynamic cellular community comprising the tumor epithelium and various tumor-supporting cells such as immune cells, fibroblasts, immunosuppressive cells, adipose cells, endothelial cells, and pericytes. The interplay between the tumor microenvironment and tumor cells represents a key contributor to immune evasiveness, physiological hardiness and the local and systemic invasiveness of malignant cells. Nuclear receptors are master regulators of physiological processes and are known to play pro−/anti-oncogenic activities in tumor cells. However, the actions of nuclear receptors in tumor-supporting cells have not been widely studied. Given the excellent druggability and extensive regulatory effects of nuclear receptors, understanding their biological functionality in the tumor microenvironment is of utmost importance. Therefore, the present review aims to summarize recent evidence about the roles of nuclear receptors in tumor-supporting cells and their implications for malignant processes such as tumor proliferation, evasion of immune surveillance, angiogenesis, chemotherapeutic resistance, and metastasis. Based on findings derived mostly from cell culture studies and a few in vivo animal cancer models, the functions of VDR, PPARs, AR, ER and GR in tumor-supporting cells are relatively well-characterized. Evidence for other receptors, such as RARβ, RORγ, and FXR, is limited yet promising. Hence, the nuclear receptor signature in the tumor microenvironment may harbor prognostic value. The clinical prospects of a tumor microenvironment-oriented cancer therapy exploiting the nuclear receptors in different tumor-supporting cells are also encouraging. The major challenge, however, lies in the ability to develop a highly specific drug delivery system to facilitate precision medicine in cancer therapy.
         datePublished:2019-03-30T00:00:00Z
         dateModified:2019-03-30T00:00:00Z
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            Cancer Research
            Oncology
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ScholarlyArticle:
      headline:Exploiting vulnerabilities of cancer by targeting nuclear receptors of stromal cells in tumor microenvironment
      description:The tumor microenvironment is a complex and dynamic cellular community comprising the tumor epithelium and various tumor-supporting cells such as immune cells, fibroblasts, immunosuppressive cells, adipose cells, endothelial cells, and pericytes. The interplay between the tumor microenvironment and tumor cells represents a key contributor to immune evasiveness, physiological hardiness and the local and systemic invasiveness of malignant cells. Nuclear receptors are master regulators of physiological processes and are known to play pro−/anti-oncogenic activities in tumor cells. However, the actions of nuclear receptors in tumor-supporting cells have not been widely studied. Given the excellent druggability and extensive regulatory effects of nuclear receptors, understanding their biological functionality in the tumor microenvironment is of utmost importance. Therefore, the present review aims to summarize recent evidence about the roles of nuclear receptors in tumor-supporting cells and their implications for malignant processes such as tumor proliferation, evasion of immune surveillance, angiogenesis, chemotherapeutic resistance, and metastasis. Based on findings derived mostly from cell culture studies and a few in vivo animal cancer models, the functions of VDR, PPARs, AR, ER and GR in tumor-supporting cells are relatively well-characterized. Evidence for other receptors, such as RARβ, RORγ, and FXR, is limited yet promising. Hence, the nuclear receptor signature in the tumor microenvironment may harbor prognostic value. The clinical prospects of a tumor microenvironment-oriented cancer therapy exploiting the nuclear receptors in different tumor-supporting cells are also encouraging. The major challenge, however, lies in the ability to develop a highly specific drug delivery system to facilitate precision medicine in cancer therapy.
      datePublished:2019-03-30T00:00:00Z
      dateModified:2019-03-30T00:00:00Z
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         Nuclear receptors
         Tumor microenvironment
         Cancer-associated fibroblast
         Myeloid-derived suppressor cells
         Tumor-associated macrophage
         Cancer Research
         Oncology
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         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12943-019-0971-9/MediaObjects/12943_2019_971_Fig2_HTML.png
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               type:PostalAddress
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               type:PostalAddress
            type:Organization
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               type:PostalAddress
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      email:[email protected]
PostalAddress:
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      name:Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore
      name:INRA ToxAlim, UMR1331, Toulouse Cedex 3, France
      name:Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
      name:School of Biological Sciences, Nanyang Technological University Singapore, Singapore, Singapore
      name:Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore

Social Networks {👍}(2)

External Links {🔗}(829)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Prism.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {📦}

  • Crossref

5.25s.