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🌠 Phenomenal Traffic: 5M - 10M visitors per month


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Keywords {🔍}

transcription, doi, pubmed, google, scholar, transcriptional, promoter, chromatin, complexes, cell, factors, histone, recruitment, receptor, gene, promoters, biol, pmc, nuclear, chip, proteins, mol, estrogen, erα, regulation, model, expression, article, frap, nucleosome, dynamic, free, nrs, binding, events, specific, cycle, productive, complex, mobility, receptors, structure, dynamics, dna, remodelling, transcriptionally, cycles, cycling, rna, activation,

Topics {✒️}

er-α-mediated gene expression reversible post-translational modifications er-α-mediated transcriptional cycles pmc beta search atp-dependent remodelling complex atp-dependent remodelling complexes detecting oestrogen receptor-α ikkα-dependent transcription complex tamoxifen-complexed estrogen receptor er-α-mediated transcription multi-subunit protein complexes single live-cell imaging estrogen receptor-regulated transcription distinct chromatin-modifying complexes thyroid hormone-responsive promoters live-cell imaging techniques transcription dynamics evaluated nr-mediated transcriptional activation hormone-induced histone hyperacetylation live-cell imaging experiments real-time cellular dynamics nr-mediated cyclical transcription trap–drip–mediator complexes post-translational modifications nuclear receptor-directed initiation e2-dependent gene sequences agonist-bound nuclear receptors detailed chip-based analysis proteasome-mediated turnover van driel robinson-rechavi p300 regulates transactivation publisher site pdf estrogen receptor α high-mobility-group proteins nuclear hormone receptor achieving transcription requires nr-binding site er-α degradation dynamic protein–chromatin interactions glucocorticoid receptor mobility live-cell imaging estrogen receptor structure oestrogen receptor-α estrogen receptor activity transcription takes place nuclear receptor superfamily mckenna & o'malley energy-dependent processes receptor-interacting protein 140

Questions {❓}

• A model for NR-mediated transcriptional activation?
• Gill G (2004) SUMO and ubiquitin in the nucleus: different functions, similar mechanisms?
• How general is the phenomenon of promoter cycling?
• How is transcriptional cycling initiated?
• If spontaneous dissociation of nucleosomes is vital to initiate the system, this also questions the mechanisms of DNA-binding specificity and sequence recognition: are highly mobile NRs continuously scanning the entire genome for adequate binding sequences?

Social Networks {👍}(6)

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• https://www.linkedin.com/company/ncbinlm
• https://twitter.com/nlm_nih
• https://www.facebook.com/nationallibraryofmedicine
• https://www.youtube.com/user/NLMNIH

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